Vitamin D deficiency in children and adolescents with obesity: a meta-analysis

Fiamenghi, Verônica Indicatti; Mello, Elza Daniel de

doi:10.1016/j.jped.2020.08.006

Cited by 100 publications

(80 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 40 , 41 Previous studies have reported that there is a link between obesity and low levels of vitamin D in the body. 42–44 It is not yet known what the cause of vitamin D deficiency is, that is, whether it is due to insufficient sunlight exposure, low vitamin D intake, or vitamin D receptor gene polymorphism. 45–48 One probable mechanism of vitamin D deficiency associated with obesity is the decreased bioavailability of vitamin D (cholecalciferol/vitamin D3) from skin and food as it accumulates in adipocytes, and people who are obese will thus be less able to convert vitamin D into the active form.…”

Section: Discussionmentioning

confidence: 99%

The Moderate Correlation Between 25(OH)D Serum and Saliva in Healthy People with Low Vitamin D Intake

Sari¹,

Sari²,

Laksmi³

et al. 2021

IJGM

View full text Add to dashboard Cite

Purpose The routine examination of vitamin D levels is carried out by checking serum 25(OH)D levels, while serum 1.25(OH)D levels are less frequently utilized. The proposition that testing for salivary vitamin D can show a correlation with serum levels in healthy people is questionable, especially with low vitamin D intake. This study aimed to find the correlation between vitamin D levels, which were assessed as 25(OH)D and 1.25(OH)D in saliva, and serum 25(OH)D and 1.25(OH)D levels in people with low vitamin D intake. Patients and Methods This study is a cross-sectional study involving healthy men and women, aged 18–60 years, carried out from August to November, 2020, in North Sumatra Province, Indonesia. The parameters studied were the 25(OH)D and 1.25(OH)D levels in saliva and serum, and vitamin D intake. The statistical analysis used was the Spearman correlation test, performed to determine the correlation between each parameter. Results This study involved 56 study subjects, who were rural adults (male or female) with a 78.6% deficiency in 25(OH)D found by examining saliva, and a 76.8% deficiency found by examining the serum. All of the subjects were categorized as having low vitamin D intake (less than 15 micrograms per day). The analysis showed a moderate correlation between levels of saliva 25(OH)D and serum 25(OH)D ( p = 0.424), and a weak correlation between levels of saliva 1.25(OH)D and serum 25(OH)D ( p = 0.339). Conclusion In people with low vitamin D intake, there was a moderate correlation between serum 25(OH)D and saliva, but a weak correlation was found in the 1.25(OH)D assay. The use of saliva 25(OH)D levels to detect 25(OH)D in the circulation is a possible non-invasive alternative to serum testing.

show abstract

Section: Discussionmentioning

confidence: 99%

The Moderate Correlation Between 25(OH)D Serum and Saliva in Healthy People with Low Vitamin D Intake

Sari¹,

Sari²,

Laksmi³

et al. 2021

IJGM

View full text Add to dashboard Cite

show abstract

“…Kang reported that during the coronavirus disease-2019 (COVID-19) pandemic, increased childhood obesity and vitamin D de ciencies were observed [28]. Meta-analysis reported that children and adolescents with obesity have higher risk of vitamin D de ciency [29][30]. Also, A positive association between obesity and lower 25(OH)D serum concentration was found among Chinese adults [31].…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Vitamin D, Retinol, Zinc and CRP in Relation To Obesity Among Children and Adolescents

Zou

Huang

Zhao

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The aim of this study was to examine the possible association between serum micronutrients (vitamin D, retinol, Zinc ), C-reactive protein (CRP) and obesity among children and adolescents. Methods: Weight and height were measured and serum 25-hydroxy vitamin D, serum retinol, serum Zinc and CRP were measured in 2818 children and adolescents(6-17 years of age), using the data of 10 investigation sites in Zhejiang Province. The difference of micronutrients (vitamin D, retinol, zinc), CRP among different BMI status were explored by ANOVA and chi-square test. The associated factors of micronutrients and CRP of overweight and obesity were explored by multifactor analysis.Results: There were significant differences between male students and female students on BMI, 25(OH)D3, CRP, and there were significant differences between children and adolescents and between students living in urban area and rural area on BMI, 25(OH)D3, retinol, zinc(p < 0.05). There were significant differences on 25(OH)D3 and CRP level, and on retinol level among children and adolescents with different nutritional conditions (p < 0.05). In multifactor analysis, we found that gender(OR=0.626, 95%CI:0.486-0.806), living area (OR=0.666, 95%CI:0.515-0.860), age group(OR=0.894, 95%CI:0.856-0.934), high CRP concentration (OR=1.084,95%CI:1.046-1.122) and appropriate retinol level (OR=1.536, 95%CI:1.185-1.991) were associated with students with obesity. Conclusion: Gender, living area, age group, CRP concentration and vitamin A status were associated with children and adolescents with overweight and obesity. More attention in the intervention of overweight and obesity should be paid to boys living in urban areas, and high serum CRP and retinol level should also be concerned.

show abstract

“…Conversely, vitamin D, which is known to play a role in bone health and metabolism throughout lifespan, is frequently deficient in individuals with obesity; a European study found around 39% prevalence of 25(OH)D deficiency (< 10 ng/mL) among adolescents [ 108 ], while in a recent prospective [ 109 , 110 ] cohort study on pre- and post-bariatric surgery adolescents, basal levels of 25-hydroxyvitamin D were insufficient in 37% of participants ( n = 242). The pandemic increase in obesity is inversely associated with vitamin D levels, which is known to be stored in fat tissue, resulting in an increased risk of impaired glycemic control and metabolic syndrome in the general population [ 111 ].…”

Section: Nutritional Status and Nutritional Risksmentioning

confidence: 99%

Bariatric Surgery in Adolescents: To Do or Not to Do?

et al. 2021

View full text Add to dashboard Cite

Pediatric obesity is a multifaceted disease that can impact physical and mental health. It is a complex condition that interweaves biological, developmental, environmental, behavioral, and genetic factors. In most cases lifestyle and behavioral modification as well as medical treatment led to poor short-term weight reduction and long-term failure. Thus, bariatric surgery should be considered in adolescents with moderate to severe obesity who have previously participated in lifestyle interventions with unsuccessful outcomes. In particular, laparoscopic sleeve gastrectomy is considered the most commonly performed bariatric surgery worldwide. The procedure is safe and feasible. The efficacy of this weight loss surgical procedure has been demonstrated in pediatric age. Nevertheless, there are barriers at the patient, provider, and health system levels, to be removed. First and foremost, more efforts must be made to prevent decline in nutritional status that is frequent after bariatric surgery, and to avoid inadequate weight loss and weight regain, ensuring successful long-term treatment and allowing healthy growth. In this narrative review, we considered the rationale behind surgical treatment options, outcomes, and clinical indications in adolescents with severe obesity, focusing on LSG, nutritional management, and resolution of metabolic comorbidities.

show abstract

Vitamin D deficiency in children and adolescents with obesity: a meta-analysis

Cited by 100 publications

References 36 publications

The Moderate Correlation Between 25(OH)D Serum and Saliva in Healthy People with Low Vitamin D Intake

The Moderate Correlation Between 25(OH)D Serum and Saliva in Healthy People with Low Vitamin D Intake

Serum Levels of Vitamin D, Retinol, Zinc and CRP in Relation To Obesity Among Children and Adolescents

Bariatric Surgery in Adolescents: To Do or Not to Do?

Contact Info

Product

Resources

About