Vitamin D deficiency and length of pediatric intensive care unit stay: a prospective observational study

Sankar, Jhuma; Lotha, W.; Ismail, Javed; Anubhuti, C.; Meena, Rameshwar S.; Sankar, Mari Jeeva

doi:10.1186/s13613-015-0102-8

Cited by 40 publications

(61 citation statements)

References 29 publications

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“…In total, 23 patients in the VD group received anti-fungal treatment, which was markedly lower than the 42 patients from the placebo group (P = 0.02). .3) days] (P = 0.03), whereas cases of patient death were similar between the two groups (P = 0.22), which is consistent with previous studies reporting that vitamin D is not correlated with a higher prediction of risk mortality scores (18) but is with the duration of PICU stay (22) . Moreover, the length of central catheters was also significantly shorter in the VD group [3.1 (1.0) days] than the placebo group [4.3 (1.5) days] (P = 0.04).…”

Section: Resultssupporting

confidence: 89%

“…A low serum vitamin D level is also associated with higher incidence of lower tract acute respiratory infections (20) , the need for mechanical ventilation, increased vasopressor use and a lower serum calcium level in PICU (21) . In addition, it was reported that VDD children, with serum level of vitamin D metabolite 25-hydroxyvitamin D (25OHD) <20 ng mL À1 , had a longer duration of PICU stay than others (22) . Of particular interest to the present study, a recent in vitro antimicrobial screening study indicated that vitamin D exerted fungicidal functions against Candida albicans (23) .…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D‐supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo‐controlled clinical trial

Xie

Zhu

et al. 2019

J Human Nutrition Diet

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Background The prevalence of Candida infections in paediatric intensive care units (PICUs) has dramatically increased as a result of resistance to conventional anti‐fungal treatments. Because vitamin D has been shown to exhibit fungicidal activity against Candida infection in an in vitro antimicrobial screening, we aimed to investigate the effect of vitamin D on Candida infections in the PICU. Methods Four hundred sixteen eligible children aged between 12 months to 5 years old admitted to the PICU, who were on broad‐spectrum antibiotic therapy, participated in the study. Patients were randomly assigned to two study groups, receiving a plain yogurt drink (placebo group) or supplemented with 300 IU day−1 vitamin D (VD group). Primary outcome was defined as the incidences of Candida colonisation (Candida isolated from rectal swab) 14 days after enrollment. Secondary outcome measures were Candida growth in blood (candidaemia) and urine (candiduria). Results The prevalence of candiduria as well as candidaemia was significantly lower in the VD‐treated group (26 cases) than in the placebo group (62 cases). The mean (SD) length of PICU stay was obviously lowered in the VD group [11.8 (1.2) days] compared to the placebo group [15.2 (2.3 days)], whereas cases of patient death were similar between the two groups. Conclusions Supplementation of vitamin D effectively reduces infections of Candida in children who were critically ill and on broad‐spectrum antibiotic treatment.

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Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Vitamin D‐supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo‐controlled clinical trial

Xie

Zhu

et al. 2019

J Human Nutrition Diet

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“…There was no statistically significant difference between vitamin D level and PIM2 score. In accordance to our result, Sankar et al (24) and Rey et al (19) reported no significant relation between them. There was no statistically significant difference between vitamin D level on admission and length of PICU stay.…”

Section: Discussionsupporting

confidence: 82%

“…(23) In this context, we found that vitamin D levels were negatively correlated to PELOD score. Also, Sankar et al (24) observed that children who were vitamin D deficient at admission were more likely to have higher organ dysfunction scores, although the differences were not statistically significant. There was no statistically significant difference between vitamin D level and PIM2 score.…”

Section: Discussionmentioning

confidence: 99%

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Study of Serum Vitamin D Level among Critically Ill Patients Admitted to Alexandria University Pediatric Intensive Care Unit

Halwany¹

2017

jmscr

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Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

et al. 2020

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Objectives: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction.Design: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those The Society of Critical Care Medicine guidelines are intended for general information only, are not medical advice, and do not replace professional advice, which should be sought for any medical condition. The full disclaimer for guidelines can be accessed at https ://www.sccm.org/Resea rch/Guide lines /Guide lines . panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. Methods:The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, "in our practice" statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate. Results:The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 49 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these, "in our practice" statements were provided. In addition, 52 research priorities were identified. Conclusions:A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research. S14 the group heads, panel members, and methodologists. Searches utilized ...

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Vitamin D deficiency and length of pediatric intensive care unit stay: a prospective observational study

Cited by 40 publications

References 29 publications

Vitamin D‐supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo‐controlled clinical trial

Vitamin D‐supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo‐controlled clinical trial

Study of Serum Vitamin D Level among Critically Ill Patients Admitted to Alexandria University Pediatric Intensive Care Unit

Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

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