Vitamin D Deficiency and Association With Body Mass Index and Lipid Levels in Hispanic American Adolescents

Kumaratne, Mohan; Early, Gayle J.; Cisneros, Jasmine

doi:10.1177/2333794x17744141

Cited by 33 publications

(34 citation statements)

References 20 publications

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“…Their results presented that overweight and obese adolescents comprised 55.6% of the study sample and 33.9% of them were vitamin D deficient. The overweight or obese subjects in this sample were twice as likely to be vitamin D deficient as the underweight or healthy weight subjects [35]. This may be interpreted in the context of the fact that vitamin D insufficiency and excessive fat accumulation have mutually negative effects (i.e., the adipose tissue has an influence on the metabolism of vitamin D on the one hand, and its pathogenic role in the obesity development mechanisms on the other hand).…”

Section: Discussionmentioning

confidence: 83%

Effect of Vitamin D Supplementation on Glycemic Control in Children with Type 1 Diabetes Mellitus: A Randomized Clinical Trial

El-Sayed¹,

Raaouf²,

Laimon³

2019

AJNR

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Background: Vitamin D endocrine system is a potential immune system modulator and has been implicated in the pathogenesis of several autoimmune diseases including type 1 diabetes mellitus. A relationship between type 1 diabetes and vitamin D deficiency has been reported, in which low vitamin D levels are shown to have a negative effect on beta-cell function. The aims of the study were to investigate vitamin D status and to evaluate the effect of vitamin D3 supplementation on glycemic control in children with type 1 diabetes. Method: A randomized clinical trial including 80 children who were newly diagnosed with type 1 diabetes and randomly assigned into either control or intervention arm was used. Vitamin D status and Glycohemoglobin (HbA1c) were assessed initially for both the study two arms. Diabetic children of the intervention arm who had vitamin D deficiency and insufficiency were treated with 4000 units of vitamin D3 and calcium (500 mg/day) in oral liquid form. After the study interference (3 months later), HbA1C was measured again for both arms as an indicator for glycemic control. Differences in mean±SD HbA1C and body mass index were assessed before and after the study. Results: The mean of body mass index in intervention arm was 14.77±3.49, while in control arm was 17.84±3.87, with statistically significant deference between two arms P<.001. Furthermore, the mean change in HbA1c levels in intervention arm was 6.78±1.94 compared with 7.03±1.83 in control arm, with no statistically significant deference detected between children of the study two arms P<.460. Conclusion: Vitamin D3 supplement on the clinical base improves glycemic control in pediatrics with type I diabetes mellitus and vitamin D deficiency.

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Section: Discussionmentioning

confidence: 83%

Effect of Vitamin D Supplementation on Glycemic Control in Children with Type 1 Diabetes Mellitus: A Randomized Clinical Trial

El-Sayed¹,

Raaouf²,

Laimon³

2019

AJNR

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“…A negative correlation between vitamin D level and body mass index (BMI) has been described in literature (O'Dell et al, 2002;Rovner et O'Brien, 2008;Anonymous, 2014;Bani-issa et al, 2017;Elizondo-Montemayor et al, 2017;Hajjaj-Hassoun et al, 2017;Kumaratne et al, 2017). For example, Bani-issa et al (2017) found that in patients with BMI of 30 kg/m 2 or more, there was a risk of more than five times for vitamin D deficiency than for patients with BMI below 25 kg/m 2 .…”

Section: Discussionmentioning

confidence: 99%

Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients

Laizāne

Saulīte

Feierābende

et al. 2019

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Vitamin D deficiency is common and widespread globally. Vitamin D has an immunomodulatory effect, but it is still unclear whether its deficiency is associated with higher disease activity. The aim of this retrospective study was to determine the serum concentration of vitamin D in children with paediatric arthritis (juvenile idiopathic arthritis and reactive arthritis). Prevalence of hypo-vitaminosis D among 98 children with juvenile idiopathic arthritis and reactive arthritis was determined and association between serum concentration of vitamin D and disease activity markers was found. Prevalence of vitamin D deficiency among children included in this study was 69.07%. Children with juvenile idiopathic arthritis had a significantly lower vitamin D level than children with reactive arthritis. There was a statistically significant moderate negative correlation between serum concentration of vitamin D and patient age, as well as a weak negative correlation between vitamin D level and patient body mass index. The significant correlations found between vitamin D level and inflammatory markers indicate that further research on the role of vitamin D in disease activity is needed.

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“…Several studies have revealed that patients with SCD are at risk of multiple macro-and micronutritional deficiencies, and they have a higher prevalence and risk of VDD regardless of their age or ethnic background [10][11][12]. Several studies have explored the risk factors influencing vitamin D status, such as limitation of exposure to natural light, which affects vitamin D biosynthesis; dark skin, which acts as a natural barrier to UV irradiation penetrating the skin; obesity and high body mass index, in which adipose tissues sequester vitamin D; and poor dietary intake of vitamin D [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A Meta-analysis on Vitamin D Deficiency in Patients with Sickle Cell Disease

Mohamed¹,

MohamedElmugadam²,

Awadalla³

et al. 2020

DSAHMJ

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Vitamin D Deficiency (VDD) is reported to be more frequent with serious clinical outcomes in patients with Sickle Cell Disease (SCD). There is a wide disparity in data in the existing literature regarding the prevalence and risk of VDD in patients with SCD. These data require further summary and analyses for better accuracy. This review aimed to assess the association between VDD and SCD, and was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Medline/ PubMed, World Health Organization Virtual Health Library, ScienceDirect, and Google Scholar were used for the systematic search. A random effects model was used to estimate the pooled prevalence, Risk Ratio (RR), and Standardized Mean Difference (SMD) estimates with the corresponding 95% Confidence Interval (CI) using OpenMeta Analyst software version 10.10 (Tufts Medical Center, Boston, MA, USA). Twenty-five studies fulfilled the eligibility criteria. The prevalence of VDD among patients with SCD was 63.8% (95% CI, 52.5-75.1). The risk of VDD among patients with SCD was more than two times that of the general population (RR = 2.129; 95% CI, 1.024-4.423; p < 0.001). Serum vitamin D levels were significantly lower in SCD patients than in their controls (SMD = −1.883: 95% CI, −3.006 to −0.760; p < 0.001). This review provides a comprehensive view of the association between vitamin D status and SCD.

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Vitamin D Deficiency and Association With Body Mass Index and Lipid Levels in Hispanic American Adolescents

Cited by 33 publications

References 20 publications

Effect of Vitamin D Supplementation on Glycemic Control in Children with Type 1 Diabetes Mellitus: A Randomized Clinical Trial

Effect of Vitamin D Supplementation on Glycemic Control in Children with Type 1 Diabetes Mellitus: A Randomized Clinical Trial

Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients

A Meta-analysis on Vitamin D Deficiency in Patients with Sickle Cell Disease

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