Vitamin D Deficiency Is Associated with Severity of Dry Eye Symptoms and Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis

Kuo, Che Yuan; Huang, Yu Chen; Lin, Ko Jo; Tsai, Tsung Yu

doi:10.3177/jnsv.66.386

Cited by 23 publications

(14 citation statements)

References 8 publications

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“…The results of the present meta-analysis, based on a statistical analysis of the results of nine studies, show that vitamin D levels are generally lower in SD patients compared with healthy controls, but with a significant overall heterogeneity, indicating several confounding factors. Similar results were observed in the meta-analysis by Kuo et al [ 29 ]. On the other hand, Li et al previously reported comparable serum vitamin D levels between SD patients and controls [ 14 ].…”

Section: Discussionsupporting

confidence: 91%

Vitamin D and Sjögren’s Disease: Revealing the Connections—A Systematic Review and Meta-Analysis

et al. 2023

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Background: The aim of the present review was to summarize the current evidence about the impact of vitamin D deficiency on pathology and clinical manifestations of Sjögren’s disease (SD). Methods: Databases PubMed, Web of Science, Scopus, and Cochrane library were searched for studies assessing the levels of vitamin D in SD patients using the following keywords: (vitamin D OR calciferol OR cholecalciferol OR 25-hydroxyvitamin D OR 25-hydroxycholecalciferol OR calcidiol OR calcitriol OR 1,25-dihydroxycholecalciferol) AND (Sjögren’s Syndrome OR Sjögren’s disease) accessed on 20 September 2022. Out of 248 retrieved studies, following the systematic review methodology and defined inclusion and exclusion criteria, 9 clinical studies were eligible to be included in the present review: 4 of them case-control, 4 cross-sectional, and 1 cohort study. Results: Nine studies totaling 670 SD patients and 857 healthy controls were eligible for meta-analysis with moderate to high methodological quality as determined by the Newcastle–Ottawa Quality Scale (NOS). According to the obtained results, a high prevalence of hypovitaminosis D was observed in SD patients when compared to healthy controls (95% CI −10.43, −2.39; p < 0.01). Conclusion: Available evidence points to lower levels of vitamin D in patients with SD in comparison to healthy controls. However, further studies are necessary to understand the underlying mechanisms associated with the role of vitamin D in the development and disease severity of SD.

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Section: Discussionsupporting

confidence: 91%

Vitamin D and Sjögren’s Disease: Revealing the Connections—A Systematic Review and Meta-Analysis

et al. 2023

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“…Vitamin D may intervene in SS pathogenesis, influencing the presence of extra-glandular symptoms such as lymphoma or neuropathy [ 345 ]. One meta-analysis, including 18 studies with SS patients, concluded that patients with vitamin D deficiency associated higher severity scores of dry eye symptoms, such as lower Schirmer’s test scores and higher ocular surface disease index (OSDI) scores [ 214 , 346 ].…”

Section: Vitamin D and Immune-related And Autoimmune Diseasesmentioning

confidence: 99%

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

Simu

Rednic

Grama

et al. 2022

IJMS

120

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Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis. Experimental studies have shown that 1,25-dihydroxyvitamin D (calcitriol) generates immunologic activities on the innate and adaptive immune system and endothelial membrane stability. Low levels of serum 25-hydroxyvitamin D (25(OH)D) are associated with an increased risk of developing immune-related diseases such as psoriasis, type 1 diabetes, multiple sclerosis, and autoimmune diseases. Various clinical trials describe the efficacy of supplementation of vitamin D and its metabolites for treating these diseases that result in variable outcomes. Different disease outcomes are observed in treatment with vitamin D as high inter-individual difference is present with complex gene expression in human peripheral blood mononuclear cells. However, it is still not fully known what level of serum 25(OH)D is needed. The current recommendation is to increase vitamin D intake and have enough sunlight exposure to have serum 25(OH)D at a level of 30 ng/mL (75 nmol/L) and better at 40–60 ng/mL (100–150 nmol/L) to obtain the optimal health benefits of vitamin D.

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“…2023; 3:307 4 inmunitaria y presenta disociación clínica, debido que no se manifiesta clínicamente sino cuando los niveles se encuentran relativamente bajos. (20) Se demuestra que la exposición solar es un factor importante en la presencia de vitamina de D, debido que las exacerbaciones de enfermedades autoinmunes como la esclerosis múltiple se da en primavera, incluso al suplementar vitamina D reduce un 40 % de riesgo; (21) se evidenció el mismo en prevenir el desarrollo de AR. (22,23) Por otra parte, el déficit de vitamina D se asociada a espondiloartopatías, por el contrario, Chen M et al (15) reportaron correlación negativa entre los niveles séricos de Vitamina D y espondiloartopatías.…”

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Role of vitamin D in autoimmune rheumatological diseases

Centeno

Aguinsaca

Yunga

et al. 2023

Salud, Ciencia y Tecnología

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Introduction: Vitamin D is a hormone synthesized in the skin, by the presence of the "precursor molecule 7-dehicrocholesterol" whose action depends directly on the stimulus of ultraviolet rays for the production of cholecalciferol. It has several functions including a fundamental role in mediating the response of the immune system, plays modulatory actions, counteracts inflammatory, oxidative and fibrotic activity, and consequently regulates autoimmune tissue lesions. As it possesses an immunomodulatory property, is related to the appearance and progression of autoimmune disorders. Objective: To describe the role of vitamin D in autoimmune rheumatologic diseases. Methods: A narrative review was performed, collecting information from January 2019 to January 2023 in scientific databases such as: Pubmed, Scopus, Web of Science, and Google Scholar, using keywords. Results: Vitamin D in autoimmune rheumatic diseases influences the control and decrease of inflammatory activity, slows its speed of progression and improves clinical manifestations, although there is no total consensus on the mode of use, however, its supplementation has a great benefit. Conclusions: The role of Vitamin D in autoimmune rheumatic diseases varies according to the underlying pathology, in combination with bisphosphonates it can improve bone mineral density in spondyloarthropathies, prevent osteoporosis, improve the clinical picture of SLE and Systemic Sclerosis, but it can increase antibody levels in Connective Tissue Diseases.

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Vitamin D Deficiency Is Associated with Severity of Dry Eye Symptoms and Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis

Cited by 23 publications

References 8 publications

Vitamin D and Sjögren’s Disease: Revealing the Connections—A Systematic Review and Meta-Analysis

Vitamin D and Sjögren’s Disease: Revealing the Connections—A Systematic Review and Meta-Analysis

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

Role of vitamin D in autoimmune rheumatological diseases

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