Vitamin D deficiency and placental calcification in low-risk obstetric population: are they related?

Fındık, Rahime Bedir; Ersoy, Ali Özgür; Fidanci, Vildan; Taşçı, Yasemin; Helvacıoğlu, Yeksin; Karakaya, Jale

doi:10.3109/14767058.2015.1118043

Cited by 4 publications

(7 citation statements)

References 19 publications

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“…Despite the findings of Chen et al (6), the present study did not evaluate the maternal age and its correlation with PCs. Smoking, maternal age, and parity are reported as the major predisposing factors of PC (7).…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Placental Calcification and Estimated Fetal Weight Percentile at 30-34 Weeks of Pregnancy

Barati

Masihi

Barahimi

et al. 2019

International Journal of Women’s Health and Reproduction Scienc

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Objectives: The identification of at-risk fetus is considered as one of the most difficult challenges for clinicians and researchers although the clinical significance of placental calcifications (PCs) and its relation to adverse pregnancy outcome are controversial. Therefore, the present study aimed to evaluate the relationship between PC and estimated fetal weight (EFW) percentile at 30-34 weeks of pregnancy. Materials and Methods: This prospective cross-sectional study was carried out on all pregnant women except for multiple pregnancy subjects who were admitted to an outpatient perinatal center from October 2016 to September 2018. Several parameters were measured at 30-34 weeks of pregnancy, including EFW, umbilical artery pulsatility index (PI), middle cerebral artery PI, cerebroplacental ratio (CPR), right and left uterine artery PI, along with right and left uterine artery notch. Finally, the calcification of the placenta with any shape and degree was determined as well. Results: In this study, 739 pregnant women were evaluated for PC, including patients with PC (9.87%), small-for-gestational age (SGA, 3.65%), and those with at least one abnormal Doppler index (23.95%). Patients with PC and those with at least one abnormal Doppler index had significantly higher SGA (29.62% and 12.42%, respectively). In addition, there were 55.55% and 30.13% patients with SGA and PC in the group with at least one abnormality in terms of Doppler indices. Conclusions: In general, the findings showed that PC is more common in SGA. Based on the results, at least one abnormality in Doppler indices was more common in PC and SGA, and uterine artery Doppler abnormality was the most prevalent abnormal findings in the arterial Doppler. Thus, PC may be an important marker for adverse pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

“…This echogenic focusing is also associated with adverse maternal and fetal outcomes and may be present as a pathological event caused by a wide range of environmental factors (6). The most common PC predisposing factors are smoking, parity, and maternal age (7). The prevalence of PPC widely ranges from 3.8% to 23.7% (6).…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Placental Calcification and Estimated Fetal Weight Percentile at 30-34 Weeks of Pregnancy

Barati

Masihi

Barahimi

et al. 2019

International Journal of Women’s Health and Reproduction Scienc

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Section: Immunologymentioning

confidence: 99%

“…In fact, cytokeratin-18 is the main protein filament in the liver and is cleaved during apoptosis by caspases [70]. This M30 antibody is found to be significantly higher in both maternal and umbilical cord serum signifying liver damage [70]. The increased levels of many apoptotic proteins signify that cell death is occurring more rapidly and at multiple sites in patients with ICP; a well-designed treatment is needed to restore the immune system for these patients.…”

Section: Immunologymentioning

confidence: 99%

Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy

Larson

Kovilam

Agrawal

2015

Expert Review of Clinical Immunology

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Summary Intrahepatic cholestasis of pregnancy poses a great risk to both maternal and fetal health. Despite extensive research, much of the pathogenesis of this disorder is unknown. The increase in bile acids observed in patients with intrahepatic cholestasis of pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. In this literature review, we have critically reviewed the current literature regarding the changes in the immune system and the potential effects of immunological changes in the management of the patient. The current treatment, ursodeoxycholic acid, is also discussed along with potential combination therapies and future directions for research.

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“…In the second trimester, premature uterine contraction in women may be related to the homeostasis of calcium-phosphorusmagnesium (8). Maternal calcium and vitamin 25 (OH) D levels were found to be associated with PC and it was concluded that the placenta is important in vitamin D regulation (9,10).…”

Section: Introductionmentioning

confidence: 99%

Preterm placental calcification: maternal calcium, magnesium, 25(OH)D levels and adverse obstetric outcomes in low-risk pregnant women

GENÇ

ÖZKAN

KÜKRER

et al. 2022

Journal of Health Sciences and Medicine

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Aim:The aim of our study is to examine early and late preterm placental calcification (PPC) and compare their relationship with maternal calcium, magnesium and 25(OH) D levels and adverse obstetric outcomes. Material and Method:This prospective cohort study was conducted by examining the pregnant women at their 24th to 36th gestational weeks who applied to the Gynecology Department of Okmeydani Training and Research Hospital. In this study, 207 patients were selected as the study group.Results: When the early and late PPC groups were compared, rates of low birth weight (LBW) was statistically higher in the early PPC group. (p=0.022) Oligohydramnios was more common in the early and late PPC patients compared to non-PPC pregnant women. However, oligohydramnios and LBW were not found statistically significant difference in logistic regression analysis. There was also no statistically significant difference in maternal calcium, magnesium and vitamin D levels between the groups. Conclusion:Preterm placental calcifications might be associated with fetal and maternal complications. But the diagnosis of PPC alone is not effective in determining fetal prognosis.

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Vitamin D deficiency and placental calcification in low-risk obstetric population: are they related?

Abstract: Higher maternal calcium and lower 25(OH)D levels detected in patients with Grade 3 placental calcification indicated the importance of placenta on vitamin D regulation.

Cited by 4 publications

References 19 publications

Relationship Between Placental Calcification and Estimated Fetal Weight Percentile at 30-34 Weeks of Pregnancy

Relationship Between Placental Calcification and Estimated Fetal Weight Percentile at 30-34 Weeks of Pregnancy

Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy

Preterm placental calcification: maternal calcium, magnesium, 25(OH)D levels and adverse obstetric outcomes in low-risk pregnant women

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