Vitamin D Deficiency in Community-Dwelling Elderly Is Not Associated with Age-Related Macular Degeneration

Cougnard‐Grégoire, Audrey; Merle, Bénédicte M. J.; Korobelnik, Jean‐François; Rougier, Marie-Bénédicte; Delyfer, Marie-Noëlle; Féart, Catherine; Goff, Mélanie Le; Dartigues, Jean‐François; Barberger‐Gateau, Pascale; Delcourt, Cécile

doi:10.3945/jn.115.214387

Cited by 27 publications

(15 citation statements)

References 40 publications

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“…No specific association was found between vitamin D deficiency and AMD in a population of elderly subjects living in Bordeaux, France (Cougnard-Gregoire et al, 2015). Similar results were obtained in a population of Israeli individuals aged over 60 years (Golan et al, 2011).…”

Section: Epidemiologysupporting

confidence: 77%

Can vitamin D protect against age-related macular degeneration or slow its progression?

et al. 2019

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Dietary vitamin D plays an important role in maintaining proper vision. Age-related macular degeneration (AMD) is a complex eye disease with unknown pathogenesis. Studies on dietary supplementation and AMD occurrence and progression have produced conflicting results. In its advanced stage, AMD may be associated with apoptosis, pyroptosis or necroptosis of retinal cells. Vitamin D has been reported to play a role in modulating each of these programmed death pathways. Vitamin D is a modulator of the immune system and it acts synergistically with two members of the regulators of complement activation family H and I, whose specific variants are the most important genetic factors for AMD pathogenesis. Angiogenesis is an essential component of the neovascular form of AMD, the most devastating type of the disease and vitamin D is reputed to possess antiangiogenic properties. Cellular DNA damage response is weakened in AMD patients and so it is another process that can be modulated by vitamin D. Finally, impaired autophagy is claimed to play a role in AMD and emerging evidence suggests that vitamin D can influence autophagy. Therefore, several pathways of vitamin D metabolism and AMD pathogenesis overlap, suggesting that vitamin D could modulate the course of AMD.

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Section: Epidemiologysupporting

confidence: 77%

Can vitamin D protect against age-related macular degeneration or slow its progression?

et al. 2019

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“…Plasma 25(OH)D concentrations were assessed from fasting blood samples collected at baseline and stored at -80°C, with a one-step immunoassay (ARCHITECT 25-OH Vitamin D assay, Abbott Diagnostics, Germany) as described elsewhere [23]. Instead of using raw plasma 25(OH)D concentration and adjusting for season in multivariate models as done in several previous analyses, we used a "de-seasonalized" plasma 25(OH)D concentration variable [15,24].…”

Section: Plasma 25(oh)d Assessmentmentioning

confidence: 99%

“…The number of drugs consumed per day was considered as a proxy of co-morbidities. Vitamin D supplementation use was recorded at baseline as earlier agreed according to the anatomical therapeutic chemical (ATC) classification [23]. Practice of physical activity was defined as regular when doing sport regularly, or having at least one hour of leisure activity per day [33].…”

Section: Other Variablesmentioning

confidence: 99%

“…Practice of physical activity was defined as regular when doing sport regularly, or having at least one hour of leisure activity per day [33]. This exposure variable included outdoor leisure activities and was used as a proxy for significant time spent outdoors in our analyses [23]. Overall diet quality was assessed by the Mediterranean diet score [34].…”

Section: Other Variablesmentioning

confidence: 99%

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Associations of lower vitamin D concentrations with cognitive decline and long‐term risk of dementia and Alzheimer's disease in older adults

Féart

Helmer

Merle

et al. 2017

Alzheimer's & Dementia

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126

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“…However, not all studies support this association (11–14). Only three previous studies were conducted in racially/ethnically diverse samples, inclusive of non-Hispanic whites (2, 12), non-Hispanic blacks (2, 12), Mexican Americans (2), and Koreans (9), limiting our understanding of this association in racial/ethnic groups such as African Americans, who have one of the highest burdens of vitamin D deficiency (15).…”

Section: Introductionmentioning

confidence: 97%

Vitamin D status and prevalent early age-related macular degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study

Millen

Nie

Sahli

et al. 2017

The Journal of nutrition, health and aging

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Objective Vitamin D status has been hypothesized to protect against development of early age-related macular degeneration (AMD) via its anti-inflammatory properties and its possible beneficial influence on blood pressure control. We investigated the association between vitamin D status and prevalent early AMD in a community-based cohort. Design This was a cross-sectional study. Setting This was a secondary data analysis of already existing data from the Atherosclerosis Risk in Communities Study (ARIC) cohort study collected from 1990 to 1995. Participants There were 9,734 (7,779 Caucasians, 1,955 African American) ARIC participants (aged 46 to 70 at visit 2 [1990-1992]) with 25(OH)D data available at visit 2, AMD assessment at visit 3 (1993-1995), and complete covariate data. Measurements Vitamin D status was assessed with serum 25-hydroxyvitamin D (25(OH)D) concentrations from bloods drawn at visit 2. Prevalent, early AMD (n=511) was assessed at visit 3 (1993-95) with nonmydriatic retinal photographs of one randomly chosen eye. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for early AMD by categories of 25(OH)D in nmol/L (deficient <30, inadequate 30-<50, and two categories of adequate status: 50-<75 and ≥75). Linear trend was estimated using continuous 25(OH)D concentrations. ORs were adjusted for age, race, and smoking status. We further adjusted for hypertension status to examine if vitamin D status influenced early AMD via its effects on blood pressure. Exploratory analyses of effect modification by age, gender, race and high risk genotypes [Y402H complement factor H (CFH) rs1061170 and the A69S age-related maculopathy susceptibility 2 (ARMS2) rs10490924 polymorphisms] were conducted. Results The prevalence of early AMD was 5%, and 5% of participants were vitamin D deficient. The adjusted OR (95% CIs) for early AMD among those with adequate (≥75 nmol/L) compared to deficient (<30 nmol/L) vitamin D status was 0.94 (0.59-1.50), p-trend=0.86. Further adjustment for hypertension status did not influence results (OR [95% CI]=0.95 [0.59-1.52], p-trend=0.84). Results did not vary significantly by age, race, gender, early AMD subtype (soft drusen or retinal pigment epithelium depigmentation), ARMS2 genotype, or CFH genotype in African Americans. Although the p for multiplicative interaction between 25(OH)D and CFH genotype was 0.06 in Caucasians, OR [95% CIs] for AMD in participants with 25(OH)D ≥50 compared to <50 nmol/L were similar in each CFH genotype and not statistically significant. Conclusions Vitamin D status was not associated with early AMD in this cohort sample.

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Vitamin D Deficiency in Community-Dwelling Elderly Is Not Associated with Age-Related Macular Degeneration

Abstract: These findings underline the very high prevalence of plasma 25(OH)D deficiency in this elderly population but do not support a specific role for vitamin D in AMD.

Cited by 27 publications

References 40 publications

Can vitamin D protect against age-related macular degeneration or slow its progression?

Can vitamin D protect against age-related macular degeneration or slow its progression?

Associations of lower vitamin D concentrations with cognitive decline and long‐term risk of dementia and Alzheimer's disease in older adults

Vitamin D status and prevalent early age-related macular degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study

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