2018
DOI: 10.1186/s13104-018-3725-7
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Vitamin D binding protein is not affected by high-dose vitamin D supplementation: a post hoc analysis of a randomised, placebo-controlled study

Abstract: ObjectivesVitamin D binding protein (VDBP) is the main transporter of 25-hydroxyvitamin D3 (25-OHD) in the circulation. The aim of this study was to investigate if VDBP is affected by high dose vitamin D supplementation and if VDBP-levels correlate with free 25-OHD. Correlation between free 25-OHD measured with ELISA and total 25-OHD in the circulation was also analysed. Plasma samples from a randomized, controlled trial in which persistent MRSA-carriers were randomized to treatment with vitamin D, 4000 IE/day… Show more

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Cited by 22 publications
(10 citation statements)
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“…Moreover, we also found that total 25(OH)vitD is not related to either DBP or albumin concentration; they are independent variables. This is consistent with the concept that vitD itself or its metabolites do not regulate DBP production [19,38]. Previous studies also reported lower serum albumin concentrations in PAH patients [39,40] and in PAH animal models [41], suggesting that reduced albumin may be a risk factor for PAH.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…Moreover, we also found that total 25(OH)vitD is not related to either DBP or albumin concentration; they are independent variables. This is consistent with the concept that vitD itself or its metabolites do not regulate DBP production [19,38]. Previous studies also reported lower serum albumin concentrations in PAH patients [39,40] and in PAH animal models [41], suggesting that reduced albumin may be a risk factor for PAH.…”
Section: Discussionsupporting
confidence: 90%
“…Moreover, free or bioavailable 25(OH)vitD measurements are highly difficult, and, at this moment, there is only one immunoassay for the direct measurement of free 25(OH)vitD [45]. Some authors suggest that, if there is a correlation between bioavailable and/or free 25(OH)vitD with total 25(OH)vitD, it would only be necessary to measure total 25(OH)vitD [38].…”
Section: Discussionmentioning
confidence: 99%
“…However, there was not a concentration-dependent linear relationship between 1,25(OH)2D3 concentration and VDBP expression. On the other hand, this suggests that the effect of VD+VDBP on the viability and apoptosis of RASFs may be mainly mediated by the externally added VDBP but not the VDBP induced by vitamin D. Our result was in part inconsistent with the previous result that oral administration of large doses of vitamin D did not increase VDBP level in circulation ( 36 ). This may because different experimental systems were used.…”
Section: Discussioncontrasting
confidence: 99%
“…Primary hyperparathyroidism, on the other hand, is associated with a reduction in DBP levels, likely contributing to the lower 25(OH)D levels in these patients as the free 25(OH)D is not reduced (9). Vitamin D itself or any of its metabolites do not regulate DBP production (10).…”
Section: Vitamin D Binding Proteinmentioning
confidence: 99%