Vitamin D deficiency and low bone mineral density in native Chinese rheumatoid arthritis patients

Abstract

The incidences of osteoporosis and osteopenia were higher in RA patients compared to the age- and gender-matched healthy controls. Low serum 25OHD levels correlate with low BMD and high disease activity in RA patients.

Vitamin D in rheumatoid arthritis—towards clinical application

“…In addition to conventional RA disease activity and functional outcome scores, some studies have reported inverse correlations between serum 25(OH)D and circulating inflammatory markers. 14 Direct correlation between serum 25(OH)D concentrations and RA-associated systemic bone loss has also been reported in some studies, 14,104 whereas in others no association between serum 25(OH)D and focal bone erosion was observed. 105 Although these data suggest that low vitamin D status, in this case low levels of serum 25(OH)D, is associated with RA disease progression, inferring causality is difficult because disease severity can also restrict patient mobility, limit access to UV light and thus diminish conventional epidermal synthesis of parental vitamin D. Some cross-sectional analyses have shown a strong inverse association between serum 25(OH)D concentrations and disease activity in patients with RA, suggesting that disease severity can contribute to low vitamin D status in these patients.…”

Relationship between Serum 25-Hydroxyvitamin D Levels, Disease Activity and Anti-Cyclic Citrullinated Peptide Antibody Levels in Indian Rheumatoid Arthritis Patients

“…In a study of 158 RA patients, Moghimi, et al [26], found an inverse relationship between DAS and 25-OH vitamin D levels. Also, Zakeri, et al [27] and Chen, et al [28] showed that 25-OH vitamin D deficiency is linked with the activity levels in RA. The study by Patel, et al also observed a strong inverse correlation between serum 25-OH vitamin D level and DAS score at disease onset It is seen that RA patients with high disease activity have lower 25-OH vitamin D levels as those with low activity score [24].…”

Effects of 25‐hydroxyvitamin D and vitamin D‐binding protein on bone mineral density and disease activity in Malaysian patients with rheumatoid arthritis

“…The same meta‐analysis found a negative association between 25(OH)D levels and disease activity levels, but the results from Asian studies are not so clear‐cut. Three studies, two from China and one from India showed an inverse association between 25(OH)D levels and Disease Activity Score of 28 joints (DAS28), but two other studies, one each from Japan and Thailand did not show such an association.…”