Vitamin D deficiency accelerates ageing and age‐related diseases: a novel hypothesis

Berridge, Michael J.

doi:10.1113/jp274887

Cited by 119 publications

(88 citation statements)

References 195 publications

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“…Vitamin D has also been linked to distinct components of the ageing process ( Figure 2). The negative acute phase reactant vitamin D [90] mitigates oxidative stress at least in part through increased expression of anti-oxidant regulators, including NRF2 and klotho [91][92][93]. Thus, calcitriol increased renal and circulating klotho expression, whereas it reduced markers of oxidative stress in uninephrectomized, spontaneously hypertensive rats [94].…”

Section: The Endocrine Phosphate-fgf-23-klotho Axis and Premature Agementioning

confidence: 99%

Inflammation and Premature Ageing in Chronic Kidney Disease

Ebert

Pawelzik

Witasp

et al. 2020

Toxins

163

122

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Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life, and premature mortality in chronic kidney disease (CKD). Because there is a huge global burden of disease due to CKD, treatment strategies targeting inflammation and premature ageing in CKD are of particular interest. Several distinct features of the uremic phenotype may represent potential treatment options to attenuate the risk of progression and poor outcome in CKD. The nuclear factor erythroid 2-related factor 2 (NRF2)–kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein 1 (KEAP1) signaling pathway, the endocrine phosphate-fibroblast growth factor-23–klotho axis, increased cellular senescence, and impaired mitochondrial biogenesis are currently the most promising candidates, and different pharmaceutical compounds are already under evaluation. If studies in humans show beneficial effects, carefully phenotyped patients with CKD can benefit from them.

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Section: The Endocrine Phosphate-fgf-23-klotho Axis and Premature Agementioning

confidence: 99%

Inflammation and Premature Ageing in Chronic Kidney Disease

Ebert

Pawelzik

Witasp

et al. 2020

Toxins

163

122

View full text Add to dashboard Cite

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“…Therefore, those who have vitamin D deficiency are usually more susceptible to suffering from different pathologies associated with age such as Parkinson's disease, Alzheimer's, and cardiovascular disease, among others. On the other hand, subjects with normal plasma levels of vitamin D are generally less likely to suffer any of the diseases mentioned [103][104][105]. It has also been indicated that vitamin D deficiency is related to a decrease in the expression of VDR and an altered activity of antioxidant enzymes at the skeletal muscle level.…”

Section: Effects Of Vitamin D In the Attenuation Of Mitochondrial Oximentioning

confidence: 99%

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

et al. 2020

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Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has put the health of the world population on alert. COVID-19 can provoke an acute inflammatory process and uncontrolled oxidative stress, which predisposes one to respiratory syndrome, and in the worst case, death. Recent evidence suggests the mechanistic role of mitochondria and vitamin D in the development of COVID-19. Indeed, mitochondrial dynamics contribute to the maintenance of cellular homeostasis, and its uncoupling involves pathological situations. SARS-CoV-2 infection is associated with altered mitochondrial dynamics with consequent oxidative stress, pro-inflammatory state, cytokine production, and cell death. Furthermore, vitamin D deficiency seems to be associated with increased COVID-19 risk. In contrast, vitamin D can normalize mitochondrial dynamics, which would improve oxidative stress, pro-inflammatory state, and cytokine production. Furthermore, vitamin D reduces renin–angiotensin–aldosterone system activation and, consequently, decreases ROS generation and improves the prognosis of SARS-CoV-2 infection. Thus, the purpose of this review is to deepen the knowledge about the role of mitochondria and vitamin D directly involved in the regulation of oxidative stress and the inflammatory state in SARS-CoV-2 infection. As future prospects, evidence suggests enhancing the vitamin D levels of the world population, especially of those individuals with additional risk factors that predispose to the lethal consequences of SARS-CoV-2 infection.

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“…Epidermal AMPs like cathelicidin (hBD18) expressed in keratinocytes is induced by 1,25 (OH) 2 vitamin D3 from 7-dehydrocholesterol and protects the skin against pathogens ( 8 , 206 , 207 ). Vitamin D promotes autophagy (ATG16L1 in autoimmune disorders like inflammatory bowel disorder) and suppresses pro-inflammatory pathways (such as p38 MAPK-mediated signaling pathway, prostaglandin pathway, nuclear factor kappa B signaling pathway) ( 206 , 208 , 209 ).…”

Section: Skin Exposures and Autophagymentioning

confidence: 99%

More Than Skin Deep: Autophagy Is Vital for Skin Barrier Function

2018

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The skin is a highly organized first line of defense that stretches up to 1.8 m2 and is home to more than a million commensal bacteria. The microenvironment of skin is driven by factors such as pH, temperature, moisture, sebum level, oxidative stress, diet, resident immune cells, and infectious exposure. The skin has a high turnover of cells as it continually bares itself to environmental stresses. Notwithstanding these limitations, it has devised strategies to adapt as a nutrient-scarce site. To perform its protective function efficiently, it relies on mechanisms to continuously remove dead cells without alarming the immune system, actively purging the dying/senescent cells by immunotolerant efferocytosis. Both canonical (starvation-induced, reactive oxygen species, stress, and environmental insults) and non-canonical (selective) autophagy in the skin have evolved to perform astute due-diligence and housekeeping in a quiescent fashion for survival, cellular functioning, homeostasis, and immune tolerance. The autophagic “homeostatic rheostat” works tirelessly to uphold the delicate balance in immunoregulation and tolerance. If this equilibrium is upset, the immune system can wreak havoc and initiate pathogenesis. Out of all the organs, the skin remains under-studied in the context of autophagy. Here, we touch upon some of the salient features of autophagy active in the skin.

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Vitamin D deficiency accelerates ageing and age‐related diseases: a novel hypothesis

Cited by 119 publications

References 195 publications

Inflammation and Premature Ageing in Chronic Kidney Disease

Inflammation and Premature Ageing in Chronic Kidney Disease

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

More Than Skin Deep: Autophagy Is Vital for Skin Barrier Function

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