Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index

Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Butler, Alexandra E.; Atkin, Stephen L.

doi:10.1186/s12967-021-02897-0

Cited by 5 publications

(23 citation statements)

References 13 publications

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“…In relation to PAI-1, an inverse association between vitamin D and PAI-1 levels was reported both in the study of Blondon et al 42 and in that of Moin et al 45 However, this association was not detected by Topaloglu et al 49 The presence of a possible link between vitamin D and PAI-1 levels is supported not only by in vitro studies reporting an ability of vitamin D to reduce PAI-1 expression in different cell lines 67 68 69 but also by the results of a RCT from Witham et al, 58 showing a significant reduction in PAI-1 after vitamin D supplementation compared with placebo. However, no such difference has been found in the other five RCTs and intervention studies investigating this same association.…”

Section: Discussionmentioning

confidence: 80%

“…fibrinogen and vitamin D levels after adjusting for potential confounders, nor did the comparative cross-sectional study by Moin et al 45 Furthermore, no statistically significant changes in fibrinogen levels were induced either by vitamin D supplementation 44,55 or indirect vitamin D induction by means of artificial UV radiation. 50…”

Section: Fibrinogenmentioning

confidence: 84%

“…Fifteen of the included studies examined the relationship between vitamin D levels and one or more of the fibrinolytic parameters. 42 44 45 46 47 49 50 52 53 54 55 56 57 58…”

Section: Resultsmentioning

confidence: 99%

“…In fact, two cross-sectional studies by Hyppönen et al 46 and Jorde et al 47 reported a significant reduction in tPA levels with increasing levels of vitamin D. This was further supported by the RCT published by Witham et al, 58 who found a significant reduction in tPA levels after vitamin D supplementation. However, such association was not observed in the RCT by Jorde et al 52 In relation to PAI-1, an inverse association between vitamin D and PAI-1 levels was reported both in the study of Blondon et al 42 and in that of Moin et al 45 However, this association was not detected by Topaloglu et al 49 The presence of a possible link between vitamin D and PAI-1 levels is supported not only by in vitro studies reporting an ability of vitamin D to reduce PAI-1 expression in different cell lines [67][68][69] but also by the results of a RCT from Witham et al, 58 showing a significant reduction in PAI-1 after vitamin D supplementation compared with placebo. However, no such difference has been found in the other five RCTs and intervention studies investigating this same association.…”

Section: Fibrinolysismentioning

confidence: 89%

“…F1 + 2 and TAT were mostly found not to be related to vitamin D levels in the included studies. 44 45 47 48 50 53 Only the cross-sectional study by Da Porto et al 48 reported a relationship of serum vitamin D levels with F1 + 2, but the study population consisted of patients with symptomatic peripheral artery disease.…”

Section: Discussionmentioning

confidence: 99%

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Is Vitamin D Deficiency Prothrombotic? A Systematic Review

Rüdiger

Andersen

Vestergaard

et al. 2022

Semin Thromb Hemost

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Observational studies indicate a relationship between vitamin D deficiency and an increased risk of venous and arterial thrombotic events, but the underlying mechanisms behind this association are uncertain. This systematic review explores if there is an association between decreased vitamin D levels and a prothrombotic profile. The systematic literature search initially identified 3,214 studies (published until December 21, 2021) investigating the relationship between vitamin D and numerous hemostatic parameters. After the screening process, 18 observational and intervention studies fulfilled the inclusion criteria and were included in this systematic review. Parameters of primary hemostasis, secondary hemostasis, and fibrinolysis were investigated in six, thirteen, and fifteen of these studies, respectively. Most of the eligible studies did not identify significant associations between decreased vitamin D levels and hemostatic parameters. Some conflicting results were found between decreased vitamin D levels and thrombin generation parameters and the tissue factor pathway inhibitor. Conflicting results were also found between decreased vitamin D levels and fibrinolytic parameters, although the evidence may point toward weak associations with some regulators of fibrinolysis, mostly decreased tissue type plasminogen activator. Overall, our systematic review did not identify any definitive link between vitamin D deficiency and a prothrombotic profile, which might otherwise help explain the observed association between vitamin D deficiency and increased risk of thrombotic events. Moreover, there is no clinical evidence to confirm or refute a possible antithrombotic effect of vitamin D. Larger high-quality randomized controlled trials are needed to better elucidate the link between vitamin D deficiency and a prothrombotic risk profile.

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Section: Discussionmentioning

confidence: 80%

Section: Fibrinogenmentioning

confidence: 84%

“…Fifteen of the included studies examined the relationship between vitamin D levels and one or more of the fibrinolytic parameters. 42 44 45 46 47 49 50 52 53 54 55 56 57 58…”

Section: Resultsmentioning

confidence: 99%