Vitamin-D Deficiency in Asians at Home and in Britain

Hodgkin, Paul; Hine, P; Kay, G; Lumb, G. A.; Stanbury, Sarah

doi:10.1016/s0140-6736(73)93004-3

Cited by 87 publications

(46 citation statements)

References 18 publications

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“…Vitamin D deficiency is prevalent in India. In 1973, Hodgkin first published data regarding vitamin D deficiency [10]. Between 1995 and 2000, studies from north India proved the deficiency of vitamin D in our population [11,12].Subsequently south Indian studies also confirmed it [13][14][15][16].…”

Section: Introductionmentioning

confidence: 62%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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Vitamin D is recognized to serve a wide range of biological functions. The presence of vitamin D receptors on different tissues explains it's diversity of actions. Reduced levels of vitamin D is associated with insulin resistance and increased diabetes risk. The study included 50 normal healthy individuals and 49 type 2 diabetes subjects. Fasting blood glucose, total cholesterol, triglycerides, HDLc, fasting insulin, parathyroid hormone, calcium, albumin and Homeostasis model for assessment of insulin resistance (HOMAIR) were measured in all the study participants. Type 2 diabetes subjects were divided into group 1 with 25 hydroxy vitamin D (25(OH)D) B20 ng/ml and group 2 with 25(OH)D [20 ng/ml. By the results of this study, the mean 25(OH)D level was low (20.09 ng/ml) in type 2 diabetes compared to controls (23.89 ng/ml) and the p value was 0.02. The estimated insulin resistance by HOMAIR was more in group 1 than in group 2 of diabetes with p value of 0.037. The Pearson's correlation-coefficient was negative for 25(OH)D and insulin in type 2 diabetes (r = -0.294), 25(OH)D was negatively correlated with HOMAIR in total subjects. Type 2 diabetes subjects had reduced levels of vitamin D than normal individuals. The insulin resistance was more in vitamin D deficiency state. Hence vitamin D has a role in glucose metabolism, deficiency can result in insulin resistance and diabetes.

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Section: Introductionmentioning

confidence: 62%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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“…Asian immigrants are known to have low plasma 25-OHD values (Preece et al 1973) and to have a low dietary intake of vitamin D (Hodgkin et al 1973). The Asian vegetarian children that we studied had a lower dietary vitamin D intake than the Caucasian children.…”

Section: Discussionmentioning

confidence: 81%

Studies on the measurement of 25-hydroxy vitamin D in human saliva

Fairney

Saphier

1987

Br J Nutr

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1. A competitive protein-binding assay for 25-hydroxy vitamin D (25-OHD) in saliva has been established by adaptation of that previously described for 25-OHD in serum (Fairney et al. 1979).2. Random values of salivary 25-OHD in patients attending hospital for venesection showed a wide range of results (105-1000 pg/ml, n 55). These values corresponded to 1.2% of the total serum values with which they showed a significant relation (r 0.45, P < 0.001).3. There was no relation between salivary 25-OHD and measured serum free 25-OHD in eighteen pairs of saliva and serum studied. METHODS Collection of samplesUnstimulated samples of whole saliva (approximately 2 ml) were collected directly into glass bottles from normal volunteer subjects or patients attending for phlebotomy. Serum was collected simultaneously and all samples were stored in glass bottles at -20" until thawed before assay. Permission to collect these samples was obtained from the Local Ethical Commit tee.The saliva samples contained varying amounts of particulate matter to which 25-OHD3 bound on storage. To obtain a homogenous mixture for assay, the thawed samples were sonicated at amplitude 6 for 30 s before use, using a MSE Soniprep 150 (MSE Scientific Instruments, Crawley, Sussex).

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“…Indian literature uniformly points to low 25(OH) vit D levels in various population studies, despite abundant sunshine being present in the country [5]. However, western literature has reported 25 (OH) vit D deficiencies as being rare in the Indian sub-continent [6]. Though, the last two decades have shown an increase in the series of retrospective and prospective studies, which decipher the epidemiology and clinical significance of 25-hydroxy vitamin D deficiency and its association with several diseases in the Indian population [1,7,8].…”

Section: Introductionmentioning

confidence: 99%