Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies

Kerley, Conor P; Elnazir, Basil; Faul, John L.; Cormican, Liam

doi:10.1016/j.pupt.2015.02.010

Cited by 38 publications

(51 citation statements)

References 176 publications

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“…In an animal study on diabetic rats, it was demonstrated that treatment with VD for 12 weeks increased the serum level of T in treatment groups. [26] In a clini- Abnormalities in calcium and phosphorus homeostasis [10,15] Bronchial asthma [4,7] Coronary artery disease [14,16] Erectile dysfunction [9,17,18] Heart failure [10,16] Hypertension [9,14] Hypogonadism [19][20][21][22] Impaired vascular endothelial and smooth muscle function [9,16] Increased immune or inflammatory response [23,24] Infertility [25,26] Metabolic syndrome [10,14,27] Osteoporosis [19,28,29] Peripheral vascular disease [15,30] Respiratory diseases [3,4] Wearing sunscreen clothes cal randomized controlled trial, which is the first on this topic in literature, Pilz et al [39] investigated the effect of VD supplementation on androgens in men. The results were significant and the researchers observed that overweight men with VDD had a clinically meaningful increase in serum T levels after VD supplementation for 1 year.…”

Section: Vitamin D and Endocrine Systemmentioning

confidence: 99%

“…[3][4][5][6] VD receptor is a member of the steroid receptor superfamily. Strikingly, over 3,000 genes are responsive to VD [7] and its biological effects are mediated through binding to the VD receptor and inducing either genomic or non-genomic downstream effects (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…Strikingly, over 3,000 genes are responsive to VD [7] and its biological effects are mediated through binding to the VD receptor and inducing either genomic or non-genomic downstream effects (Figure 1). [4,5,[8][9][10] Once bound with VD, the VD-receptor moiety translocates from the plasma membrane to the nucleus where it transcriptionally activates genes via the VD response element, thereby affecting transcription of other genes. [8] When a man is sexually stimulated, neuronal nitric oxide (NO) synthase is triggered, inducing a smooth muscle dilatory effect of NO, which is then, amplified by the release of endothelial NO synthase (eNOS) and endothelial stimulated release of additional NO.…”

Section: Introductionmentioning

confidence: 99%

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The role of vitamin D supplementation on erectile function

Talib

Khalafalla

Cangüven

2017

Turkish Journal of Urology

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In the last few years growing evidence highlighted vitamin D (VD) deficiency is one of the several dynamics that associates with increased atherosclerotic cardiovascular (ASCV) diseases. ASCV diseases and erectile dysfunction (ED) share common risk factors such as diabetes mellitus, hypertension, smoking, hyperlipidemia, and a sedentary lifestyle. The aim of this review was to summarize current progress in VD research by focusing effect of low VD level on different body systems and erectile function. Here we examine research linking VD deficiency and ED and discuss how VD influences ED and its classic risk factors that also associate to increased ED risk. We also summarize research indicating that VD associates with reduced risk of several nonvascular contributing factors for ED. Available literature demonstrates relatively high rates of low VD serum levels in ED patients. Based on the preclinical and clinical data available in the literature, to date, we infer that VD play a critical role in maintaining erectile function in humans. Nevertheless, this should also be tested through randomized controlled studies on the effect of VD supplementation with larger population.

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Section: Vitamin D and Endocrine Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of vitamin D supplementation on erectile function

Talib

Khalafalla

Cangüven

2017

Turkish Journal of Urology

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“…Humans may obtain vitamin D via two major sources: endogenous synthesis in the skin after UVB light exposure and diet (intake of vitamin D rich products such as fish, fish oils, egg yolk, liver and dietary supplements) [3,4]. In the skin, 7-dehydrocholesterol is converted to previtamin D due to action of UVB rays and then transformed to cholecalciferol via thermally induced isomerization.…”

Section: Vitamin D Synthesis Metabolism and Mechanism Of Actionmentioning

confidence: 99%

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Szymczak

Pawliczak

2018

Advances in Respiratory Medicine

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Asthma -a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients. Thus, it provides positive relation between vitamin D and asthma. Increased prevalence of asthma over the past decades causes elevated interest in vitamin D supplementation that is even reported as a ,,potential therapeutic option''. Unfortunately, results of clinical trials are inconsistent and do not provide supportive information about positive role of vitamin D in asthma. Little or even no effect of supplementation of vitamin D in improvement of onset, symptoms or progression of asthma was found in comprehensive interventional studies in adults, children and pregnant woman. This review critically summarized the last years evidence of a relation between vitamin D and asthma in adults, children and pregnant women.

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A randomized, double-blind, placebo-controlled of vitamin D3 for Irish children with asthma

et al. 2015

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We have recently reviewed that many mechanisms (1) and human studies (2) linking vitamin D deficiency (VDD) to asthma. Associations between vitamin D and both asthma/allergy appear stronger in children than adults (3) , with some even suggesting that childhood asthma may be caused by VDD (4) . Conversely, an alternative hypothesis suggests increased vitamin D status is associated with increased asthma/allergy incidence and severity (5) . In line with these opposing theories, several recent randomized trials of vitamin D supplementation in paediatric asthma have demonstrated inconsistent results. We wanted to assess the effects of vitamin D 3 supplementation on subjective asthma measures, lung function, biomarkers of inflammation/allergy and self-reported exacerbation/ infection rate in Caucasian, asthmatic children residing at high latitude over the winter season.After obtaining ethical approval, we conducted a 15 week double-blind, randomized, placebo-controlled trial of vitamin D supplementation (2,000IU/d) in 44 urban, Caucasian children at high latitude (Ireland, 53°N). Assessments were completed at baseline and after 15 weeks. The primary outcome was change in paediatric asthma control test (P-ACT). Secondary outcomes included lung function using computerized spirometry, subjective asthma control (GINA score, mini paediatric asthma quality of life questionnaire) and biochemical parameters of serum vitamin D (25(OH)D), allergy (total IgE), systemic inflammation (high sensitivity CRP), airway inflammation (eosinophil cationic protein), immunity (IgA) and bone homeostasis (parathyroid hormone, albumin corrected calcium, phosphate). Finally, parents/gaurdians completed a weekly diary during the trial regarding infection and exacerbation frequency. 39 children completed the trial. There was no significant differences in 25(OH)D levels at baseline. At follow up, 25(OH)D increased significantly in the vitamin D 3 group (57 to 104 nmol/L) compared to the placebo group (53 to 58 nmol/L) (p < 0·0001). There was no significant change in our primary endpoint (P-ACT) or secondary endpoints. However, there were non-significant, advantageous changes in the placebo group compared to the vitamin D group in subjective asthma control, inflammation and lung function, particularly FEV 1 % (+1·8 vs −4·5; p = 0·06).Vitamin D 3 supplementation (2,000IU/d) for 15 weeks led to a significant increase in serum 25(OH)D, but this change was not accompanied by significant changes in asthma control.

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Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies

Cited by 38 publications

References 176 publications

The role of vitamin D supplementation on erectile function

The role of vitamin D supplementation on erectile function

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

A randomized, double-blind, placebo-controlled of vitamin D3 for Irish children with asthma

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