Vitamin D: does it help Tregs in active rheumatoid arthritis patients

El-Banna, Hanaa Samy; Gado, Souzan Ezzat

doi:10.1080/1744666x.2020.1805317

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…These are also used to elevate the function of IL-4, IL-5, and IL-10, as well as the total antioxidant capacity, repair the balance between Th1/Th2 cells and stabilize Treg cells that release several regulatory mediators in inflammation like transforming growth factor (TGF)-β. (23,24) Our findings are similar to what was presented in earlier research; 41.2% of subjects with RA suffered from vitamin D deficiency, which was classified as ≤20 ng/ mL. (25,26) Those with Indonesian ethnicity tend to have darker skin and higher melanin content that inhibits the skin synthesis of vitamin D, compared to East Asian or European people.…”

Section: Discussionsupporting

confidence: 88%

Seluang Fish (Rasbora sp.) Oil Improves Interleukin-17 Levels and Disease Activity in Rheumatoid Arthritis

Partan¹,

Mikhael²,

Adinata³

et al. 2023

Indones Biomed J

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BACKGROUND: Vitamin D has a role in downregulating the proinflammatory cytokines as well as promoting the antiinflammatory pathway in rheumatoid arthritis (RA). Seluang fish (Rasbora sp.) has potency as a new source of vitamin D. Previous study had proven Seluang fish oil efficacy in systemic lupus erythematosus. However, there are no trials that prove its efficacy in RA yet. Hence, this study was conducted to find out the ability of Seluang fish oil to improve proinflammatory cytokines, vitamin D levels, and disease activity in RA.METHODS: A clinical trial with a randomized and double-blind method was done in two groups, each one consisting of 17 RA subjects. One group was given 500 mL of a Seluang fish oil capsule (contains 665 IU cholecalciferol), while the other group was given a placebo daily, for 12 consecutive weeks. Measurements of the RA disease activity score 28 erythrocyte sedimentation rate (DAS28-ESR) and DAS28 C-reactive protein (DAS28-CRP), as well as measurement of interleukin (IL)-6, IL-17, and vitamin D levels by using immunoassay method were performed before and after the supplementation.RESULTS: Significant alterations in the lower levels of IL-17 were observed in the Seluang fish oil group (p=0.031), but not in the placebo group (p=0.320). Reduction of DAS28-ESR (p=0.000) and DAS28-CRP (p=0.000) score demonstrated that the Seluang fish oil supplementation was useful in reducing RA disease activity. No significant shift was observed in either vitamin D (p=0.967) or IL-6 levels (p=0.076) after Seluang Fish Oil supplementation.CONCLUSION: Seluang fish oil is effective in lowering IL-17 levels, DAS28-ESR, and DAS28-CRP, but not in improving vitamin D level or lowering IL-6 level in RA patients.KEYWORDS: rheumatoid arthritis, seluang fish oil, interleukin-6, interleukin-17, vitamin D, DAS28

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Section: Discussionsupporting

confidence: 88%

Seluang Fish (Rasbora sp.) Oil Improves Interleukin-17 Levels and Disease Activity in Rheumatoid Arthritis

Partan¹,

Mikhael²,

Adinata³

et al. 2023

Indones Biomed J

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“…Importantly, this type of regimen is of key interest in many chronic diseases. Recent studies have shown encouraging results in patients with CP after nutritional interventions (7,(14)(15)(16)(17)(18) thanks to decreased intestinal barrier permeability as the result of lower pro-inflammatory mediator production, thereby preventing the passage of certain metabolites into the bloodstream (19,20). In addition, the consumption of anti-inflammatory foods seemed to improve patient quality of life (QoL) by decreasing their levels of stress, anxiety, depression, and cognitive and sleep disturbances (21), achieved by reducing inflammation and oxidative stress (22).…”

