Vitamin D deficiency, behavioral atypicality, anxiety and depression in children with chromosome 22q11.2 deletion syndrome

Kelley, Leslie K.; Sanders, Ashley; Beaton, Elliott A.

doi:10.1017/s2040174416000428

Cited by 15 publications

(12 citation statements)

References 101 publications

(163 reference statements)

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“…27 Recently, it has been reported that low vitamin D levels are associated with schizophrenia, depression, and anxiety in the general population. 28 In a cohort study conducted between 2015 and 2017, Fond et al 29 reported hypovitaminosis D in 21.4% of the subjects with no vitamin D supplementation during the previous 12 months. Additionally, this hypovitaminosis D was severely associated with depressive and anxiety symptoms; however, vitamin D supplementation significantly improved these symptoms.…”

Section: Correlations Between the 25(oh)d And Tsh Levels And The Bdi-mentioning

confidence: 99%

The association between anxiety and depression with 25(OH)D and thyroid stimulating hormone levels

Erensoy

2019

NSJ

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Objectives: To evaluate the relationships between the serum levels of these parameters and mood disorders, including depression and anxiety. Methods: One hundred and fifty patients)77 with anxiety and 73 with depression), aged 18 to 79 years old, who were referred to the Neuro Psychiatry Clinic of Uskudar University in Istanbul, Turkey were included in this study from June 2018 to December 2018. According to the Beck Anxiety Inventory and Beck Depression Inventory II results, the anxiety patients met the mild and moderate anxiety criteria and the depression patients met the moderate and severe depression criteria, respectively. Venous blood samples were collected after overnight fasting, and the 25)OH)D and thyroid stimulating hormone)TSH) levels were measured. Results: The data showed a significantly higher TSH level in the females when compared to their male counterparts in the severe depression subgroup)p=0.011). Conclusion: A serum TSH evaluation may be considered as a useful biochemical marker for more efficient depression management.

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Section: Correlations Between the 25(oh)d And Tsh Levels And The Bdi-mentioning

confidence: 99%

The association between anxiety and depression with 25(OH)D and thyroid stimulating hormone levels

Erensoy

2019

NSJ

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“…Kelly L conducted a study which demonstrated that vitamin D insufficiency might relate to higher levels of anxiety and depression, in turn contributing to the elevated risk of psychosis in children with chromosome 22q11.2 deletion syndrome (22q11.2DS). This syndrome is a complex developmental disorder with serious medical, cognitive and emotional symptoms in their lifespan [ 23 ].…”

Section: Reviewmentioning

confidence: 99%

The Role of Vitamin D in Brain Health: A Mini Literature Review

Anjum¹,

Jaffery²,

Fayyaz³

et al. 2018

Cureus

109

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Vitamin D is vital for our body as it regulates calcium homeostasis and maintains bone integrity. In this article, we will discuss how vitamin D aids in the function of neuronal and glial tissue and the many health consequences in a person with vitamin D deficiency. Some of the effects of vitamin D deficiency that will be discussed include the development of dementia caused by the increase of cerebral soluble and insoluble amyloid-β (Aβ) peptides and a decrease of its anti-inflammatory/antioxidant properties, the link to depression by a reduction of the buffering of increased calcium in the brain, and vitamin D deficiency in expecting mothers linking to the development of autism and schizophrenic-like disorders, hypoxic brain injury, and other mental illnesses. Lastly, we will discuss how vitamin D deficiency is linked to the development of diabetes mellitus, its role in neuronal development and a decrease of microglial inflammatory function leading to increased brain infections.

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“…Among the different mechanisms by which hypoparathyroidism contributes to hypocalcemia, there is inadequate renal conversion of 25‐hydroxyvitamin D to 1,25‐dihydroxyvitamin D (calcitriol), the active metabolite of vitamin D, which is necessary for intestinal absorption of calcium [21]. Therefore, these patients require treatment with calcium carbonate and calcitriol to correct hypocalcemia [20,22,23].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status and the immune assessment in 22q11.2 deletion syndrome

Legitimo

Bertini

Costagliola

et al. 2020

Clinical and Experimental Immunology

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22q11.2 deletion syndrome (22q11.2DS) is characterized by a heterogeneous phenotype, including alterations in phospho-calcium metabolism and immunodeficiency. We analyzed vitamin D status and the immune assessment, focusing on T cell subpopulations and dendritic cells (DCs) in a cohort of 17 pediatric 22q11.2DS patients and 17 age-matched healthy subjects. As antigen-presenting cells, DCs are the main target of vitamin D, promoting a tolerogenic T cell response. Patients were subdivided into three groups according to the parameters of phospho-calcium metabolism and serum levels of 25OHD: normal values, vitamin D deficiency and hypoparathyroidism. Different degrees of T cell deficiency, ranging from normal to partial T cell numbers, were observed in the cohort of patients. The group with vitamin D deficiency showed a significant reduction of naive T cells and a significant increase of central memory T cells compared to controls. In this group the number of circulating DCs was significantly reduced. DC decrease affected both myeloid and plasmacytoid DC subsets (mDCs and pDCs), with the most relevant reduction involving pDCs. A direct correlation between 25OHD levels and recent thymic emigrant (RTE)and DC number was identified. Despite the limited cohort analyzed, our results show that deficiency of the pDC subset in patients with 22q11.2DS may be included among the causative factors of the progressive increase of risk of autoimmune diseases in these patients. As most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, we suggest a potential role of vitamin D supplementation in preventing autoimmune or proinflammatory diseases in 22q11.2DS.

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Vitamin D deficiency, behavioral atypicality, anxiety and depression in children with chromosome 22q11.2 deletion syndrome

Cited by 15 publications

References 101 publications

The association between anxiety and depression with 25(OH)D and thyroid stimulating hormone levels

The association between anxiety and depression with 25(OH)D and thyroid stimulating hormone levels

The Role of Vitamin D in Brain Health: A Mini Literature Review

Vitamin D status and the immune assessment in 22q11.2 deletion syndrome

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