Vitamin D Deficiency: An Underestimated Factor in Sepsis?

Delrue, Charlotte; Speeckaert, Reinhart; Delanghe, Joris; Speeckaert, Marijn M.

doi:10.3390/ijms24032924

Cited by 18 publications

(16 citation statements)

References 84 publications

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“…[34] Sepsis, as a systemic inflammatory response syndrome, is closely related to vitamin D. The multiple functions of vitamin D in the immune system 's response to infection may make it an important part of the fight against sepsis. [31] The cause of sepsis is systemic organ dysfunction caused by the imbalance of immune response after the host is infected by pathogens, mainly manifested as enhanced systemic inflammatory response. [34,35] Immune dysfunction, mitochondrial dysfunction, coagulation issues, neuroendocrine-immune network issues, endoplasmic reticulum stress, and autophagy are all factors in the pathophysiology of sepsis.…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D receptor gene polymorphism with the risk of sepsis: A systematic review and meta-analysis

Li,

Chen

et al. 2023

Medicine

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Background: To investigate the association between sepsis and the vitamin D receptor (VDR) gene polymorphisms. Methods: Databases including PubMed, Cochrane Library, EMbase, CNKI, Wanfang Data, and VIP Data were systematically searched. The association was assessed using odds ratios (ORs), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.4. Results: We identified a total of 5 studies. The relationship between VDR gene polymorphisms (Apa I, Bsm I, Taq I, and Fok I), and incidence of sepsis was investigated. The results of this meta-analysis showed that the allelic contrast model (F vs f, P = .03, OR = 0.65, 95% CI = 0.44–0.95), dominant genetic model (FF vs Ff + ff, P = .02, OR = 0.53, 95% CI = 0.30–0.91), and codominance genetic model (FF vs ff, P = .03, OR = 0.39, 95% CI = 0.16–0.91) of VDR Fok I locus increased the risk of sepsis, and the lack of association between the VDR Fok I gene polymorphism and the risk assessment of sepsis, based on the ethnic subgroup analysis, might be attributable to the small sample size. The risk of sepsis with Apa I, Bsm I, and Taq I did not appear to be correlated. Conclusion subsections: This meta-analysis revealed that the VDR Fok I polymorphism is closely associated with the susceptibility to sepsis, and patients with sepsis have lower 25-hydroxyvitamin D levels. VDR Fok I gene mutations may change the risk of sepsis.

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Section: Discussionmentioning

confidence: 99%

Association of vitamin D receptor gene polymorphism with the risk of sepsis: A systematic review and meta-analysis

Li,

Chen

et al. 2023

Medicine

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“…A large and growing body of evidence supports a role for vitamin D in inflammation and modulation of immune function, and vitamin D deficiency has been associated with increased systemic levels of inflammatory markers such as interleukin‐6 (IL‐6) 108,109 . Vitamin D has been shown to inhibit production of numerous proinflammatory cytokines and increase production of anti‐inflammatory mediators in cells expressing the VDR, including many different immune cell populations 110 . Preclinical studies have demonstrated that vitamin D administration can reduce the occurrence or slow the progression of many different immune‐related diseases 73,111 .…”

Section: Keloids: More Than Just ‘Scars’mentioning

confidence: 99%

“…108,109 Vitamin D has been shown to inhibit production of numerous proinflammatory cytokines and increase production of anti-inflammatory mediators in cells expressing the VDR, including many different immune cell populations. 110 Preclinical studies have demonstrated that vitamin D administration can reduce the occurrence or slow the progression of many different immune-related diseases. 73,111 This is consistent with epidemiological evidence of associations between vitamin D deficiency and immune-related diseases and disorders, including type 1 diabetes, multiple sclerosis, psoriasis, rosacea, rheumatoid arthritis, respiratory infections, cardiovascular disease, systemic lupus erythematosus, inflammatory bowel disease and sepsis, in addition to keloid disorder.…”

Section: Vitamin D and Keloid Disorder: Possible Mechanismsmentioning

confidence: 99%

“…73,111 This is consistent with epidemiological evidence of associations between vitamin D deficiency and immune-related diseases and disorders, including type 1 diabetes, multiple sclerosis, psoriasis, rosacea, rheumatoid arthritis, respiratory infections, cardiovascular disease, systemic lupus erythematosus, inflammatory bowel disease and sepsis, in addition to keloid disorder. 60,73,89,91,108,110,[112][113][114] Given the widely accepted role of both local and systemic inflammation in keloid disorder, 4 it is reasonable to speculate that vitamin D deficiency may contribute to a proinflammatory state that is permissive to, or actively promotes, development of keloids.…”

