Vitamin D deficiency in pregnant women

Chen, Bo; Chen, Yong Q.; Xu, Yuanhong

doi:10.1097/md.0000000000027505

Cited by 20 publications

(12 citation statements)

References 27 publications

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“…Regarding maternal characteristics in this study, the mean age of mothers in all the studied neonates was > than 20 y while in Fernandes et al, the age of 84.6% of mothers was ≥ 20 years [ 8 ]. On the other hand, maternal age of neonates with IUGR was statistically significantly less than that of AGA neonates (25.29 ± 4.55 years) in the study done by Chen et al, [ 35 ] which disagrees with our study as we didn’t detect any significant difference between mothers with IUGR neonates and those with AGA. The study done by Mohammad et al reported that young (25.8 ± 2.1 years) age of the mother was risk factor for intrauterine growth restriction [ 36 ], which disagrees also with our results.…”

Section: Discussioncontrasting

confidence: 99%

Assessment of vitamin status; A, E and D in Egyptian neonates with IUGR: a cross sectional study

Abdallah,

Abdelrazek,

Youness

et al. 2024

BMC Pediatr

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Background Neonates with intrauterine growth retardation (IUGR) may present with fatal complications and permanent serious consequences. Vitamin status may influence fetal development. In this study we assessed vitamin A, E and D concentrations in umbilical cord blood in newborns with IUGR. Methods Maternal data were obtained. Neonatal assessment included; age of gestation calculated from last menstrual period, Ultrasound (U/S), new Ballard, Apgar scores and anthropometric measurements including; Head circumference, length and weight. WHO growth percentile curves were used. Vitamin A, E and D in cord blood samples were measured by high performance liquid chromatography (HPLC) and ELISA consecutively. Results A total of 86 full term newborns were enrolled in this study, 42 (48.8%) with IUGR with gestational age (33.59 ± 1.20) week by U/S and 44 (51.2%) appropriate for gestational age neonates with gestational age (38.70 ± 1.50). Ballard and Apgar scores (p < 0.05) and Z scores for weight, length and head circumference (p < 0.001) at birth were significantly lower in neonates with Intrauterine growth retardation (IUGR) than appropriate for gestational age (AGA) neonates. The levels of Vitamin A, E and D were significantly lower in the IUGR group than the AGA (p < 0.05) for all. Significant positive correlations of weight with vitamin A, and E cord blood levels were found (p < 0.05), while length was significantly positively correlated only with vitamin A (p < 0.05). Head circumference showed significant positive correlations with the three vitamins (p < 0.05) for all. Conclusion Neonates with IUGR had significantly lower levels of Vitamin A, E and D than AGA neonates. Significant positive correlations of weight with vitamin A, and E cord blood levels was detected, while neonatal length was associated only with vitamin A level. The present study highlights the significance of nutritional policies for inhibiting deficiency of these vitamins during pregnancy and childhood.

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Section: Discussioncontrasting

confidence: 99%

Assessment of vitamin status; A, E and D in Egyptian neonates with IUGR: a cross sectional study

Abdallah,

Abdelrazek,

Youness

et al. 2024

BMC Pediatr

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“…This Meta-analysis incorporated 13 cohort studies, all of which received high quality scores. The findings of the Meta-analysis indicated that there was no significant difference in the incidence of preterm birth among newborns born to pregnant mothers in the vitamin D deficient group compared to those in the adequacy group, consistent with previous literature conclusions ( 15 , 17 – 22 ). The findings of previous studies in the literature ( 14 , 15 , 17 , 18 , 20 , 21 , 23 ) suggest that there is no significant correlation between maternal vitamin D levels during pregnancy and the occurrence of SGA infants, which aligns with the results of the current study.…”

Section: Discussionsupporting

confidence: 89%

“…The findings of previous studies in the literature ( 14 , 15 , 17 , 18 , 20 , 21 , 23 ) suggest that there is no significant correlation between maternal vitamin D levels during pregnancy and the occurrence of SGA infants, which aligns with the results of the current study. However, for the outcome of low birth weight infants (LBWI), the incidence was greater in the group with vitamin D deficiency during pregnancy, consistent with existing literature ( 16 , 22 , 24 , 26 ) but conflicting with the findings of A Rodriguez et al ( 14 , 15 , 17 , 18 , 20 , 21 ).…”

Section: Discussionsupporting

confidence: 56%

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The effect of vitamin D deficiency during pregnancy on adverse birth outcomes in neonates: a systematic review and meta-analysis

You,

Mei,

Zhang

et al. 2024

Front. Pediatr.

