Vitamin-D deficiency predicts infections in young north Indian children: A secondary data analysis

Chowdhury, Ranadip; Taneja, Sunita; Bhandari, Nita; Sinha, Bireshwar; Upadhyay, Ravi Prakash; Bhan, Maharaj Kishan; Strand, Tor A.

doi:10.1371/journal.pone.0170509

Cited by 33 publications

(28 citation statements)

References 50 publications

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“…For instance, while soft substrates (0.6 kPa polyacrylamide gels coated with of type-1 collagen) sustain embryonic stem cell (ESC) self-renewal [94], rigid/stiff substrates induce differentiation/lineage specification of mesenchymal stem cells (MSCs) [95]. ECM structure also impacts on tumor cells' behavior.…”

Section: Vitc-dependent Regulation Of Ecm/collagen Homeostasismentioning

confidence: 99%

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

D’Aniello

Cermola

Patriarca

et al. 2017

Stem Cells International

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Transcription factors and signaling molecules are well-known regulators of stem cell identity and behavior; however, increasing evidence indicates that environmental cues contribute to this complex network of stimuli, acting as crucial determinants of stem cell fate. l-Ascorbic acid (vitamin C (VitC)) has gained growing interest for its multiple functions and mechanisms of action, contributing to the homeostasis of normal tissues and organs as well as to tissue regeneration. Here, we review the main functions of VitC and its effects on stem cells, focusing on its activity as cofactor of Fe+2/αKG dioxygenases, which regulate the epigenetic signatures, the redox status, and the extracellular matrix (ECM) composition, depending on the enzymes' subcellular localization. Acting as cofactor of collagen prolyl hydroxylases in the endoplasmic reticulum, VitC regulates ECM/collagen homeostasis and plays a key role in the differentiation of mesenchymal stem cells towards osteoblasts, chondrocytes, and tendons. In the nucleus, VitC enhances the activity of DNA and histone demethylases, improving somatic cell reprogramming and pushing embryonic stem cell towards the naive pluripotent state. The broad spectrum of actions of VitC highlights its relevance for stem cell biology in both physiology and disease.

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Section: Vitc-dependent Regulation Of Ecm/collagen Homeostasismentioning

confidence: 99%

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

D’Aniello

Cermola

Patriarca

et al. 2017

Stem Cells International

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“…These studies which included various age groups reflect the magnitude of the problem. High prevalence was seen throughout the country[ 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 ] [ Table 2 ].…”

Section: Magnitude Of Vitamin D Deficiency In Indiamentioning

confidence: 99%

Vitamin D deficiency in India

Aparna

Nongkynrih

et al. 2018

J Family Med Prim Care

185

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Vitamin D is a fat-soluble vitamin playing a vital role in human physiology. Vitamin D deficiency is prevalent worldwide. This deficiency has many consequences which are still being explored, apart from the well-known skeletal complications. With this review, we aim to summarize the existing literature on Vitamin D status in India and understand the enormity of the problem. The prevalence of Vitamin D deficiency ranged from 40% to 99%, with most of the studies reporting a prevalence of 80%–90%. It was prevalent in all the age groups and high-risk groups alike. With the consequences of Vitamin D deficiency, namely, autoimmune diseases, cardiovascular diseases, cancer, and tuberculosis being explored, we can imagine the burden it would cause in our country. We need to create awareness among the public and healthcare providers about the importance of Vitamin D and the consequences of deficiency. Our Indian diet generally fails to satisfy the daily requirement of Vitamin D for a normal adult. This stresses on the need for fortifying various food with Vitamin D, through the national programs. This silent epidemic should be addressed appropriately with concrete public health action.

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“…Furthermore, the predictive ability of early neurodevelopmental assessments is poor, and cognitive assessments in school-aged children have shown to be stable over time [14,15]. We measured vitamin D status in 1000 young North Indian children and conducted a comprehensive assessment of cognitive performance and growth approximately 6 years later [16,17]. This study gave us a unique opportunity to explore the extent to which vitamin D deficiency during early childhood is associated with impaired cognitive development and linear growth at school age.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status in early childhood is not associated with cognitive development and linear growth at 6–9 years of age in North Indian children: a cohort study

Chowdhury

Taneja

Kvestad

et al. 2020

Nutr J

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Background: Vitamin D is important for brain function and linear growth. Vitamin D deficiency during pregnancy has been linked with impaired neurodevelopment during early childhood. However, there is limited evidence from population-based studies on the long-term impact of vitamin D deficiency on cognitive development and linear growth. The objective of the current analysis is to examine whether vitamin D deficiency during infancy and early childhood is associated with cognitive development and linear growth measured in school age. Methods: This is a follow-up study of a placebo-controlled trial among 1000 North Indian children 6-30 months of age. We measured growth and neurodevelopment in 791 of these children when they were 6-9 years old. Neurodevelopment was measured using the Wechsler Intelligence Scale for Children, 4th edition INDIA , the Crichton Verbal Scale, NEPSY-II subtests, and the BRIEF 2. We categorized vitamin D concentrations during infancy and early childhood according to the US Institute of Medicine's recommendations; serum 25(OH)D < 12 ng/ml as deficient; 12-20 ng/ml as inadequate; > 20 ng/ml as sufficient. In multivariable regression models, adjusting for relevant confounders, we estimated the association between vitamin D status, growth and neurodevelopmental outcomes.Results: Among the 791 children, baseline vitamin D status was available for 716. Of these, 45.8% were vitamin D deficient, 32.7% were inadequate, and 21.5% were sufficient. Vitamin D status was not associated with any of the cognitive outcomes or linear growth [Adjusted β coefficient for height for age z-score between deficient and sufficient children was − 0.06 (95% CI − 0.24 to 0.11)] at follow up.

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Vitamin-D deficiency predicts infections in young north Indian children: A secondary data analysis

Cited by 33 publications

References 50 publications

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

Vitamin D deficiency in India

Vitamin D status in early childhood is not associated with cognitive development and linear growth at 6–9 years of age in North Indian children: a cohort study

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