Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Abstract

OBJECTIVE:To evaluate the potential role of vitamin D on ovarian reserve markers in infertile women with different reserve patterns. STUDY DESIGN:This prospective cross-sectional study included the infertile women attending the Hitit University Hospital. The initial examination included the measurements of waist circumference and hip circumference, body mass index, and waist/hip ratio. A total of 171 women were divided into three groups according to ovarian reserve patterns: (i) adequate ovarian reserve pattern (AOR, n=77), (ii) high ovarian reserve pattern (polycystic ovarian syndrome, n=62), and (iii) diminished ovarian reserve pattern (DOR, n=32). The serum estradiol (E2), follicle stimulating hormone, total testosterone, 17-hydroxyprogesterone (17 (OH) P), dehydroepiandrosterone sulfate, anti-mullerian hormone, and hydroxycholecalciferol (25 (OH) D) levels were analyzed. RESULTS:No significant difference between three different groups was detected in terms of body mass index, waist circumference, hip circumference, waist/hip ratio, E2 and 17OHP levels (p>0.05, for all). One-hundred-sixty-nine (98.2%) women in all groups had vitamin D concentration below 30 ng/mL as a cut-off value. The circulating 25 (OH) D levels did not show a significant difference between all ovarian reserve groups (p=0.804). No correlation between 25 (OH) D and anti-mullerian hormone levels was documented in women with AOR, polycystic ovarian syndrome and DOR patterns (r=-0.099 p=0.393, r=0.034 p=0.794 and r=0.157 p=0.390 respectively). 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group (r=-0.355 p=0.002, r=-0.305 p=0.007 and r=-0.322 p=0.004 respectively). CONCLUSIONS:There is no association between 25 (OH) D and ovarian reserve markers. 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group.

Is There a Relationship Between Vitamin D Deficiency Status and PCOS in Infertile Women?

“…Another study proposed that vitamin D receptor polymorphism could play a part in the pathogenesis of PCOS 18 . However, several other studies claim that vitamin D does not have any impact on ovarian reserve markers 19 , 20 . It is therefore still unclear whether low vitamin D levels play a role in the pathogenesis of PCOS, especially in AMH regulation.…”

A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

“…The mechanism by which vitamin D may affect AMH and FSH is unclear. Similar to human studies, the findings of experimental studies regarding this association are also inconclusive 66 – 68 . Vitamin D may influence ovarian steroidogenesis, development of the follicles, and ovarian reserve 7 .…”

The association between vitamin D/25(OH)D and reproductive hormone in young women with recurrent aphthous stomatitis: An observational study

“…On the contrary, a study showed that there was not a significant correlation between vitamin D/25(OH)D with LH but there was a positive correlation between vitamin D/25(OH)D with FSH in women with adequate ovarium reserve pattern. [40] Other study did not show any correlation between vitamin D/25(OD) and FSH and LH in nonobese, overweight, and obese women. [41] However, other study showed different results that revealed that vitamin D/25(OH)D has an inverse correlation with FSH.…”