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ObjectiveTo systematically evaluate the effect of vitamin D deficiency during pregnancy on neonatal adverse outcomes, such as preterm infants, low birth weight infants (LBWI), and small for gestational age (SGA) infants.MethodsA comprehensive literature search was conducted across multiple databases including PubMed, Embase, Cochrane Library, SinoMed, Wanfang Data Knowledge Service Platform, China National Knowledge Internet (CNKI), and VIP Chinese Science and Technology Journal Database (VIP). Following predefined inclusion and exclusion criteria, two researchers independently screened, extracted data, and assessed the quality of the included studies. Meta-analysis was performed using RevMan 5.4 and Stata 14 software to synthesize the findings.ResultsThis study incorporated 13 cohort studies from 8 different countries and regions, encompassing a total of 55,162 pregnant women, among whom 28,155 were identified as having vitamin D deficiency. The Newcastle-Ottawa Scale (NOS) score ranged from 7–9 points. Meta-analysis results indicated a higher incidence of LBWI (OR = 5.52, 95% CI = 1.31–23.22. P = 0.02) in the group of pregnant women with vitamin D deficiency compared to those with adequate levels. However, there was no statistically significant difference in the likelihood of premature birth (OR = 1.25, 95% CI = 0.78–1.99. P = 0.36) or SGA (OR = 1.47, 95% CI = 0.81–2.68. P = 0.21) among newborns born to mothers with vitamin D deficiency vs. those with sufficient levels of vitamin D. Subgroup analysis based on the timing of maternal blood collection revealed that there was no statistically significant association between vitamin D levels during pregnancy and the incidence of preterm birth across all stages of pregnancy. Furthermore, vitamin D deficiency throughout the entire pregnancy was associated with an increased incidence of neonatal LBWI, whereas vitamin D levels during the first, second, and third trimesters did not demonstrate statistically differences on LBWI. Neonates born to mothers with vitamin D deficiency throughout pregnancy were found to have a higher likelihood of developing SGA. However, there was no statistically significant association between vitamin D levels and the development of SGA during the first and second trimesters.ConclusionsAdequate levels of vitamin D during pregnancy may decrease the incidence of LBWI, although further research is needed to determine its impact on the occurrence of preterm birth and SGA.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024535950, Identifier: (CRD42024535950).

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“…Several gestational complications, such as gestational diabetes, gestational hypertension, premature rupture of membranes, and premature delivery may occur due to vitamin D deficiency. [11] Vitamin D also plays a crucial role in pelvic floor muscle functions. Several studies have demonstrated that vitamin D deficiency is associated with UI in nonpregnant women.…”

Section: Introductionmentioning

confidence: 99%

The effect of vitamin D deficiency on urinary incontinence during third trimester pregnancy

Gul,

Aydogmus,

Keles

et al. 2023

Medicine

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Urinary incontinence (UI) is a common problem which is associated with impaired quality of life. Vitamin D plays a crucial role for pelvic floor muscle function. The aim of this study was to investigate the effect of vitamin D deficiency on UI in pregnant women in the third trimester of pregnancy. All pregnant women at > 28 weeks of gestation who were followed in the gynecology and obstetrics outpatient clinic were screened. The patients were assessed for UI during routine follow-up. The Incontinence Severity Index was used to determine the severity of UI. A total of 210 patients were included as the study group and 40 patients were included as the control group. Both groups were compared based on the International Incontinence Severity Index scores. Of the patients, 40% had a history of UI and 84% had vitamin D deficiency. Pregnant women with vitamin D deficiency had statistically significant UI, compared to pregnant women in the control group. The severity of UI was also significantly higher in the patients with vitamin D deficiency. Urinary incontinence is significantly associated with vitamin D deficiency in pregnant women.

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Vitamin D deficiency in pregnant women

Cited by 20 publications

References 27 publications

Assessment of vitamin status; A, E and D in Egyptian neonates with IUGR: a cross sectional study

Assessment of vitamin status; A, E and D in Egyptian neonates with IUGR: a cross sectional study

The effect of vitamin D deficiency during pregnancy on adverse birth outcomes in neonates: a systematic review and meta-analysis

The effect of vitamin D deficiency on urinary incontinence during third trimester pregnancy

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