Vitamin D deficiency in adult patients with ulcerative colitis: Prevalence and relationship with disease severity, extent, and duration

Law, Arjun; Dutta, Usha; Kochhar, Rakesh; Vaishnavi, Chetana; Kumar, Sumit; Noor, Talha; Bhadada, Sanjay Kumar; Singh, Kartar

doi:10.1007/s12664-019-00932-z

Cited by 24 publications

(20 citation statements)

References 33 publications

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“…In addition to its well-recognized roles in calcium and bone homeostasis, the physiological roles of vitamin D also include immunomodulation and in critically ill patients [ 131 ], and there are well-documented associations between vitamin D deficiency and infection rates [ 132 ], renal and respiratory failure [ 133 , 134 ], sepsis [ 135 ], and mortality [ 136 ]. There have been a number of studies in which an association between vitamin D deficiencies have also been associated with immunological disorders, such as multiple sclerosis [ 137 ], ulcerative colitis [ 138 ], Crohn’s disease [ 139 ], and asthma [ 140 ].…”

Section: Immunonutritionmentioning

confidence: 99%

Could Vitamins Help in the Fight Against COVID-19?

et al. 2020

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There are limited proven therapeutic options for the prevention and treatment of COVID-19. The role of vitamin and mineral supplementation or “immunonutrition” has previously been explored in a number of clinical trials in intensive care settings, and there are several hypotheses to support their routine use. The aim of this narrative review was to investigate whether vitamin supplementation is beneficial in COVID-19. A systematic search strategy with a narrative literature summary was designed, using the Medline, EMBASE, Cochrane Trials Register, WHO International Clinical Trial Registry, and Nexis media databases. The immune-mediating, antioxidant and antimicrobial roles of vitamins A to E were explored and their potential role in the fight against COVID-19 was evaluated. The major topics extracted for narrative synthesis were physiological and immunological roles of each vitamin, their role in respiratory infections, acute respiratory distress syndrome (ARDS), and COVID-19. Vitamins A to E highlighted potentially beneficial roles in the fight against COVID-19 via antioxidant effects, immunomodulation, enhancing natural barriers, and local paracrine signaling. Level 1 and 2 evidence supports the use of thiamine, vitamin C, and vitamin D in COVID-like respiratory diseases, ARDS, and sepsis. Although there are currently no published clinical trials due to the novelty of SARS-CoV-2 infection, there is pathophysiologic rationale for exploring the use of vitamins in this global pandemic, supported by early anecdotal reports from international groups. The final outcomes of ongoing trials of vitamin supplementation are awaited with interest.

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Section: Immunonutritionmentioning

confidence: 99%

Could Vitamins Help in the Fight Against COVID-19?

et al. 2020

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“…The study also revealed that a little less than two-third of study participants have a positive attitude towards adult vitamin D service provision in Ethiopia which has a lot of implication for capacity building of HCWs as it may lead to misdiagnosis of de ciency by frontline health workers which leads to complications of health conditions due to shortage of the mineral considered in this study (8,9).…”

Section: Discussionmentioning

confidence: 80%

“…This nding is similar with the ndings of similar studies done in Australia and New Zealand (9, 10) while it is lower than the nding in Saudi Arabia (23). This nding is really critical in the sense that if HCWs themselves have a knowledge gap then it will be di cult to manage and treat health conditions due to vitamin D de ciency which will exacerbate ill health conditions among adults (8,9,24).…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of adult vitamin D de ciency is increasing even in recent years (6,7). The health consequences of de ciency in vitamin D among adults have also been witnessed in several studies (5,8,9). Health care workers (HCWs) should therefore consistently educate their communities on the uses of vitamin D, its sources and possible health consequences.…”

Section: Introductionmentioning

confidence: 99%

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Knowledge, attitude and practice of health care workers on measuring adult vitamin D level, diagnosis of deficiency, and management of consequent health conditions in three ecologies of Ethiopia: A cross-sectional study

