Vitamin D deficiency among subfertile women: case-control study

Al‐Jaroudi, Dania; Albanyan, Nora; Aljohani, Naji; Kaddour, Ouhoud; Al-Tannir, Mohamad

doi:10.3109/09513590.2015.1112784

Cited by 16 publications

(7 citation statements)

References 23 publications

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“…Very low vitamin D levels may thus characterize women with primary infertility according to “autoimmune mechanisms” of the pregnancy failure . Similar results were reported by Al‐Jaroudi et al, showing a significant higher degree of vitamin D deficiency in subfertile women in comparison with controls. Pagliardini et al .…”

Section: Discussionsupporting

confidence: 85%

Vitamin D deficiency in an Italian cohort of infertile women

Triggianese

Watad

Cedola

et al. 2017

American J Rep Immunol

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Section: Discussionsupporting

confidence: 85%

Vitamin D deficiency in an Italian cohort of infertile women

Triggianese

Watad

Cedola

et al. 2017

American J Rep Immunol

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“…reported a significantly higher serum Vitamin D level in infertile women compared to pregnant women in Saudi Arabia. [ 31 ] Contrary to this study, researchers in Iraq found infertile women had a higher proportion of Vitamin D deficiency and insufficiency than fertile women. [ 32 ] The contradiction with the results of this study may be due to the inclusion of lactating women among the fertile group.…”

Section: Discussioncontrasting

confidence: 64%

Does the Serum Vitamin D Status and its Possible Effect on Serum Anti-Müllerian Hormone Levels Predict Fertility in Premenopausal Women?

Lawal

2021

Journal of Human Reproductive Sciences

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Context: Evidence suggests that serum Vitamin D level influences female reproduction. However, clinical studies have reported conflicting evidence on the effect of serum Vitamin D levels on serum Anti-Müllerian hormone (AMH), with little evidence in African women. Aim: The study aimed to compare the relationship between serum Vitamin D and serum AMH among infertile and fertile women. Settings and Design: This comparative cross-sectional study analyzed data from 170 premenopausal women; 81 infertile, and 89 fertile women attending a Nigerian tertiary hospital between March and June 2019. Materials and Methods: Serum AMH and 25-hydroxyvitamin D (25(OH) Vitamin D) concentrations were analysed using enzyme-linked immunosorbent assay. Statistical Analysis: Statistical analysis was done using SPSS version 25 for windows. Categorical variables were summarized in frequencies and proportions while continuous variables were summarized in means ± standard deviation and median (interquartile range). The association was explored using linear regression. The level of significance was set at 0.05. Results: The prevalence of Vitamin D deficiency (<20 ng/ml) in infertile women and fertile women was 16% and 18%, respectively. There was no difference in serum Vitamin D levels between infertile and fertile women in this study after controlling for age and body mass index (BMI) ( P = 0.186). There was no association between serum 25(OH) Vitamin D and serum AMH in infertile (B = 0.002; P = 0.474) and fertile women (B = ‒0.002; P = 0.522) after adjusting for age and BMI. Conclusion: Infertile and fertile women had similar serum Vitamin D levels and there was no relationship between serum Vitamin D and serum AMH in both infertile and fertile women.

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“…Our study demonstrated that most infertile women had insufficient 25(OH)VD levels ( Table 1 ). Indeed, average serum 25(OH)VD levels in subfertile women were reportedly lower than those in normal fertile women [ 32 , 33 ]. In northern European countries, seasonal variation in conception rates was attributed to changes in the VD levels with the sunlight exposure; as such, VD status was strongly associated with the conception rate [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Regulates Maternal T-Helper Cytokine Production in Infertile Women

Ikemoto

Kuroda

Nakagawa³

et al. 2018

Nutrients

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Vitamin D (VD) deficiency is associated with reproductive failure. However, the relationship between VD and maternal immunity remains unclear. We investigated the clinical efficacy of VD in maternal T-helper (Th) cytokines in 276 infertile women and examined for Th1 and Th2 cells based on the deficient, insufficient, and sufficient serum 25-hydroxyvitamin D3 (25[OH]VD) levels (<12, 12–30, and >30 ng/mL, respectively). Most infertile women had a low-level of VD (87.3%). Immunological tests of pre-/post-VD supplementation were performed in patients who were deficient and insufficient in VD. Of 23 patients, 11 (47.8%) exhibited sufficient VD levels after supplementation. Th1/Th2 cell ratio in patients with insufficient VD was significantly decreased after supplementation (p = 0.004). After supplementation, serum 25(OH)VD levels of the patients: 11 in the sufficient group showed significant decreases in Th1 cell level and Th1/Th2 cell ratio (p = 0.032 and 0.010, respectively), whereas no significant differences in Th1/Th2 cell ratio were recognized in the insufficient group. Furthermore, mid-luteal endometrial biopsies (n = 18) were processed for primary cultures and measured interferon [IFN]-γ and interleukin [IL]-4 in condition media. Decidualizing cultures with 1,25-dihydroxvitamin D3 (1,25[OH]2VD) decreased IFN-γ. Sufficient VD supplementation in women with insufficient VD may optimize maternal T-helper cytokines during pregnancy via rebalancing the Th1/Th2 cell ratio.

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Vitamin D deficiency among subfertile women: case-control study

Abstract: Vitamin D deficiency is prevalent among subfertile women. Optimization of serum calcium and vitamin D levels is encouraged.

Cited by 16 publications

References 23 publications

Vitamin D deficiency in an Italian cohort of infertile women

Vitamin D deficiency in an Italian cohort of infertile women

Does the Serum Vitamin D Status and its Possible Effect on Serum Anti-Müllerian Hormone Levels Predict Fertility in Premenopausal Women?

Vitamin D Regulates Maternal T-Helper Cytokine Production in Infertile Women

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