Vitamin D attenuates DNCB-induced atopic dermatitis-like skin lesions by inhibiting immune response and restoring skin barrier function

Lu, Renwei; Peng, Ziqi; Lian, Panpan; Wazir, Junaid; Gu, Cheng; Ma, Chujun; Wei, Lulu; Li, Li; Pu, Wenyuan; Li, Jun; Wang, Hongwei; Su, Zhonglan

doi:10.1016/j.intimp.2023.110558

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…Calcitriol, the active form of Vitamin D, exerts its biological effects by binding to VDR. Topical application of calcitriol has been proven to improve barrier function by increasing loricrin and filaggrin expression, making it a safe and effective treatment for both AD and psoriasis 129–131 . In addition, the augmentation of VDR expression through topical application of calcitriol facilitates the repair of impaired epidermal barrier induced by corticosteroids 100 …”

Section: Nrs Related Skin Diseases and Emerging Therapeutic Modalitiesmentioning

confidence: 99%

Nuclear receptors for epidermal lipid barrier: Advances in mechanisms and applications

Yin,

Yan,

et al. 2024

Experimental Dermatology

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The skin plays an essential role in preventing the entry of external environmental threats and the loss of internal substances, depending on the epidermal permeability barrier. Nuclear receptors (NRs), present in various tissues and organs including full‐thickness skin, have been demonstrated to exert significant effects on the epidermal lipid barrier. Formation of the lipid lamellar membrane and the normal proliferation and differentiation of keratinocytes (KCs) are crucial for the development of the epidermal permeability barrier and is regulated by specific NRs such as PPAR, LXR, VDR, RAR/RXR, AHR, PXR and FXR. These receptors play a key role in regulating KC differentiation and the entire process of epidermal lipid synthesis, processing and secretion. Lipids derived from sebaceous glands are influenced by NRs as well and participate in regulation of the epidermal lipid barrier. Furthermore, intricate interplay exists between these receptors. Disturbance of barrier function leads to a range of diseases, including psoriasis, atopic dermatitis and acne. Targeting these NRs with agonists or antagonists modulate pathways involved in lipid synthesis and cell differentiation, suggesting potential therapeutic approaches for dermatosis associated with barrier damage. This review focuses on the regulatory role of NRs in the maintenance and processing of the epidermal lipid barrier through their effects on skin lipid synthesis and KC differentiation, providing novel insights for drug targets to facilitate precision medicine strategies.

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Section: Nrs Related Skin Diseases and Emerging Therapeutic Modalitiesmentioning

confidence: 99%

Nuclear receptors for epidermal lipid barrier: Advances in mechanisms and applications

Yin,

Yan,

et al. 2024

Experimental Dermatology

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“…Vitamin D is a lipid soluble cyclopentane polyhydrophenanthrene compound as a kind of special organic active regulators which is indispensable to the human body by regulating calcium and phosphorus metabolism [1,2], promoting bone growth [3], regulating cell growth and differentiation [4,5], and regulating immune response [6,7].…”

Section: Introductionmentioning

confidence: 99%

The epidemiological investigation of vitamin D deficiency in northern Henan province

Deng,

Lin,

Yang

2023

Preprint

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Aim/purposeTo analyze the epidemiology of vitamin D deficiency in northern Henan province, to lay the foundation for prevention and treatment of vitamin D deficiency and the vitamin D related diseases.MethodsWe collected the basic information including gender, age, and vitamin D concentration of 22184 people who detected the 25 hydroxyvitamin D concentration in the Third Affiliated Hospital of Xinxiang Medical University from June 2020 to May 2023, analyzed the vitamin D deficiency distribution in male children population, female children population, male adult population and female adult population; and the differences of 25 hydroxyvitamin D concentration of diabetes mellitus patients in the total investigation population in northern Henan province were also analyzed and compared according to gender, age and different seasons.ResultsA total of 22184 data were collected from June 2020 to May 2023 in the Third Affiliated Hospital of Xinxiang Medical University; the age range of investigation objects was from 1 month to 93 years old; there were 8176 male people and 14008 female people, accounting for 36.86% and 63.14% in the total investigation population, respectively; there were 1318 diabetes mellitus patients, accounting for 5.94% in the total investigation population; there were 796 males and 522 females, accounting for 60.39% and 39.61% in the total 1318 diabetes mellitus patients, respectively; the investigation results demonstrated that the number of people with vitamin deficiency was 278, the number of people with vitamin insufficiency was 1418, and the number of people with normal vitamin concentration was 20488, accounting for 1.25%, 6.39% and 92.35% in the total investigation population, respectively; in the adult female population, the number of people with vitamin deficiency and with vitamin insufficiency were highest compared the male children population, female population and male adult population; the statistical results demonstrated that there were the significantly statistical differences among vitamin D concentration<25nmol/mL population, vitamin D concentration at 25-49 nmol/mL population, and vitamin D concentration at 50∼80 nmol/mL in female adult population at the different age (P=0.0039); and there were no statistical differences in male children population, male adult population and female children population at different ages and at different vitamin D concentrations (P>0.05); the results demonstrated that there were the significantly differences among vitamin D concentration<25nmol/mL population, vitamin D concentration at 25-49 nmol/mL population, and vitamin D concentration at 50∼80 nmol/mL in adult diabetes mellitus population at gender, age and different seasons.92.35% people in northern Henan province had the normal vitamin concentration, there were 7.65% people with vitamin insufficiency or vitamin deficiency in northern Henan province; the number of people with vitamin deficiency and with vitamin insufficiency were highest in the adult female population, and there were the significantly statistical differences in female adult population at the different age at different vitamin concentration population and in diabetes mellitus adult population at gender, age and different seasons.ConclusionThe incidence rate of vitamin insufficiency or vitamin deficiency in northern Henan province was 7.65%, and the epidemiology of vitamin D deficiency in northern Henan province had the specific characteristics. Those evidences may provide useful information for prevention and treatment of vitamin D deficiency and vitamin D related diseases.

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Air pollution and skin diseases: A comprehensive evaluation of the associated mechanism

Gu,

Li,

2024

Ecotoxicology and Environmental Safety

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Vitamin D attenuates DNCB-induced atopic dermatitis-like skin lesions by inhibiting immune response and restoring skin barrier function

Cited by 5 publications

References 26 publications

Nuclear receptors for epidermal lipid barrier: Advances in mechanisms and applications

Nuclear receptors for epidermal lipid barrier: Advances in mechanisms and applications

The epidemiological investigation of vitamin D deficiency in northern Henan province

Air pollution and skin diseases: A comprehensive evaluation of the associated mechanism

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