Vitamin D Deficiency, Excessive Daytime Sleepiness: An Epiphenomenon or a “Chicken or an Egg—Which Came First” Issue?

Ganguly, Gautam

doi:10.5664/jcsm.2684

Cited by 3 publications

(1 citation statement)

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“…Short sleep duration may be related to less outside activity and sun exposure and could have been a cause of low serum vitamin D levels in these subjects. In addition, melanin, which is typically secreted during nocturnal rapid eye movement sleep, may be associated with skin colorization and vitamin D levels . In contrast, it is possible that lower serum vitamin D levels could cause other symptoms such as chronic rhinitis, which might account for the poorer sleep and shorter sleep duration in these subjects …”

Section: Discussionmentioning

confidence: 99%

Association Between Self‐Reported Sleep Duration and Serum Vitamin D Level in Elderly Korean Adults

Kim

Chang

Kim

et al. 2014

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

Association Between Self‐Reported Sleep Duration and Serum Vitamin D Level in Elderly Korean Adults

Kim

Chang

Kim

et al. 2014

J American Geriatrics Society

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Linking Vitamin D and Sleep

Archontogeorgis

Nena

Steiropoulos

2020

Neurological Modulation of Sleep

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Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank Study

Wang

Zhou

et al. 2020

Diabetes Care

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Circulating vitamin D concentrations have been associated with the risk of type 2 diabetes (T2D), but the results are inconsistent. Emerging evidence suggests that vitamin D metabolism is linked to sleep behaviors. We investigated the prospective association between serum 25-hydroxyvitamin D (25OHD) and the risk of incident T2D and whether such association was modified by sleep behaviors. RESEARCH DESIGN AND METHODSThe study included 350,211 individuals free of diabetes in the UK Biobank. Serum 25OHD (nmol/L) concentrations were measured. Five sleep behaviors including sleep duration, insomnia, snoring, chronotype, and daytime sleepiness were included to generate overall sleep patterns, defined by healthy sleep scores. We also calculated genetic risk scores of sleep patterns. RESULTSDuring a median follow-up of 8.1 years, we documented 6,940 case subjects with incident T2D. We found that serum 25OHD was significantly associated with a lower risk of incident T2D, and the multivariate adjusted hazard ratio (HR) (95% CI) per 10 nmol/L increase was 0.88 (0.87-0.90). We found a significant interaction between 25OHD and overall sleep patterns on the risk of incident T2D (P for interaction 5 0.002). The inverse association between high 25OHD and T2D was more prominent among participants with healthier sleep patterns. Among the individual sleep behaviors, daytime sleepiness showed the strongest interaction with 25OHD (P for interaction 5 0.0006). The reduced HR of T2D associated with high 25OHD appeared to be more evident among participants with no frequent daytime sleepiness compared with those with excessive daytime sleepiness. The genetic variations of the sleep patterns did not modify the relation between 25OHD and T2D. CONCLUSIONSOur study indicates that higher serum 25OHD concentrations are associated with a lower risk of incident T2D, and such relations are modified by overall sleep patterns, with daytime sleepiness being the major contributor.Vitamin D is a fat-soluble steroid hormone essential for calcium homeostasis and bone health (1,2). Several randomized controlled trials have explored the role of supplemental vitamin D in preventing cancer and cardiometabolic diseases in recent years (3-5). However, the effects of vitamin D supplementation on the risk of type 2 diabetes

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Vitamin D Deficiency, Excessive Daytime Sleepiness: An Epiphenomenon or a “Chicken or an Egg—Which Came First” Issue?

Cited by 3 publications

References 4 publications

Association Between Self‐Reported Sleep Duration and Serum Vitamin D Level in Elderly Korean Adults

Association Between Self‐Reported Sleep Duration and Serum Vitamin D Level in Elderly Korean Adults

Linking Vitamin D and Sleep

Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank Study

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