Section: Introductionmentioning

confidence: 99%

The effect of an anti-inflammatory diet on chronic pain: a pilot study

et al. 2023

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ObjectiveRheumatic diseases result in chronic pain (CP) and require treatment with drugs whose prolonged administration is associated with side effects. However, publications in the academic literature have suggested that diet modification and food supplementation can play a crucial role in alleviating the symptoms of inflammatory disease. Thus, it is hoped that the use of an anti-inflammatory diet for pain management might result in improved quality of life. Hence, here we aimed to investigate the effect of anti-inflammatory foods in patients with CP caused by rheumatic diseases.MethodsAfter an exhaustive bibliography search, we designed a 13-item anti-inflammatory dietary guide based on a Mediterranean diet without red meat, gluten, or cow’s milk (the AnMeD-S). We then conducted a pilot study to evaluate the efficacy of this anti-inflammatory diet in patients with CP. A food consumption score (with a maximum of 156 points) was then applied to evaluate patient adhesion to the proposed diet. Forty-five patients with CP were followed-up for 4 months. Variables related with quality of life (including pain perception, depression status, and sleep satisfaction) were measured using 9 validated questionnaires and anthropometric measurements were recorded before and after the participants followed the anti-inflammatory diet.ResultsWe found a correlation between increased anti-inflammatory food intake and improved physical characteristics, stress, and pain in the patients we assessed. Moreover, decreased consumption of pro-inflammatory foods was positively correlated with sleep satisfaction. Following the AnMeD-S was associated with improved physical characteristics and quality-of-life in patients with CP.ConclusionThe AnMeD-S, includes anti-inflammatory foods and restricts the consumption of certain pro-inflammatory foods (such as those containing gluten). This dietary pattern could provide relief from CP and improve the symptoms of stress and depression, as well as reducing sleep disturbances.

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“…Vitamin D is a steroid hormone that regulates calcium homeostasis and skeletal health ( Chang et al, 2021 ). Some evidence suggests that vitamin D is an immunomodulatory hormone with an established role in bone mineralisation ( El-Banna and Gado, 2020 ; Verma et al, 2021 ). In a large-scale vitamin D and omega-3 trial (VITAL) that lasted approximately 5 years, the impact of supplementation with vitamins and omega-3 fatty acids on autoimmune disease rates, including rheumatoid arthritis, polymyalgia rheumatic, autoimmune thyroiditis and psoriatic arthritis, was reported.…”

Section: Introductionmentioning

confidence: 99%

“…The placebo group included 155 participants who confirmed autoimmune diseases (hazard ratio 0.78%, 95% confidence interval 0.61 to 0.99, p = 0.05) ( Hahn et al, 2022 ). A trial of 40 patients with active RA showed that vitamin D supplementation for 3 months can increase regulatory T cells, reduce Disease Activity Score-28 scores and modulate the immune system ( El-Banna and Gado, 2020 ). Another study showed that vitamin D deficiency was associated with a 72.6% higher prevalence of new fractures in Japanese women over 50 with rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

Detecting potential mechanism of vitamin D in treating rheumatoid arthritis based on network pharmacology and molecular docking

Luo

Chen

et al. 2022

Front. Pharmacol.

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Aim: Vitamin D plays a vital role in Rheumatoid arthritis (RA). However, the mechanism of vitamin D and rheumatism is still unclear. Therefore, a strategy based on network pharmacology and molecular docking was used to explore the mechanism of vitamin D and RA.Methods: The targets of RA were obtained from the GeneCards database and Therapeutic Targets Database, and the targets of vitamin D were obtained from the Drugbank database and STITCH database. Next, overlapping genes were identified by Venny, and further Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and molecular docking analyses were performed.Results: A total of 1,139 targets of RA and 201 targets of vitamin D were obtained. A total of 76 overlapping genes were identified by Venny. The enrichment analysis showed that cell proliferation, immune response, and apoptotic process were the critical biological processes of vitamin D in treating RA. Antifolate resistance, osteoclast differentiation, and the nuclear factor-kappa B (NF-κB) signalling pathway are fundamental mechanisms of vitamin D in treating RA. According to further molecular docking, ALB, TNF, CASP3, and TP53 may be important punctuation points or diagnostic markers for future RA treatment.Conclusion: By analysing overlapping genes of diseases and drugs, this study confirmed that ALB, TNF, CASP3, and TP53 may be essential markers or diagnostic markers for future RA treatment.

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Vitamin D: does it help Tregs in active rheumatoid arthritis patients

Cited by 7 publications

References 34 publications

Seluang Fish (Rasbora sp.) Oil Improves Interleukin-17 Levels and Disease Activity in Rheumatoid Arthritis

Seluang Fish (Rasbora sp.) Oil Improves Interleukin-17 Levels and Disease Activity in Rheumatoid Arthritis

The effect of an anti-inflammatory diet on chronic pain: a pilot study

Detecting potential mechanism of vitamin D in treating rheumatoid arthritis based on network pharmacology and molecular docking

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