Mekonnen

Feleke

Desalegn

et al. 2020

Preprint

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Background: Vitamin D is essential for health and its shortage exacerbate overall mortality. Health care workers (HCWs) need to educate on its uses and sources although studies indicate their low level of practice. The main aim of this study is therefore to assess the knowledge, attitude and practice of measuring adult vitamin D status, diagnosis of deficiency and managing health consequences among HCWs in Ethiopia.Methods: This study was conducted in three ecologies covering lowland, midland and highland districts. A total of 405 health care workers with different levels were interviewed. Tablets were used for data collection to archive in a cloud server. Data were exported to Stata version 14 software for cleaning and analysis. Rates were computed and Chi-square test was used to compare differences between the two groups. Binary logistic regression was used to measure the strength, direction and significance of association between different covariates and the practice of HCWs.Result: The level of knowledge, positive attitude and good practice in measuring adult vitamin D status, diagnosis of deficiency and managing health consequences among HCWs was 210(51.8%), 261(63.5%) and 195(47.4%) respectively. The odds of good practice in the provision of adult vitamin D service were AOR=6.87: 95% CI (3.57, 13.21) and AOR= 2.20: 95% CI (1.23, 3.92) times higher among HCWs in Addis Ababa and highlands compared with those working in lowlands. Good practice among clinicians was AOR=4.26: 95% CI (1.48, 12.25) times higher compared with those working in leadership positions. The likelihood was AOR=1.96: 95% CI (1.19, 3.23) times higher among those with good knowledge compared with those with poor knowledge. Besides, good practice in adult vitamin D service provision was AOR=2.30: 95% CI (1.40, 3.78) times higher among those with positive attitude compared with those who had negative attitude.Conclusions: A little over half of HCWs have good knowledge and close to two-third of them has positive attitude while less than half of them have good practice on adult vitamin D deficiency. Besides, HCWs residential ecology, clinical position, knowledge and attitude is associated with good practice on adult vitamin D. It is essential to provide rigorous and continues training for HCWs focusing on their deployment ecology.

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“…The prevalence of adult vitamin D de ciency is increasing even in recent years (6,7). The health consequences of a de ciency in vitamin D among adults have also been witnessed in several studies (5,8,9). Health care workers (HCWs) should therefore consistently educate their communities on the uses of vitamin D, its sources, and possible health consequences.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude and practice of health care workers on measuring adult vitamin D level, diagnosis of deficiency, and management of consequent health conditions in three ecologies of Ethiopia: A cross-sectional study

Mekonnen

Feleke

Desalegn

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Vitamin D is essential for health and its shortage exacerbates overall mortality. Health care workers (HCWs) need to educate on its uses and sources although studies indicate their low level of practice. The main aim of this study is therefore to assess the knowledge, attitude and practice of measuring adult vitamin D status, diagnosis of deficiency and managing health consequences among HCWs in Ethiopia. Methods: This study was conducted in three ecologies covering lowland, midland and highland districts. A total of 405 health care workers with different levels were interviewed. Tablets were used for data collection to archiving in a cloud server. Data were exported to Stata version 14 software for cleaning and analysis. Rates were computed and the Chi-square test was used to compare differences between the two groups. Binary logistic regression was used to measure the strength, direction and significance of the association between different covariates and the practice of HCWs.Result: The level of knowledge, positive attitude and good practice in measuring adult vitamin D status, diagnosis of deficiency and managing health consequences among HCWs was 210 (51.8%), 261(63.5%) and 195(47.4%) respectively. The odds of good practice in the provision of adult vitamin D service were AOR=6.87: 95% CI (3.57, 13.21) and AOR= 2.20: 95% CI (1.23, 3.92) times higher among HCWs in Addis Ababa and highlands compared with those working in lowlands. Good practice among clinicians was AOR=4.26: 95% CI (1.48, 12.25) times higher compared with those working in leadership positions. The likelihood was AOR=1.96: 95% CI (1.19, 3.23) times higher among those with good knowledge compared with those with poor knowledge. Besides, good practice in adult vitamin D service provision was AOR=2.30: 95% CI (1.40, 3.78) times higher among those with positive attitude compared with those who had negative attitude.Conclusions: A little over half of HCWs have good knowledge and close to two-thirds of them have positive attitude while less than half of them have good practice on adult vitamin D deficiency. Besides, HCWs’ residential ecology, clinical position, knowledge and attitude is associated with good practice on adult vitamin D. It is essential to provide rigorous and continuous training for HCWs focusing on their deployment ecology.

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Vitamin D deficiency in adult patients with ulcerative colitis: Prevalence and relationship with disease severity, extent, and duration

Cited by 24 publications

References 33 publications

Could Vitamins Help in the Fight Against COVID-19?

Could Vitamins Help in the Fight Against COVID-19?

Knowledge, attitude and practice of health care workers on measuring adult vitamin D level, diagnosis of deficiency, and management of consequent health conditions in three ecologies of Ethiopia: A cross-sectional study

Knowledge, attitude and practice of health care workers on measuring adult vitamin D level, diagnosis of deficiency, and management of consequent health conditions in three ecologies of Ethiopia: A cross-sectional study

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