Vitamin D deficiency and thyroid autoantibody fluctuations in patients with Graves’ disease – A mere coincidence or a real relationship?

Płazińska, Maria Teresa; Czarnywojtek, Agata; Sawicka‐Gutaj, Nadia; Zgorzalewicz-Stachowiak, Małgorzata; Czarnocka, Barbara; Gut, Paweł; Karlińska, Maria; Fichna, Marta; Stachowski, A; Ruchała, Marek; Krela‐Kaźmierczak, Iwona; Królicki, Leszek

doi:10.1016/j.advms.2019.11.001

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…It is worth mentioning that the positive effect on thyroid function and the related economic benefits were confirmed by the study of Mirhosseini et al on a group of 11,017 participants who were supplemented with vitamin D to obtain its physiological concentration [33]. Researchers from the Medical University of Warsaw came to very similar conclusion; after analyzing the results of 269 cases (with an additional criterion for dividing into smokers and non-smokers) they showed that non-smoking patients with GD receiving vitamine D were more likely to achieve immunological remission than those without vitamine D supplementation, especially smokers [34]. However, these results, are not unequivocal, and many publications do not confirm the occurrence of the above correlations.…”

Section: Human Studiesmentioning

confidence: 88%

The correlation between vitamin D and autoimmune thyroid function – short review

Piekarska

Maksymowicz

Kasperski

et al. 2021

J Educ Health Sport

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Vitamin D is traditionally associated with the regulation of mineral metabolism and bone homeostasis, and its deficiency is the cause of diseases such as osteoporosis or osteomalacia. However, numerous studies in recent years suggest that thanks to the common expression of the vitamin D receptor (VDR) on the cells of the body and the related additional anti-inflammatory, immunomodulating, antioxidant, anti-fibrotic vitamin D effects, it may play a role in the development and progress of autoimmune diseases and tumors. The collected data suggest that low vitamin D levels correlate with the occurrence of autoimmune diseases of the thyroid gland and that there is a significant correlation between 25(OH)D and anti-TPO or anti-Tg levels. However, these data are inconclusive and further research is needed to confirm this relationship and determine whether lowered vitamin D titer is the cause or rather the consequence of autoimmune thyroid disorders, and whether vitamin D supplementation could prove to be an effective prophylaxis and treatment.

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Section: Human Studiesmentioning

confidence: 88%

The correlation between vitamin D and autoimmune thyroid function – short review

Piekarska

Maksymowicz

Kasperski

et al. 2021

J Educ Health Sport

View full text Add to dashboard Cite

show abstract

“…Two meta-analyses suggested that a low vitamin D status may increase the risk of GD ( Wang et al, 2015 ; Xu et al, 2015 ). Moreover, there is data on the association between low vitamin D levels and the thyroid autoantibody titre in patients with Graves’ disease as well as the association of polymorphisms in the vitamin D receptor (VDR) gene in patients with GD ( Unal et al, 2014 ; Zhang et al, 2015 ; Veneti et al, 2019 ; Płazińska et al, 2020 ).…”

Section: Vitamin D and Thyroid Pathophysiologymentioning

confidence: 99%

Vitamin D, Thyroid Hormones and Cardiovascular Risk: Exploring the Components of This Novel Disease Triangle

et al. 2021

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The role of thyroid hormones (THs) in the cardiovascular (CV) system, through several direct and indirect effects is recognized. Even very small modification in TH levels (as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome) may adversely affect the CV system, whereas thyroid hormones benefit the CV system and improve the prognosis. There is also evidence of vitamin D effects on cardiometabolic disease (e.g., through modulation of endothelial and smooth muscle cell activity, renin-angiotensin-aldosterone system, nitric oxide, oxidative stress, and inflammatory response), as well as an association between vitamin D [25(OH)D] deficiency and autoimmune thyroid diseases or cancer, and a relationship between vitamin D concentration and titers of antibodies and thyroid autoimmunity replacement. Interestingly, experimental data indicate a direct effect of vitamin D on Type 2 deiodinase expression causing subsequential peripheral conversion of T4 into T3. However, the functional links among THs, vitamin D and the cardiovascular system, and clinical effects of coexisting abnormalities in this new troublesome triad, have not yet been reviewed. The main aim of this review is to discuss pathophysiology of this relationship, proposing new mechanistic insights involving vitamin D in the modulation of cardiometabolic disease and thyroid profile.

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“…Its role is known to be far beyond the earlier perception, as vitamin D serves as an immune system regulator and alters cell differentiation and proliferation [ 7 ]. Therefore, vitamin D seems to be an excellent candidate as an environmental contributor to various autoimmune, inflammatory, and neoplastic diseases [ 8 , 9 ]. An inverse relationship between vitamin D concentration and cancer risk has been confirmed in the case of colon, breast, prostate, gastric, and other cancer types [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D-Related Genes and Thyroid Cancer—A Systematic Review

Maciejewski

Łącka

2022

IJMS

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Vitamin D, formerly known for its role in calcium-phosphorus homeostasis, was shown to exert a broad influence on immunity and on differentiation and proliferation processes in the last few years. In the field of endocrinology, there is proof of the potential role of vitamin D and vitamin D-related genes in the pathogenesis of thyroid cancer—the most prevalent endocrine malignancy. Therefore, the study aimed to systematically review the publications on the association between vitamin D-related gene variants (polymorphisms, mutations, etc.) and thyroid cancer. PubMed, EMBASE, Scopus, and Web of Science electronic databases were searched for relevant studies. A total of ten studies were found that met the inclusion criteria. Six vitamin D-related genes were analyzed (VDR—vitamin D receptor, CYP2R1—cytochrome P450 family 2 subfamily R member 1, CYP24A1—cytochrome P450 family 24 subfamily A member 1, CYP27B1—cytochrome P450 family 27 subfamily B member 1, DHCR7—7-dehydrocholesterol reductase and CUBN—cubilin). Moreover, a meta-analysis was conducted to summarize the data from the studies on VDR polymorphisms (rs2228570/FokI, rs1544410/BsmI, rs7975232/ApaI and rs731236/TaqI). Some associations between thyroid cancer risk (VDR, CYP24A1, DHCR7) or the clinical course of the disease (VDR) and vitamin D-related gene polymorphisms were described in the literature. However, these results seem inconclusive and need validation. A meta-analysis of the five studies of common VDR polymorphisms did not confirm their association with increased susceptibility to differentiated thyroid cancer. Further efforts are necessary to improve our understanding of thyroid cancer pathogenesis and implement targeted therapies for refractory cases.

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Vitamin D deficiency and thyroid autoantibody fluctuations in patients with Graves’ disease – A mere coincidence or a real relationship?

Cited by 6 publications

References 34 publications

The correlation between vitamin D and autoimmune thyroid function – short review

The correlation between vitamin D and autoimmune thyroid function – short review

Vitamin D, Thyroid Hormones and Cardiovascular Risk: Exploring the Components of This Novel Disease Triangle

Vitamin D-Related Genes and Thyroid Cancer—A Systematic Review

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