Vitamin D deficiency among Type 2 Diabetes patients in Saudi Arabia: a systematic review

Albannawi, Gadeer A; Alsaif, Sajidah Bader; Alsaif, Ghofran; B, Taher

doi:10.24911/ijmdc.51-1573214220

Cited by 8 publications

(14 citation statements)

References 27 publications

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“…Untreated T2DM can lead to several comorbidities, including micro-and macro-vascular complications. One of the major risk factors for CAD is diabetes mellitus (30,1). HIFs have a role in the progression of β cell dysfunction and diabetes.…”

Section: Discussionmentioning

confidence: 99%

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Relation of Hypoxia Inducible Factor, Dyslipidemia and CAD Saudi Patients With Type 2 Diabetes

Gharib

Saber

Askary

et al. 2022

In Vivo

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Background/Aim: Type 2 diabetes (T2DM) is a metabolic condition associated with an increased risk of death, morbidity, and vascular problems. This study investigated the association of HIF-1α and dyslipidemia with the incidence of coronary artery disease in Saudi patients with T2DM. Patients and Methods: This study included 100 Saudi patients aged 40-60 years who were attending King Abdulaziz Specialist Hospital in Taif, as well as 50 healthy controls. All were divided into three groups of 50 subjects each: control, patients with T2DM, and patients with T2DM with coronary complications. Serum levels of HIF-1α, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c %), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were estimated. Results: Serum HIF-1α,

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Section: Discussionmentioning

confidence: 99%

“…Its prevalence has increased dramatically in developing countries. The number of people with T2DM is projected to more than double by 2030, reaching 366 million people worldwide (1). The prevalence of diabetes in Saudi Arabia is the second highest in all of the Middle Eastern countries and ranks seventh worldwide (2).…”

mentioning

confidence: 99%

Relation of Hypoxia Inducible Factor, Dyslipidemia and CAD Saudi Patients With Type 2 Diabetes

Gharib

Saber

Askary

et al. 2022

In Vivo

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“… 18 The probability of developing T2DM was substantially high in both males and females and it has been suggested that 25-OH D deficiency might contribute to T2DM development. 19 Vitamin D deficiency is suggested to be one of the factors that influence many processes involved in T2DM. 20 Vitamin B12 deficiency-associated peripheral neuropathy can also remain subclinical and interact with T2DM.…”

Section: Introductionmentioning

confidence: 99%

Association of lncRNA LINC01173 Expression with Vitamin-D and Vitamin B12 Level Among Type 2 Diabetes Patients

Aladel¹,

Verma²,

Dabeer³

et al. 2022

DMSO

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Background Type 2 diabetes mellitus (T2DM) has risen to become the world’s most serious public health problem in recent years, and the role of long noncoding RNAs (lncRNAs) in the onset and progression of T2DM, as well as special attention to vitamins, has gotten a lot of attention recently. Methods The aim of the study was to analyze lncRNA LINC01173 expression along with assessment of vitamin-D and B12 among the T2DM cases. Quantitative RT-PCR was used to analyze the expression of lncRNA LINC01173. Vitamin-D and B12 were analyzed by chemiluminescence-based assay. Results The present study observed that the T2DM cases had 6.67-fold increased lncRNA LINC01173 expression compared to healthy controls. Expression of lncRNA LINC01173 was found to be associated with hypertension ( p =0.03), wound healing ( p =0.04), and blurred vision ( p <0.0001). It was observed that the T2DM cases with vitamin-D deficiency had a significant association with fasting glucose level ( p =0.01) and HbA1C level ( p =0.01) among the T2DM cases. The association of lncRNA LINC01173 with vitamin-D was analyzed and it was observed that the vitamin-D deficient cases had higher lncRNA LINC01173 expression compared to insufficient T2DM cases ( p =0.01) and sufficient T2DM cases ( p =0.0006). It was also observed that the T2DM cases with smoking had a 8.33-fold lncRNA LINC01173 expression while non-smokers had a 5.43-fold lncRNA LINC01173 expression ( p <0.0001). Conclusion The study concluded that the increased lncRNA LINC01173 expression was observed to be linked with alteration in vitamin-D level and smoking habit. Altered expression of lncRNA LINC01173 expression was linked with fasting glucose and HbA1C alteration. Collectively, lncRNA LINC01173 expression, vitamin-D alteration, as well as smoking habit may cause the disease severity and increase the pathogenesis of disease.

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“…In developing countries, its prevalence has risen considerably. By 2030, the number of persons with T2DM is expected to be more than doubled, with 366 million people worldwide (1).…”

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confidence: 99%

“…According to a study conducted to discover the association between 25-OH D and T2DM, the probability of developing T2DM was substantially lower in both sexes (40-74 years of age) in the case of highest serum 25-OH D as matched to the lowest level. It has been proposed that 25-OH D deficiency might contribute to T2DM development (1). 25-OH D is considered to affect CAD through a variety of processes, including carbohydrate and fat metabolic abnormalities.…”

mentioning

confidence: 99%

Association of Vitamin D Deficiency and Vitamin D Receptor Genetic Variants With Coronary Artery Disease in Type 2 Diabetic Saudi Patients

Shafie¹,

Askary²,

Almehmadi³

et al. 2022

In Vivo

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Background/Aim: Vitamin D deficiency accelerates the onset of type 2 diabetes mellitus (T2DM). Polymorphisms in the vitamin D receptor (VDR) have been linked to coronary artery disease (CAD). This study aimed to evaluate the association of vitamin D deficiency and VDR polymorphism with CAD in T2DM. Patients and Methods: A total of 150 adult male and female subjects, aged from 40 to 60 years, were divided into three groups, each with 50 subjects; control group, T2DM, and T2DM with CAD. Fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, glycosylated hemoglobin (HbA1c), and 25-hydroxyvitamin D (25-OH D) were assessed. VDR genotypes (BsmI, Taq1 and FOK1) were investigated by polymerase chain reaction fragment length polymorphism. Results: There was a significant negative correlation between serum 25-OH D and FBG, TC, TG, and LDL-C levels, and a positive correlation with HDL-C levels in all diabetic patient groups. The risk of CAD was markedly higher in the group of T2DM with CAD in comparison to the control (p<0.0001) and the T2DM group. Regarding Taq1, there was also a significantly higher risk of CAD in Tt+tt genotypes and t allele in the T2DM with CAD group compared to control (p<0.001, 0.031 respectively). In addition, 25-OH D concentrations and the prevalence of VDR polymorphisms (BsmI, Taq1) were correlated with the risk of CAD. Conclusion: Deficiency of vitamin D and the prevalence of VDR polymorphisms (BsmI, Taq1) can serve as important markers for CAD.

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Vitamin D deficiency among Type 2 Diabetes patients in Saudi Arabia: a systematic review

Cited by 8 publications

References 27 publications

Relation of Hypoxia Inducible Factor, Dyslipidemia and CAD Saudi Patients With Type 2 Diabetes

Relation of Hypoxia Inducible Factor, Dyslipidemia and CAD Saudi Patients With Type 2 Diabetes

Association of lncRNA LINC01173 Expression with Vitamin-D and Vitamin B12 Level Among Type 2 Diabetes Patients

Association of Vitamin D Deficiency and Vitamin D Receptor Genetic Variants With Coronary Artery Disease in Type 2 Diabetic Saudi Patients

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