Vitamin D Deficiency in Patients With Chronic Tension‐Type Headache: A Case‐Control Study

Prakash, Sanjay; Rathore, Chaturbhuj; Makwana, Prayag; Dave, Ankit; Joshi, Hemant; Parekh, Haresh

doi:10.1111/head.13096

Cited by 35 publications

(17 citation statements)

References 37 publications

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“…Preliminary studies have found an association between vitamin deficiencies and headaches, but large studies on the topic are lacking. 22,23 When examining potential effect modification by gender, we did not observe a statistically significant difference between ORs for number of ACEs and headaches in females and males. The results from observational studies conducted in adults have shown gender differences in the association between headache and ACEs.…”

Section: Discussionmentioning

confidence: 58%

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Adverse Childhood Experiences (ACEs) and Headaches Among Children: A Cross‐Sectional Analysis

et al. 2020

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Objectives This cross‐sectional study examined the association between adverse childhood experiences (ACEs) and history of frequent headaches (including migraine) among children 3‐17 years old using data from the 2016 and 2017 U.S. National Survey of Children’s Health (NSCH). Background ACEs include abuse (physical, emotional, or sexual), parental divorce, death, mental illness, or addiction, and are linked to higher morbidity and mortality in adulthood. A relationship between ACEs and headaches exists among adults, but studies examining the relationship among children are lacking. To our knowledge, no studies have examined the link among children using NSCH data. Methods The NSCH is a nationally representative survey of U.S. children’s physical and emotional well‐being aimed at understanding their health needs. Parental‐reported information was collected on child history of headaches and 9 ACEs for the selected child. The survey collected information on 71,881 children in 2016 and 2017 out of which 61,565 were eligible for the study (age ≥3 years and not missing data on history headaches). Children with missing values for headache, ACEs, or covariates (n = 58,958) were excluded from the final analysis. We used multivariable logistic regression with survey weighting and adjusted for demographics and comorbidities (anxiety, depression, epilepsy, and brain injury) to examine the association between ACEs and headaches overall and stratified by gender. We further assessed the independent relationship between each ACE and headaches. Results In the current study, out of 61,656 children, 26,884 (48.6%) experienced at least 1 ACE and 3426 (6.5%) experienced 4+ ACEs. Overall, compared with children with no ACEs, the adjusted odds of headache were 1.34 times higher among children with 1 reported ACE (95% CI: 1.07, 1.68), 2.15 times higher among children with 2 ACEs (95% CI: 1.66, 2.80), 1.89 times higher among children with 3 ACEs (95% CI: 1.40, 2.53), and 3.40 times higher among children with 4+ ACEs (95% CI: 2.61, 4.43). Females with 3 and 4+ ACEs were somewhat more likely to report headaches compared to males with the same number of ACEs. Individually, no ACE was independently associated with history of headaches except for difficulty due to family’s income (aOR = 2.46, 95% CI: 1.98, 3.06). Conclusion Experiencing one or more ACEs vs none was associated with higher risk of headaches in children, and difficulty due to family’s income was the only ACE independently associated with headaches. Our findings support results of other studies on ACEs and headache in young adults and suggest that adverse ACE‐related health outcomes begin earlier than previously recognized. Additionally, struggling due to low income may represent a constellation of chronic stressors that independently contribute to poor health outcomes in childhood as compared to other individual ACEs. Future research should examine the importance of specific ACE clusters and stressors during childhood.

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Section: Discussionmentioning

confidence: 58%

“…For example, children lacking proper nutrition resulting from limited family financial resources may be at increased risk of headaches. Preliminary studies have found an association between vitamin deficiencies and headaches, but large studies on the topic are lacking …”

Section: Discussionmentioning

confidence: 99%

Adverse Childhood Experiences (ACEs) and Headaches Among Children: A Cross‐Sectional Analysis

et al. 2020

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“…Another study also showed 100 patients with chronic TTH had a significantly higher prevalence of musculoskeletal pain, muscle tenderness and weakness, and bone tenderness score compared to controls [60]. In addition, they showed vitamin D insufficiency was accompanied by an increased risk of chronic TTH [60]. Similarly, Hanci et al found lower 25(OH)D levels in those with headache compared to controls, with not statistically significant difference [53].…”

Section: Vitamin D Deficiency and Tension-type Headachesmentioning

confidence: 95%

“…This muscles hypersensitivity together with and sensory hyperinnervation may exacerbate musculoskeletal pain [22]. Another study also showed 100 patients with chronic TTH had a significantly higher prevalence of musculoskeletal pain, muscle tenderness and weakness, and bone tenderness score compared to controls [60]. In addition, they showed vitamin D insufficiency was accompanied by an increased risk of chronic TTH [60].…”

Section: Vitamin D Deficiency and Tension-type Headachesmentioning

confidence: 99%

“…Based on the studies published to date and summarized in Table 1, vitamin D deficiency is common among patients with TTH: low serum 25(OH)D levels were present in 67.2-73.0% of patients [22,57,60], and ranged from 13.5 to 16.9 ng/mL. Prakash et al examined 71 patients with chronic TTH, and found significantly lower mean 25(OH)D serum levels in subjects with musculoskeletal pain coexisting with headache comparing to those with headache only [22].…”

Section: Vitamin D Deficiency and Tension-type Headachesmentioning

confidence: 99%

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The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment

et al. 2020

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Some studies have suggested a link between vitamin D and headache; however, the underlying physiological mechanisms are unclear. We aimed to summarize the available evidence on the relationship between vitamin D and the various subtypes of primary headaches, including migraines and tension-type headaches. All articles concerning the association between primary headache and vitamin D published up to October 2019 were retrieved by searching clinical databases, including: EMBASE, MEDLINE, PubMed, Google scholar, and the Cochrane library. All types of studies (i.e., observational, cross-sectional, case-control, and clinical trials) were included. We identified 22 studies investigating serum vitamin D levels in association with headaches. Eight studies also evaluated the effect of vitamin D supplementation on the various headache parameters. Among them, 18 studies showed a link between serum vitamin D levels and headaches, with the strongest connection reported between serum vitamin D levels and migraine. Overall, there is not enough evidence to recommend vitamin D supplementation to all headache patients, but the current literature indicates that it may be beneficial in some patients suffering headaches, mainly migraineurs, to reduce the frequency of headaches, especially in those with vitamin D deficiency.

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Chronic Daily Headache Classification

Waung

Levin

2018

Chronic Headache

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Vitamin D Deficiency in Patients With Chronic Tension‐Type Headache: A Case‐Control Study

Abstract: Decreased serum 25(OHD) concentration was associated with CTTH. Intervention studies are required to find out if supplementation of vitamin D is effective in patients with CTTH.

Cited by 35 publications

References 37 publications

Adverse Childhood Experiences (ACEs) and Headaches Among Children: A Cross‐Sectional Analysis

Adverse Childhood Experiences (ACEs) and Headaches Among Children: A Cross‐Sectional Analysis

The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment

Chronic Daily Headache Classification

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