Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis

Haan, Kim de; Groeneveld, A. B. J.; Geus, Hilde R. H. de; Egal, Mohamud; Struijs, Ard

doi:10.1186/s13054-014-0660-4

Cited by 239 publications

(205 citation statements)

References 42 publications

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“…Additionally, it was also documented that a relationship between vitamin D deficiency and increased mortality in community-acquired pneumonia (CAP) and sepsis was found [13][14][15][16]. Despite the increasing number of studies about CAP, there are scarce data about VAP, and to our knowledge, there are no studies related to the effects of vitamin D on specific pathogens such as XDR A. baumanii in the literature.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D level is associated with mortality predictors in ventilator-associated pneumonia caused by Acinetobacter baumannii

Haliloğlu

Bilgili

Haliloğlu

et al. 2016

J Infect Dev Ctries

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Introduction: Vitamin D plays a role in host defense and is known to be associated with mortality in patients in the intensive care unit (ICU). We aimed to evaluate the relationships between vitamin D levels and predictors of mortality in patients with ventilator-associated pneumonia (VAP) caused by extensively drug-resistant Acinetobacter baumanii (XDR A. baumanii). Results: Forty-for patients were studied over six months. All patients had vitamin D deficiency. The 28-day mortality in patients with 25(OH)D levels ≤ 10 ng/mL was higher than in patients with 25(OH)D > 10ng/mL (p = 0.001). The fourth-and seventh-day SOFA scores (p= 0.04 and p= 0.001) and first-and fourth-day procalcitonin levels (p = 0.03 and p = 0.004) were higher in patients with 25(OH)D levels ≤ 10 ng/mL. The clinical scores (SOFA, CPIS, and CEPPIS) and biomarkers (NT-proBNP, PCT) were negatively correlated with 25(OH)D levels in all study groups. Conclusions: Severe vitamin D deficiency was associated with adverse outcome in VAP due to XDR A. baumanii. Vitamin D levels may be a prognostic predictor of VAP. It is also important to evaluate the effect of rapid vitamin D replacement on mortality.

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Section: Introductionmentioning

confidence: 99%

Vitamin D level is associated with mortality predictors in ventilator-associated pneumonia caused by Acinetobacter baumannii

Haliloğlu

Bilgili

Haliloğlu

et al. 2016

J Infect Dev Ctries

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“…53 VDD <50 nmol/L represents a serious risk factor for infection, sepsis, and mortality in critically ill patients, as it increases susceptibility for severe infections and mortality. 54 This link between VDD and inflammatory biomarkers is also found in patients with multiple sclerosis, rheumatoid arthritis, and advanced age. 55 An interesting link among vitamin D, immunity, insulin resistance, and CVD was revealed in laboratory mice when researchers genetically eliminated macrophage VDRs and the mice developed arterial atherosclerotic plaques and insulin resistance due to hepatic and vascular inflammation.…”

Section: Increased Risk and Poor Outcomes For Ischemic Strokementioning

confidence: 89%

Vitamin D: Way More Important in Critical Care Than We May Have Recognized

Alspach¹

2017

Critical Care Nurse

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“…Depending to that analysis, it was reported that severe infection and mortality rates were high in vitamin D deficiency. In that analysis, risk for nosocomial infection development and intubation status were not evaluated (26).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Initial cortisol levels and Vitamin D on Mortality and Hospital Infection Development in Geriatric Patients at Intensive Care Unit

Kutlucan¹,

Kutlucan²

2016

Acta Med Anatol

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Introduction: Vitamin D deficiency is a common problem throughout the world. Also vitamin D deficiency has been reported in up to 82% of patients in intensive care unit (ICU). In addition, corticosteroid insufficiency is a common problem in ICU patients. In this study, we investigated the effects of initial cortisol and vitamin D levels on mortality, hospital infection development and intubation status in geriatric ICU patients. Methods:This study was conducted in a tertiary ICU. In a one-year period, 117 consecutive ICU patients older than 65 years of age were evaluated retrospectively. Looking at the first with Vitamin D and cortisol levels of the patients were collected in the first 24 hours of hospitalization. At follow up period, relationship between these data's and mortality, hospital infection, and intubation conditions were evaluated.Results: Initial Vitamin D, the morning cortisol, and albumin levels were found to be significantly lower (respectively; p <0.001, p <0.001 and p <0.001), and lactate levels were found to be significantly higher (p <0.001) in patients who died in ICU than alive patients. Development rate of hospital-acquired infection was found to be significantly higher (p = 0.025) in patients with low vitamin D levels than alive patients. Vitamin D and cortisol levels were found to be lower and lactate levels were found to be higher (respectively: p <0.001, p = 0.004, p = 0.035) in intubated patients than alive patients. Conclusion:In geriatric patients, relationship between initial vitamin D and cortisol levels and mortality, hospital infection and intubation conditions were evaluated in our study for the first time. The low level of vitamin D is seen as an important risk factor for the mortality, development of hospital-acquired infections and intubation. Also it is determined that the low cortisol creates a negative situation in terms of mortality and intubation.

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Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis

Cited by 239 publications

References 42 publications

Vitamin D level is associated with mortality predictors in ventilator-associated pneumonia caused by Acinetobacter baumannii

Vitamin D level is associated with mortality predictors in ventilator-associated pneumonia caused by Acinetobacter baumannii

Vitamin D: Way More Important in Critical Care Than We May Have Recognized

The Effects of Initial cortisol levels and Vitamin D on Mortality and Hospital Infection Development in Geriatric Patients at Intensive Care Unit

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