1983
DOI: 10.1172/jci110947
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Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.

Abstract: A B S T R A C T The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies… Show more

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Cited by 66 publications
(35 citation statements)
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“…This results in marked declines in circulating levels of 1,25(OH) 2 D. Studies in humans show that vitamin D deficiency is associated with muscle weakness and atrophy [16,28,29]. At the cellular level, vitamin D deficiency impairs intracellular calcium kinetics and muscle cell contractility [8,9], mitochondrial metabolism [10,11] and protein synthesis [12,13]. Treatment with vitamin D corrects these impairments [14,30] as well as restoring strength and improving balance in vitamin D deficient humans [16,29,31].…”
Section: Discussionmentioning
confidence: 99%
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“…This results in marked declines in circulating levels of 1,25(OH) 2 D. Studies in humans show that vitamin D deficiency is associated with muscle weakness and atrophy [16,28,29]. At the cellular level, vitamin D deficiency impairs intracellular calcium kinetics and muscle cell contractility [8,9], mitochondrial metabolism [10,11] and protein synthesis [12,13]. Treatment with vitamin D corrects these impairments [14,30] as well as restoring strength and improving balance in vitamin D deficient humans [16,29,31].…”
Section: Discussionmentioning
confidence: 99%
“…Treatment with vitamin D corrects these impairments [14,30] as well as restoring strength and improving balance in vitamin D deficient humans [16,29,31]. Despite the fact that vitamin D deficiency is associated with muscle loss [12,13] and weakness [16,28,29], which may contribute to the significant muscle atrophy, weakness, and widespread disability experienced by patients with ESRD, the current focus of vitamin D treatment for the control of SHPT, as outlined in the current K/DOQI guidelines [5], is on measuring its effects on bone metabolism and tissue calcification.…”
Section: Discussionmentioning
confidence: 99%
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“…This is especially pertinent for skeletal muscle; because it is a major source of NGF, because there is evidence for a physiological role for vitamin D in other aspects of muscle physiology and because of the cross-talk between neuropathies and myopathies in diabetes mellitus. Degradation of skeletal muscle in vitamin D deficiency is an old observation [31] 2+ uptake and DNA synthesis in myocytes, such that structural modification of these molecules appears to increase their therapeutic potential for the treatment of myopathies [35]. Altered vitamin D metabolism has been shown in both short-term and long-term diabetes [36,37] and decreased concentrations of 1,25-(OH) 2 D 3 are commonly observed, despite the different calcium balances.…”
Section: Discussionmentioning
confidence: 99%
“…The latter two effects are probably mediated via the interaction of vitamin D with the vitamin D receptor (VDR) as VDR knock-out mice suffer from abnormal muscle development and deregulated expression of myogenic regulatory factors [8]. The impact of vitamin D on muscle is also reflected by the increase in muscle mass and decreased rate of myofibrillar protein degradation after vitamin D administration to deficient rats [9]. Also, in humans, vitamin D administration in vitamin D-deficient people induces increases in muscle size and strength, and an increased proportion and size of type II fibres [10].…”
Section: Introductionmentioning
confidence: 99%