Vitamin D Deficiency in Adults: When to Test and How to Treat

Kennel, Kurt A.; Drake, Matthew T.; Hurley, Daniel L.

doi:10.4065/mcp.2010.0138

Cited by 557 publications

(449 citation statements)

References 24 publications

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“…Vitamin D deficiency is common in CKD, which has been attributed to many factors such as reduced sun exposure, decreased vitamin D-binding protein, proteinuria, reduced dietary intake, advanced age, malabsorption, and down-regulation of megalin levels. 8,15,26,27 In Middle Eastern and South Asian developing countries, levels of 25(OH)D < 10 ng/mL were reported in 50% of the population and higher risk was noted among females. 28 Of females aged 24-77 years living in Rabat, 91% had lower than 30 ng/mL 25(OH)D, and female sex was considered a predictor of 25(OH)D deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…4,6 Vitamin D deficiency is quite common worldwide affecting approximately 30-50% of the global population, and measuring 25-hydroxyvitamin D (25(OH)D) is the best method for determining vitamin D deficiency due to its longer half-life. [8][9][10] Values of 25(OH)D above 30 ng/mL are considered normal. 8,10,11 Vitamin D plays a crucial role in bone and calcium metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Values of 25(OH)D above 30 ng/mL are considered normal. 8,10,11 Vitamin D plays a crucial role in bone and calcium metabolism. In addition, it has beneficial effects on the immune system, blood pressure regulation, vascular endothelial function, and body growth and development.…”

Section: Introductionmentioning

confidence: 99%

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Arterial stiffness and 25-hydroxyvitamin D levels in chronic kidney disease patients

Akdam

Alp

2017

Rev. Assoc. Med. Bras.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Arterial stiffness and 25-hydroxyvitamin D levels in chronic kidney disease patients

Akdam

Alp

2017

Rev. Assoc. Med. Bras.

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“…Despite its prevalence, universal screening for vitamin D deficiency has not been promoted due to the high cost of serum assays. As such, screening has been reserved only for patients at high risk for deficiency [6].…”

Section: Epidemiology Of Vitamin D Deficiencymentioning

confidence: 99%

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

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Purpose To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.Methods A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

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“…5) [5,6]. Kitos būklės: hipomagnezemija (mažina PTH sekreciją), sepsis, tumoro lizės sindromas, "alkanų kaulų" sindromas, ūminis ir lėtinis inkstų nepakankamumas, hemodializė, pankreatitas, pakartotiniai kraujo perpylimai -susiformuoja kalcio ir citrato kompleksai [4,7].…”

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Hipokalcemija ‒ Žinoma, Bet Neatpažįstama Būklė. Atvejo Pristatymas Ir Trumpa Literatūros Apžvalga

Narkutė

Damulevičienė

2017

Medicinos Teorija Ir Praktika

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SANTRAUKAReikšminiai žodžiai: hipokalcemija, pirminis hipoparatiroidizmas, ilgas QT intervalas, parkinsonizmas. Hipokalcemija kliniškai pasireiškia nervų ir raumenų sistemų simptomais: tetanija, traukuliais, laringospazmu, aritmijomis, sunkina širdies nepakankamumą. Viena hipokalcemijos priežasčių yra pirminis hipoparatiroidizmas -retas endokrininis sutrikimas, kuriam būdinga hipokalcemija, hiperfosfatemija ir maža parathormono (PTH) koncentracija kraujyje. Hipokalcemiją taip pat gali sukelti pseudohipoparatiroidizmas, kai PTH koncentracija normali ar padidėjusi, vitamino D trūkumas, ūminis ir lėtinis inkstų nepakankamumas, pankreatitas, įvairūs medikamentai. Pristatomas paciento, kuriam diagnozuota simptominė hipokalcemija dėl pirminio hipoparatiroidizmo, klinikinis atvejis. Kliniškai stebėtas traukulių priepuolis, galvos smegenų EEG registruotas epileptiforminis aktyvumas, EKG -ilgas QT intervalas, o galvos smegenų KT buvo nustatyti kalcinatai pamato branduolių ir smegenėlių srityse, galimai sukėlę parkinsonizmo simptomus. Skyrus gydymą kalcio gliukonatu į veną, o vėliau koreguojant hipokalcemiją kalcio karbonatu ir alfakalcidoliu, paciento būklė ženkliai pagerėjo, traukuliai nesikartojo, tačiau išlaikyti normalią kalcio koncentraciją kraujyje buvo sudėtinga, EKG išliko ilgas QT intervalas. Pacientas konsultuotas endokrinologo, diagnozuotas pirminis hipoparatiroidizmas. Tolesniam gydymui rekomenduota tęsti kalcio preparatų ir alfakalcidolio vartojimą, ambulatoriškai monitoruoti kalcio ir fosforo koncentraciją kraujyje. ABSTRACTKey words: hypocalcaemia, primary hypoparathyroidism, long QT interval, parkinsonism. Hypocalcaemia affects nervous and muscular systems, the main clinical symptoms include tetany, seizures, laryngospasm and arrythmias, the condition worsens heart failure. Primary hypoparathyroidism is a rare endocrine disorder that causes hypocalcaemia, significantly elevated plasma phosphorus and low parathormone concentration. Hypocalcaemia can also be caused by pseudohypoparathyroidism, when serum concentration of parathormone is normal or elevated, vitamin D deficiency, acute or chronic renal failure, acute pancreatitis, various medication. We present a clinical case of clinically relevant hypocalcaemia due to primary hypoparathyroidism. Clinical presentation included seizures, epileptiformic activity on EEG, long QT interval on ECG, and calcification of basal ganglia and cerebellum that potentially has caused parkinsonism. We started treatment with calcium gluconate intravenously wich was folowed by calcium and alphacalcidol. Patient's condition improved, seizures did not repeat, however it was difficult to maintain normal blood calcium concentration, long QT interval persisted on ECG. The patient was consulted by endocrinologist and diagnosed with primary hypoparathyroidism. For the following treatment it was recommended to continue taking calcium and alphacalcidol, and to monitor blood calcium and phosphorus concentrations.

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Vitamin D Deficiency in Adults: When to Test and How to Treat

Cited by 557 publications

References 24 publications

Arterial stiffness and 25-hydroxyvitamin D levels in chronic kidney disease patients

Arterial stiffness and 25-hydroxyvitamin D levels in chronic kidney disease patients

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Hipokalcemija ‒ Žinoma, Bet Neatpažįstama Būklė. Atvejo Pristatymas Ir Trumpa Literatūros Apžvalga

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