Vitamin D for Recovery of COVID-19 in Patients With Chronic Kidney Disease

Chiang, Wei Fan; Hsiao, Po-Jen; Chan, Jenq-Shyong

doi:10.3389/fnut.2022.930176

Cited by 5 publications

(4 citation statements)

References 94 publications

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“…Vitamin D deficiency is seen in most patients suffering from CKD; its deficiency can affect the COVID-19 outcome. Vitamin D influences innate and adaptive immunity, which influences how the immune system reacts to viruses and bacteria [ 198 ]. According to previous research, even a short-term acute vitamin D shortage can cause hypertension and affect the parts of the renin-angiotensin system that cause kidney damage.…”

Section: Therapeutic Management Of Renal Disorder Patients With Covid-19mentioning

confidence: 99%

Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches

et al. 2023

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a respiratory disorder. Various organ injuries have been reported in response to this virus, including kidney injury and, in particular, kidney tubular injury. It has been discovered that infection with the virus does not only cause new kidney disease but also increases treatment difficulty and mortality rates in people with kidney diseases. In individuals hospitalized with COVID-19, urinary metabolites from several metabolic pathways are used to distinguish between patients with acute kidney injury (AKI) and those without. This review summarizes the pathogenesis, pathophysiology, treatment strategies, and role of metabolomics in relation to AKI in COVID-19 patients. Metabolomics is likely to play a greater role in predicting outcomes for patients with kidney disease and COVID-19 with varying levels of severity in the near future as data on metabolic profiles expand rapidly. Here, we also discuss the correlation between COVID-19 and kidney diseases and the available metabolomics approaches.

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Section: Therapeutic Management Of Renal Disorder Patients With Covid-19mentioning

confidence: 99%

Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches

et al. 2023

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“…Vitamin D has been reported to protect against infectious diseases, including SARS-CoV-2 infection [11]. Recent studies have reported that lower serum 25-hydroxyvitamin D (25OHD) level is a risk factor for severity and mortality in COVID-19 [12,13].…”

Section: Introductionmentioning

confidence: 99%

Active vitamin D analog and SARS‐CoV‐2 IgG after BNT162b2 vaccination in patients with hemodialysis

Nakashima,

Yamamoto,

Kobayashi

et al. 2024

Ther Apher Dial

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IntroductionVaccination is the effective strategy for coronavirus disease 2019 (COVID‐19). However, few studies have investigated the association between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) immunoglobulin (Ig)G and vitamin D.MethodsThis study aimed to investigate the association between SARS‐CoV‐2 IgG and active vitamin D analogs in hemodialysis patients. Blood samples were collected four times: before vaccination and 30, 60, and 90 days after vaccination, BNT162b2 (Pfizer©).ResultsA total of 418 patients were enrolled. The mean age was 71.1 ± 12 years. Almost two thirds of the patients were prescribed active vitamin D analogs. The distribution of SARS‐CoV‐2 IgG before vaccination was 235 (93–454) AU/mL. After multiple regression analyses, active vitamin D analog use was found to be associated with higher SARS‐CoV‐2 IgG levels from prevaccination to 90 days postvaccination.ConclusionThis study demonstrated an association between higher SARS‐CoV‐2 IgG and active vitamin D analog use in hemodialysis patients.Clinical trial registration: The study information was registered in the UMIN‐CTR (UMIN 000046906).

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“…6 Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 infection, while others failed to document such a relation. 7 Other studies investigated the role of vitamin D supplementation on infection severity and outcome. 8,9 The present study aimed to evaluate the clinical and prognostic significance of baseline vitamin D levels in hospitalized Egyptian covid-19 patients.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 infection, while others failed to document such a relation. 7 Other studies investigated the role of vitamin D supplementation on infection severity and outcome. 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

Clinical and Prognostic Significance of Baseline Serum Vitamin D Levels in Hospitalized Egyptian Covid-19 Patients

Mostafa¹,

Mohammed²,

Elshennawy³

et al. 2022

IJGM

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Background andAim: Vitamin D is a hormone with essential roles in both cellular metabolism and immunity. It controls calcium homeostasis and modulates innate and adaptive immune system responses. Many studies suggested an association between vitamin D deficiency and clinical outcomes of covid-19 infection, while others failed to document such a relation. The present study aimed to evaluate the clinical and prognostic significance of baseline vitamin D levels in hospitalized Egyptian covid-19 patients. Patients and Methods: The present retrospective study included 300 hospitalized covid-19 patients. Patients were submitted to standard clinical, laboratory, and radiological assessment. According to vitamin D levels, patients were classified to have normal levels (≥30), insufficient levels (20-29) or deficient levels (<20). Results: According to their vitamin D levels, patients were classified into those with normal vitamin D (n=135), others with vitamin D insufficiency (n=114), and a third group with vitamin D deficiency (n=51). Patients with normal vitamin D levels and vitamin D insufficiency are significantly younger [median (IQR): 49.0 (39.0-57.0) versus 51.0 (40.0-61.0) and 55.0 (43.0-62.0) years, respectively, p=0.012] and had less frequency of severe disease (24.4% versus 40.4% and 51.0%, respectively) when compared with those with vitamin D deficiency. Moreover, they had significantly lower levels of D dimer [median (IQR): 1.

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Vitamin D for Recovery of COVID-19 in Patients With Chronic Kidney Disease

Cited by 5 publications

References 94 publications

Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches

Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches

Active vitamin D analog and SARS‐CoV‐2 IgG after BNT162b2 vaccination in patients with hemodialysis

Clinical and Prognostic Significance of Baseline Serum Vitamin D Levels in Hospitalized Egyptian Covid-19 Patients

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