Vitamin D deficiency in first episode psychosis: A case–control study

Crews, Matthieu; Lally, John; Gardner-Sood, Poonam; Howes, Oliver; Bonaccorso, Stefania; Smith, Shubuladè; Murray, Robin M.; Forti, Marta Di; Gaughran, Fiona

doi:10.1016/j.schres.2013.08.036

Cited by 81 publications

(68 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings showed no significant association between those taking antipsychotics and vitamin D level, in line with other studies that showed no effect of antipsychotics on vitamin D level [1,48,49]. It is hypothesized that anti psychotics would cause hypogonadism and might predispose the patient to a higher risk of osteoporosis [50] however, it is not known whether there are direct effects of this class of medications on vitamin D status [1].…”

Section: Discussionsupporting

confidence: 84%

“…No study has evaluated the association between MRSS, BCRS and hypovitaminosis D in schizophrenic patients. Increasing the behavioral and cognitive function would increase outdoor activities and exposure to sunlight [1,48]. Different studies had reported that insufficiency or deficiency of vitamin D is associated with cognitive impairment [1,23,[53][54][55][56].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Azar¹

2017

Ann Nutr Disord & Ther

View full text Add to dashboard Cite

Objectives: To compare the vitamin D status in schizophrenics to that of healthy controls; secondary objectives were to assess the correlation between severe vitamin D deficiency and the severity of schizophrenia symptoms and to evaluate the potential factors influencing this status. Methods:A case-control study, conducted between March and July 2016, recruited 100 patients with schizophrenia and 100 controls with no known psychiatric disorders and matched for age and sex.Results: Schizophrenic patients had a more severe vitamin D deficiency compared to healthy controls (9% vs. 3%). Vitamin D insufficiency was found in 28% of schizophrenic patients compared to 37% in healthy controls (p=0.053). BCRS and MRSS scales were significantly associated with a more severe vitamin D deficiency (p=0.006). We couldn't detect any association between the total PANSS score and its three subscales with vitamin D deficiency (p>0.05). Lebanon has a high prevalence of 25(OH)-D deficiency in adults and older adults [23,24] however, data regarding vitamin D levels in psychiatric patients is still lacking. Therefore, the primary objective of this study was to compare the vitamin D status in schizophrenics to that of healthy controls; secondary objectives were to assess the

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Azar¹

2017

Ann Nutr Disord & Ther

View full text Add to dashboard Cite

show abstract

“…These previous studies however have methodological limitations, including lack of adjustment for ethnicity (Rey-Sanchez et al, 2009;Partti et al, 2010;Doknic et al, 2011;Jamilian et al, 2013), comparison between hospitalized patients and health care workers (Itzhaky et al, 2012) or hospitalized patients and healthy controls recruited by advertisements without control for place of residence (Crews et al, 2013). The healthy controls in the current study were randomly recruited from the same catchment area as the study patients and matched both for ethnicity and other important confounding variables such as gender and age.…”

Section: Discussionmentioning

confidence: 97%

“…One study (N= 138) found significantly lower S-25 OH D in both white and black patients, but not in patients of Asian origin, compared to healthy controls (Crews et al, 2013). The other small study (N= 40) did not find any patient/ control differences (Graham et al, 2014).…”

Section: Introductionmentioning

confidence: 93%

“…A power analysis based on group differences (means and standard deviations) from the previous vitamin D in FEP study (Crews et al, 2013) indicated that a group size of 46 participants would be sufficient to detect real differences given the expected differences and standard deviations. A total of 71 first episode patients (FEP) with a DSM-IV psychotic disorder (Schizophrenia spectrum i.e.…”

Section: Participantsmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

View full text Add to dashboard Cite

Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms.

show abstract

Effect of Vitamin D Supplementation on Outcomes in People With Early Psychosis

et al. 2021

Self Cite

View full text Add to dashboard Cite

IMPORTANCEPeople with psychotic disorders have an increased risk of vitamin D deficiency, which is evident during first-episode psychosis (FEP) and associated with unfavorable mental and physical health outcomes. OBJECTIVE To examine whether vitamin D supplementation contributes to improved clinical outcomes in FEP. DESIGN, SETTING, AND PARTICIPANTSThis multisite, double-blind, placebo-controlled, parallelgroup randomized clinical trial from the UK examined adults 18 to 65 years of age within 3 years of a first presentation with a functional psychotic disorder who had no contraindication to vitamin D supplementation. A total of 2136 patients were assessed for eligibility, 835 were approached, 686 declined participation or were excluded, 149 were randomized, and 104 were followed up at 6

show abstract

Vitamin D deficiency in first episode psychosis: A case–control study

Cited by 81 publications

References 51 publications

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Effect of Vitamin D Supplementation on Outcomes in People With Early Psychosis

Contact Info

Product

Resources

About