2017
DOI: 10.1089/aid.2016.0144
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Vitamin D Deficiency and Metabolism in HIV-Infected and HIV-Uninfected Men in the Multicenter AIDS Cohort Study

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Cited by 14 publications
(17 citation statements)
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“…Vitamin D levels, 25(OH)D and 1,25(OH) 2 D, were measured in an ancillary study that evaluates the impact of HAART initiation on vitamin D metabolism 16 and available in 640 HIV-infected participants following HAART initiation. The visit at which vitamin D levels were measured occurred between 1997 and 2013 and was used as the baseline visit.…”
Section: Study Populationmentioning
confidence: 99%
“…Vitamin D levels, 25(OH)D and 1,25(OH) 2 D, were measured in an ancillary study that evaluates the impact of HAART initiation on vitamin D metabolism 16 and available in 640 HIV-infected participants following HAART initiation. The visit at which vitamin D levels were measured occurred between 1997 and 2013 and was used as the baseline visit.…”
Section: Study Populationmentioning
confidence: 99%
“…A prior study of 54 HIV-infected patients and 20 controls found lower levels of 1,25(OH) 2 D to be associated with HIV-infection but not with CD4 count, but 27 patients met criteria for AIDS, which may represent a different population and immune context [35]. Prior reports from the MACS vitamin D substudy found no difference in median 1,25[OH] 2 D level by HIV serostatus (median 45.0 pg/mL in HIV-infected and 45.1 pg/mL in HIV-uninfected [27]). It must be emphasized that the reliability of 1,25(OH) 2 D was modest (ρ=0.34 between repeated measures) and levels are known to be transient.…”
Section: Discussionmentioning
confidence: 99%
“…For the present study, we included men with pre- or post-HAART vitamin D metabolite measurements from the MACS vitamin D substudy [27], who had at least one post-HAART CD4 measurement and evidence of viral suppression (defined as at least one HIV RNA measurement <500 copies/ml within 2 years of starting HAART) following HAART initiation. Included men were followed from HAART initiation (defined as the midpoint between last observed time not on HAART to first observed time on HAART) until viral failure (defined as HIV RNA measurement >500 copies/ml 2 years or more after starting HAART) or last CD4 measurement.…”
Section: Methods and Methodsmentioning
confidence: 99%
“…Covariates for inclusion in the analysis were drawn from prior work in the MACS evaluating correlates of vitamin D metabolite levels. 16 Covariate values were assessed at the time point of the vitamin D metabolite measurements. Enzymelinked immunosorbent assays along with confirmatory Western blot determined HIV status (HIV infected vs. HIV uninfected).…”
Section: Covariatesmentioning
confidence: 99%
“…We selected covariates into the final model based on literature 21 and previous study results. 16 Final models were adjusted for age >50 years, BMI, and HCV infection and were run stratified by HIV status.…”
Section: Statistical Analysesmentioning
confidence: 99%