Vitamin D as a protective factor in multiple sclerosis

Salzer, Jonatan; Hallmans, Göran; Nyström, Maria; Stenlund, Hans; Wadell, Göran; Sundström, Peter

doi:10.1212/wnl.0b013e3182752ea8

Cited by 208 publications

(191 citation statements)

References 29 publications

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“…A longitudinal study evaluated serum vitamin D levels derived from blood samples of seven million US military personnel [85]. Those with 25(OH)D levels superior to 40 ng/mL had a 62% lower chance of developing MS. A more recent prospective study confirmed these findings and reported that levels of vitamin D over 30 ng/mL were associated with a decreased MS risk [86]. Adiposity has been associated with lower vitamin D levels [87][88], and higher body mass index (BMI) has been associated with higher incidence of MS in adolescent women, but not in adult women [89].…”

Section: Vitamin D Deficiency and Multiple Sclerosis: Role In The Susmentioning

confidence: 82%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

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Section: Vitamin D Deficiency and Multiple Sclerosis: Role In The Susmentioning

confidence: 82%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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“…Se han descrito otros factores asociados como la concentración de vitamina D y la exposición al sol, con reducción de la susceptibilidad al incremento de los niveles séricos de vitamina D. El tabaquismo, en el contexto de ciertos genes de HLA, tiene una fuerte influencia negativa en la susceptibilidad. 7,8,9,10 Respuesta inmune en EM: componentes de la respuesta inmunológica innata y adaptativa En el centro de la respuesta inmune de la EM se encuentra el componente células T CD4+. En el SNC están las células inmunes más importantes, las microglías, células propias de la respuesta inmune innata, sumamente sensibles a cambios y capaces de secretar mediadores solubles y presentar antígenos; sus procesos apendiculares se extienden lejos del cuerpo celular, disposición que les permite detectar cambios menores de las células adyacentes, como las neuronas y los astrocitos.…”

Section: Antecedentesunclassified

Esclerosis múltiple: aspectos inmunológicos actuales

Cuevas-García¹

2017

RAM

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Multiple sclerosis is the most common inflammatory, chronic and degenerative condition of the central nervous system, and represents the first cause of disability in young adults. In Mexico, 11 to 20 out of every 100 000 people suffer from this disease. The causes of multiple sclerosis remain unknown, but several theories have been proposed: the interaction of environmental factors, viral infectious factors and genetic and immune susceptibility of each individual patient, which induce an autoimmune response and promote neuronal/axonal degeneration. In this review, the immune reaction main components and neurodegeneration present in multiple sclerosis are analyzed, as well as the inflammatory cascade associated with demyelination. Available treatments' main purpose is to modulate aspects related to the adaptive immune response (B and T cells). The therapeutic challenge will be antigen-specific immune-tolerance induction, for example, with the use of tolerance protocols with peptides or DNA or nanoparticles vaccines. Future therapies should aim to control innate components (microglia, macrophages, astrocytes) and to promote remyelination. To optimize the treatment, a combined therapeutic approach targeting the control of inflammatory and neurodegenerative components of the disease and monitoring of biomarkers will be necessary.

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“…According to the results of our study, VitD deficiency influences greater percent of disability burden among MS patients. Many studies reported a negative correlation between serum VitD levels and disability [13][14][15][16][17].…”

Section: Disabilitymentioning

confidence: 99%

Quality of Life-Spasticity-Fatigue Score in Patients With Multiple Sclerosis and Serum Vitamin D Level

Özkan

2016

J Neurol Res

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Background: Vitamin D (VitD) is being increasingly studied in multiple sclerosis (MS). Association of VitD deficiency and MS risk, progression, disability and severity has been shown in previous studies. Our objective was to prospectively investigate if 25-hydroxyvitamin D (25(OH)D) levels are associated with duration of disease, the number of joint involvement, level of spasticity, and quality of life (QoL) in MS.

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Vitamin D as a protective factor in multiple sclerosis

Cited by 208 publications

References 29 publications

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Esclerosis múltiple: aspectos inmunológicos actuales

Quality of Life-Spasticity-Fatigue Score in Patients With Multiple Sclerosis and Serum Vitamin D Level

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