Vitamin D as an immune modulator in multiple sclerosis

Bartosik-Psujek, Halina; Psujek, Marek

doi:10.5603/pjnns.a2019.0015

Cited by 20 publications

(17 citation statements)

References 85 publications

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“…Exposure to the sun and vitamin D are environmental factors that have been widely associated with MS development and activity [ 192 ]. Vitamin D seems to be an intermediary between the two since UVB produces this vitamin under physiological mechanisms [ 4 ].…”

Section: Environmental Factorsmentioning

confidence: 99%

“…25(OH)D3 is converted into 1,25(OH)2D3 (calcitriol), the active metabolite, through a second hydroxylation that takes place in the kidneys. Through binding to the intracellular vitamin D receptor (VDR), 1,25(OH)2D3 exerts its biological effects [ 192 ]. All immune cells express VDR, thus vitamin D influences innate and adaptive immunity, mainly shifting the immune response toward an anti-inflammatory one [ 195 ].…”

Section: Environmental Factorsmentioning

confidence: 99%

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Identifying the culprits in neurological autoimmune diseases

Acosta-Ampudia

Monsalve

Ramírez-Santana

2019

Journal of Translational Autoimmunity

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The target organ of neurological autoimmune diseases (NADs) is the central or peripheral nervous system. Multiple sclerosis (MS) is the most common NAD, whereas Guillain-Barré syndrome (GBS), myasthenia gravis (MG), and neuromyelitis optica (NMO) are less common NADs, but the incidence of these diseases has increased exponentially in the last few years. The identification of a specific culprit in NADs is challenging since a myriad of triggering factors interplay with each other to cause an autoimmune response. Among the factors that have been associated with NADs are genetic susceptibility, epigenetic mechanisms, and environmental factors such as infection, microbiota, vitamins, etc. This review focuses on the most studied culprits as well as the mechanisms used by these to trigger NADs.

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Section: Environmental Factorsmentioning

confidence: 99%

Section: Environmental Factorsmentioning

confidence: 99%

Identifying the culprits in neurological autoimmune diseases

Acosta-Ampudia

Monsalve

Ramírez-Santana

2019

Journal of Translational Autoimmunity

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“…Multiple sclerosis (MS) is known as a neurodegenerative autoimmune disorder with a range of manifestations such as inflammatory lesions and demyelination in central nervous system (CNS) (1). It is responsible for substantial disabilities and causes considerable social and economic problems all around the world (2).…”

mentioning

confidence: 99%

The effect of calcitriol and all‐trans retinoic acid on T‐bet, IFN‐γ, GATA3 and IL‐4 genes expression in experimental autoimmune encephalomyelitis

Parastouei

Solaymani-Mohammadi

Shiri-Shahsavar

et al. 2020

APMIS

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Multiple sclerosis (MS) is an immune-mediated inflammatory disease which affects the central nervous system (CNS). In the present study, the in vivo effects of ATRA, calcitriol, and their combinations on the expression of murine CD4+ T cell cytokines and their specific transcription factors in experimental autoimmune encephalomyelitis (EAE)-induced mice were explored. Thirty-two EAE induced inbred C57BL/6 female mice with an age ranged from 8 to 10 weeks were divided into four categories in a random manner. The first, second, and third groups received ATRA, calcitriol, ATRA+ calcitriol, respectively, and the fourth group received vehicle. The treatment started on the day prior to immunization and through the IP injections every other days for 21 days. The dosages of administration for calcitriol, ATRA, and calcitriol+ ATRA were 100 ng, 250 lg, and 50ng + 125 lg, respectively per mouse. An equal volume of excipient was administered for the vehicle group. T-bet, IFN-c, GATA-3, and IL-4 genes expression were assessed in the splenocytes of EAE-induced mice. The expression of T-bet and IFN-c genes in the splenocytes of ATRA, calcitriol and combination-treated mice were significantly reduced compared to vehicle group (p < 0.05). A significant decrease in T-bet expression was observed in the combination-treated group compared to the ATRA-treated group (p < 0.05). The expression of GATA3 and IL-4 genes was significantly increased in the ATRA-, calcitriol-, and combination-treated mice when compared with the control group (p < 0.05). Furthermore, the effect of calcitriol alone and in combination with ATRA was more considerable than that of ATRA alone. The nutraceutical approaches may be promising in the prevention and/or treatment of MS.

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“…The PJNNS has excellent download metrics. The five most downloaded articles are listed in multiple sclerosis patients [2]. The second most downloaded article was a research paper submitted by authors from the Municipal Hospital in Nysa and the Opole University of Technology, both institutions located in Poland.…”

mentioning

confidence: 99%

“…[2][3][4][5][6]. The most frequently downloaded article was an invited review written by authors from the University of Rzeszow in Poland.…”

mentioning

confidence: 99%