Vitamin D Deficiency and Its Relation to Allergic Diseases: A Cross Sectional Study Among Allergic Patients from Jeddah City, Saudi Arabia

Abbas, Amal; Wajeeh, Johara; Wajeeh, Hanan; Alghamdi, A I; Sharief, Shahd Al

doi:10.46889/jcim.2020.1106

Cited by 1 publication

(2 citation statements)

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“…This finding comes along with the previous scientific evidence showing that an adequate concentration of vitamin D in the blood can help suppress B-cell hyperactivity and lower the number of released Igs that can trigger an allergic reaction (i.e., IgE and cytokines) [ 40 , 41 ]. These findings were also observed in Abbas et al’s recent study performed in the city of Jeddah; it was shown that the majority of allergic patients with an elevated serum level of IgE appeared to have deficient vitamin D concentrations in their blood [ 42 ].…”

Section: Discussionsupporting

confidence: 70%

“…Other opinions indicated that early sensitization to food in infancy could develop into inhalant allergies as the child grows older [ 54 ]. In addition, Jeddah’s year-round warm and humid temperature could potentially provide an ideal habitat for a high concentration of the dust mite allergen in homes, provoking respiratory allergies [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Risk Factors for IgE and IgG Cow's Milk Protein Allergies in Saudi Arabia

Baghlaf,

Eid,

Enani

et al. 2023

Cureus

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Cow's milk protein allergies (CMPAs) particularly occur in infancy and early childhood due to an immunological allergic reaction to milk proteins. This issue is increasing in Saudi Arabia and requires research to improve health status and provide alternatives. Our study aims to investigate the important aspects of immunoglobulin E (IgE) and IgG CMPA in Saudi Arabia regarding its prevalence and association with demographic and health-related factors in both adult and pediatric populations. A descriptive retrospective cross-sectional study was conducted on 376 patients, comprising 314 adults aged between 19 and 86 years, and 62 pediatric patients aged between one and 12 years. The study focused on individuals who attended a private medical center in Jeddah city over the past five years. Laboratory results for food allergy of IgE and IgG tests, including cow's milk proteins (CMPs), serum 25-hydroxyvitamin D (25OHD), specific IgE inhalant allergy results, and other health-related factors were collected from an electronic record system. Results have shown that casein was the most common sensitizing allergen of CMPs in adults, whereas α-lactalbumin was the most common sensitizing allergen in pediatrics. The most frequent sensitizing allergen in IgG CMP was cow's milk in 54/92 (58.7%) adults, followed by cow's sour milk products 41 (44.6%). Cow's milk was the most common sensitizing allergen in 20/20 (100%) children. The rate of CMPA was significantly higher in children younger than five years old ( P =0.003), while children who interacted with pets had a marginal significantly reduced rate ( P = 0.054). Thus, cow's milk is the most sensitizing allergen in IgG CMPs in adults and pediatrics.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%