Section: Vitamin D and Keloid Disorder: Possible Mechanismsmentioning

confidence: 99%

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A role for vitamin D and the vitamin D receptor in keloid disorder

Hahn

Combs

Powell

et al. 2023

Wound Repair Regeneration

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Keloids are disfiguring fibroproliferative lesions that can occur in susceptible individuals following any skin injury. They are extremely challenging to treat, with relatively low response rates to current therapies and high rates of recurrence after treatment. Although several distinct genetic loci have been associated with keloid formation in different populations, there has been no single causative gene yet identified and the molecular mechanisms guiding keloid development are incompletely understood. Further, although it is well known that keloids are more commonly observed in populations with dark skin pigmentation, the basis for increased keloid risk in skin of colour is not yet known. Because individuals with dark skin pigmentation are at higher risk for vitamin D deficiency, the role of vitamin D in keloid pathology has gained interest in the keloid research community. A limited number of studies have found lower serum vitamin D levels in patients with keloids, and reduced expression of the vitamin D receptor (VDR) in keloid lesions compared with uninjured skin. Vitamin D has documented anti‐inflammatory, anti‐proliferative and pro‐differentiation activities, suggesting it may have a therapeutic role in suppression of keloid fibrosis. Here we review the evidence supporting a role for vitamin D and VDR in keloid pathology.

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“…The role of Vitamin D in immune function is well reported with a growing evidence base linking low levels to poorer outcomes from infectious diseases [ 1 – 3 ]. Further, Vitamin D is vital for calcium homeostasis and skeletal health, with risk of rickets, osteomalacia and osteopaenia in insufficient or deficient states [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Vital D: A modifiable occupational risk factor of UK healthcare workers

Phelan,

Thangamuthu,

Muthumeenal

et al. 2024

PLoS ONE

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Background The role of Vitamin D in immune function is well reported with a growing evidence base linking low levels to poorer outcomes from infectious disease. Vitamin D deficiency and insufficiency are prevalent worldwide with healthcare workers identified as a known at-risk group. Here we aim to investigate serum Vitamin D levels in a UK population of front line healthcare workers and to promote the occupational risk. Methods A cross-sectional study of 639 volunteers was conducted to identify the prevalence of Vitamin D deficiency and insufficiency amongst a population of front-line health care workers in the UK. Participant demographics and co-morbid factors were collected at the time of serum sampling for multivariate analysis. Results Only 18.8% of the population had a normal vitamin D level greater than or equal to 75nmol/L. This is compared to Public Health England’s (PHE) stipulated normal levels of 60% during winter. 81.2% had a level less than 75nmol/L, with 51.2% less than 50nmol/L and 6.6% less than 25nmol/L. For serum levels less than 25nmol/L, Asian ethnicity was more likely to have a vitamin D deficiency than non-asian (OR (95%CI): 3.81 (1.73-8.39), p = 0.001), whereas white ethnicity was less likely to have a vitamin D deficiency compared to non-white (OR (95%CI: 0.43 (0.20-0.83), p = 0.03). Other factors that contributed to a higher likelihood of lower-than-normal levels within this population included male sex, decreased age and not taking supplementation. Conclusion It is concluded that our population of healthcare workers have higher rates of abnormal vitamin D levels in comparison with the general UK population reported prevalence. Furthermore, Asian ethnicity and age 30 years and below are more at risk of vitamin D insufficiency and deficiency. This highlights an occupational risk factor for the healthcare community to consider.

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Vitamin D Deficiency: An Underestimated Factor in Sepsis?

Cited by 18 publications

References 84 publications

Association of vitamin D receptor gene polymorphism with the risk of sepsis: A systematic review and meta-analysis

Association of vitamin D receptor gene polymorphism with the risk of sepsis: A systematic review and meta-analysis

A role for vitamin D and the vitamin D receptor in keloid disorder

Vital D: A modifiable occupational risk factor of UK healthcare workers

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