2007
DOI: 10.1056/nejmra070553
|View full text |Cite
|
Sign up to set email alerts
|

Vitamin D Deficiency

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

188
13,240
46
799

Year Published

2009
2009
2016
2016

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 12,553 publications
(14,273 citation statements)
references
References 114 publications
188
13,240
46
799
Order By: Relevance
“…In humans, vitamin D deficiency generally is defined as a serum 25(OH)D concentration of <50 nmol/L. Serum concentrations below this concentration are associated with an increase in serum parathyroid hormone concentrations, which were not evaluated in the present study 1, 23. Fourthly, invasive gold standard tests of cardiac function, such as left ventricular d P /d t and τ, were not determined in the present study.…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…In humans, vitamin D deficiency generally is defined as a serum 25(OH)D concentration of <50 nmol/L. Serum concentrations below this concentration are associated with an increase in serum parathyroid hormone concentrations, which were not evaluated in the present study 1, 23. Fourthly, invasive gold standard tests of cardiac function, such as left ventricular d P /d t and τ, were not determined in the present study.…”
Section: Discussionmentioning
confidence: 96%
“…Firstly, it was a cross‐sectional study, and therefore our findings do not prove causality between vitamin D status in each of various stages of disease and cardiac remodeling. Secondly, vitamin D metabolism was not investigated, and the mechanisms involved in the decrease in serum 25(OH)D concentrations (eg, decreased intake, hepatic synthetic dysfunction, renal loss) were not determined 23. In particular, the vitamin D intake in enrolled dogs was not determined, although the calculated vitamin D intake in dogs with congestive heart failure was not significantly different from that of healthy dogs in a previous study 10.…”
Section: Discussionmentioning
confidence: 98%
“…Serum parathyroid hormone activity, for example, has been established as a marker in human populations in whom increases in parathyroid hormone serve as an indicator of 25(OH)D insufficiency 43. In people, the inverse relationship between parathyroid hormone and vitamin D concentrations is used to define both vitamin D inadequacy and target serum concentrations of vitamin D necessitating supplementation 44. Efforts to define a similar relationship between parathyroid hormone and vitamin D in dogs should be considered.…”
Section: Discussionmentioning
confidence: 99%
“…The source, distribution and specific immunomodulating effects of VD3 are less well understood. In addition to nutritional uptake of cholecalciferol, precursors can also be formed in superficial skin layers when UVB irradiation and spontaneous isomerization non‐enzymatically convert 7‐dehydro‐cholesterol to VD3 8. However, VD3 does not efficiently bind the intracellular receptor vitamin D receptor (VDR).…”
mentioning
confidence: 99%
“…In spite of the generation of VD3 from sun exposed skin, VD3 bioavailability may be insufficient as the result of habits of sun avoidance or protection and concomitantly insufficient nutritional uptake. An estimated 40–100% of US or European elderly and 1 billion people worldwide do not have sufficient VD3 levels 8. Although severe complications of childhood VD3 deficiency, most notably rickets, are rarely seen nowadays in countries with western lifestyle, the epidemiological associations of autoimmune diseases with VD3 insufficiency point to the importance of a mechanistic understanding of the interactions of the immune system and VD3 8, 9.…”
mentioning
confidence: 99%