Vitamin D Deficiency Causes Deficits in Lung Function and Alters Lung Structure

Zosky, Graeme R.; Berry, Luke J.; Elliot, John; James, Alan; Gorman, Shelley; Hart, Prue H.

doi:10.1164/rccm.201010-1596oc

Cited by 305 publications

(264 citation statements)

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“…Various non-vitamin D immunomodulators induced by UVR, like NO (28), may be important for the regulation of immunity (29) and obesity/MetS development (30). Skin exposure to UVR releases NO from skin (28) and could control obesity through NO-dependent effects on mitochondria biogenesis within brown adipose tissue (31).…”

Section: Discussionmentioning

confidence: 99%

Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet

et al. 2014

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The role of vitamin D in curtailing the development of obesity and comorbidities such as the metabolic syndrome (MetS) and type 2 diabetes has received much attention recently. However, clinical trials have failed to conclusively demonstrate the benefits of vitamin D supplementation. In most studies, serum 25-hydroxyvitamin D [25(OH)D] decreases with increasing BMI above normal weight. These low 25(OH)D levels may also be a proxy for reduced exposure to sunlight-derived ultraviolet radiation (UVR). Here we investigate whether UVR and/or vitamin D supplementation modifies the development of obesity and type 2 diabetes in a murine model of obesity. Long-term suberythemal and erythemal UVR significantly suppressed weight gain, glucose intolerance, insulin resistance, nonalcoholic fatty liver disease measures; and serum levels of fasting insulin, glucose, and cholesterol in C57BL/6 male mice fed a high-fat diet. However, many of the benefits of UVR were not reproduced by vitamin D supplementation. In further mechanistic studies, skin induction of the UVR-induced mediator nitric oxide (NO) reproduced many of the effects of UVR. These studies suggest that UVR (sunlight exposure) may be an effective means of suppressing the development of obesity and MetS, through mechanisms that are independent of vitamin D but dependent on other UVR-induced mediators such as NO.Obesity has significant effects on our health and wellbeing: obese people have increased comorbidities resulting from cardiovascular disease, type 2 diabetes, breast and colon cancers, dementia, and depression. Vitamin D deficiency is recognized as a health problem affecting many individuals worldwide (1) and may contribute to the development of obesity. Insufficient levels of vitamin D are associated with obesity, and obese people are more likely than others to be vitamin D deficient (reviewed in Earthman et al.

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Section: Discussionmentioning

confidence: 99%

Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet

et al. 2014

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“…Recent studies suggest that vitamin D has a role in lung growth, preserving lung function, and preventing pulmonary infection (1)(2)(3)(4)(5)(6)(7). The largest study comes from the Third National Health and Nutrition Examination Survey (NHANES III) data, which showed in healthy adults those with the highest 25-hydroxyvitamin D (25-OHD) levels had significantly higher FVC and FEV 1 than those with the lowest 25-OHD levels (3).…”

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confidence: 99%

Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis

et al. 2014

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Rationale: Recent literature suggests vitamin D has an effect on lung function and on the lung's ability to fight infection, both important in the cystic fibrosis (CF) population as predictors of morbidity and mortality.Objectives: Our study assessed associations between vitamin D and % predicted lung function, pulmonary exacerbations, and first Pseudomonas aeruginosa infection in children with CF. We hypothesized that children with CF who have 25-hydroxy vitamin D (25-OHD) levels less than 30 mg/L would have lower % predicted lung function and more pulmonary exacerbations than those with 25-OHD greater than or equal to 30 mg/L. Measurements and Main Results:The prevalence of vitamin D deficiency and insufficiency increased slowly through adolescence. The rate of exacerbations for the deficient vitamin D group, aged 15 to 18 years, was 13.1 per 10 patient-years, significantly higher than 4.3 per 10 patient-years for the insufficient and sufficient vitamin D groups (P , 0.05), which were not significantly different There were no differences between vitamin D groups in pulmonary function or incidence of first P. aeruginosa infection, which was about 2 per 10 patient-years.Conclusions: Higher 25-OHD levels in children with CF were associated with lower rates of pulmonary exacerbations and, in adolescents, higher FEV 1 .

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“…The offspring of the vitamin D deficient mice -also deficient in vitamin D -had statistically significantly smaller lungs than normal: about 18% smaller in female offspring and 28% smaller in males 7 . "Our point was that vitamin D deficiency isn't causing gross structural changes in the lung, but it might be slowing down lung growth, " Zosky says.…”

Section: Deficiency As Cause?mentioning

confidence: 97%

“…The decline was so steep it is comparable to the effects of smoking 6 . And a 2011 study in mice found that vitamin D deficiency causes deficits in lung function 7 .…”

Section: Searching For Proofmentioning

confidence: 99%

Nutrition: The vitamin D complex

Singer

2012

Nature

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Vitamin D Deficiency Causes Deficits in Lung Function and Alters Lung Structure

Cited by 305 publications

References 46 publications

Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet

Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet

Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis

Nutrition: The vitamin D complex

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