Vitamin D for the treatment of chronic painful conditions in adults

Straube, Sebastian; Derry, Sheena; Moore, R Andrew; McQuay, Henry J

doi:10.1002/14651858.cd007771

Cited by 28 publications

(42 citation statements)

References 24 publications

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“…This may be because vitamin D has anti-inflammatory properties as well, and low 25(OH)D levels might enhance pain sensitization [42]. However, a previous literature review that sought high quality evidence from randomized controlled trials (RCT) on vitamin D to manage pain in chronic conditions found no consistent pattern that vitamin D treatment was better than placebo for any chronic painful condition [43].…”

Section: Discussionmentioning

confidence: 99%

Association of arthritis and vitamin D insufficiency with physical disability in Mexican older adults: findings from the Mexican Health and Aging Study

et al. 2016

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Objective Arthritis and vitamin D insufficiency are prevalent in older adults and are risk factors for disability. The objective of this study was to examine the effect of co-ocurring arthritis and vitamin D defficiency on upper-lower extremity functional limitations and disability in older adults. Methods We examined 1,533 participants aged ≥50 years from a subsample of the Mexican Health and Aging Study. Measures included sociodemographics, body mass index, comorbid conditions, falls, physical activity, physical function tests, functional limitations, activities of daily living (ADL), and vitamin D. Participants were categorized into four groups according to arthritis and vitamin D status: no vitamin D insufficiency and no arthritis (58.80%), vitamin D insufficiency only (27.49%), arthritis only (8.47%), and arthritis and vitamin D insufficiency (5.24%). Results Fourteen percent reported arthritis and 31.2% had vitamin D insufficiency. The arthritis and vitamin D insufficiency group was associated with upper-lower extremity functional limitations (odds ratio [OR] =1.82, 95% Confidence Interval[CI]=1.06-3.15, and OR=1.90, 95%CI=1.00-3.62, respectively) and ADL disability (OR=3.00, 95%CI=1.63-5.51) when compared with the no vitamin D insufficiency and no arthritis group (reference group). The arthritis only group was three times more likely to report upper-lower extremity functional limitations and ADL disability. The vitamin D insufficiency only group was not significantly associated with functional limitations nor ADL disability. Conclusion Arthritis and vitamin D insufficiency increased the risk of ADL disability in this population. However, the effect of arthritis and vitamin D insufficiency on upper- lower extremity functional limitations was not higher than the effect of arthritis only, but higher than the effect on vitamin D insufficiency alone.

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Section: Discussionmentioning

confidence: 99%

Association of arthritis and vitamin D insufficiency with physical disability in Mexican older adults: findings from the Mexican Health and Aging Study

et al. 2016

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“…Several case series, with one exception,6 suggest that vitamin D supplementation may have a beneficial effect 8 12–15. Supplementation (500 IU) reduced generalised pain after 3 months in patients with early rheumatoid arthritis,16 but not in two other small trials in participants with diffuse musculoskeletal pain,17 18 or a meta-analysis in patients with a wide variety of chronic painful conditions,19 using the available low-quality studies. To the best of our knowledge, there are no longitudinal cohort studies examining this topic.…”

Section: Introductionmentioning

confidence: 97%

Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study

et al. 2013

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“…Non-pharmacological treatments have been developed, investigated, and implemented, with Cochrane Reviews and protocols evaluating the available evidence for psychological, physical, and other non-medical interventions (e.g. cognitive behavioural and behavioural therapy, Eccleston 2014; Williams 2012; TENS, Nnoaham 2008; low-impact/intensity movement/exercise therapy, Wieland 2013; dietary, Straube 2015; and patient education, Engers 2008; Gross 2009). While evidence for the effectiveness of these interventions is of variable quantity and quality, the 2013 Scottish Intercollegiate Guideline Network (SIGN) guidelines on the management of chronic pain made strong recommendations on the use of exercise, based on evidence drawn from randomised controlled trials (RCTs), stating: "exercise and exercise therapies, regardless of their form, are recommended in the management of patients with chronic pain" (SIGN 2013).…”

Section: Introductionmentioning

confidence: 99%

Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews

Geneen

Moore²,

Clarke

et al. 2017

Cochrane Database of Systematic Reviews

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547

274

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BackgroundChronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning.Physical activity and exercise programmes are increasingly being promoted and offered in various healthcare systems, and for a variety of chronic pain conditions. It is therefore important at this stage to establish the efficacy and safety of these programmes, and furthermore to address the critical factors that determine their success or failure.ObjectivesTo provide an overview of Cochrane Reviews of adults with chronic pain to determine (1) the effectiveness of different physical activity and exercise interventions in reducing pain severity and its impact on function, quality of life, and healthcare use; and (2) the evidence for any adverse effects or harm associated with physical activity and exercise interventions.MethodsWe searched theCochrane Database of Systematic Reviews (CDSR) on the Cochrane Library (CDSR 2016, Issue 1) for systematic reviews of randomised controlled trials (RCTs), after which we tracked any included reviews for updates, and tracked protocols in case of full review publication until an arbitrary cut-off date of 21 March 2016 (CDSR 2016, Issue 3). We assessed the methodological quality of the reviews using the AMSTAR tool, and also planned to analyse data for each painful condition based on quality of the evidence.We extracted data for (1) self-reported pain severity, (2) physical function (objectively or subjectively measured), (3) psychological function, (4) quality of life, (5) adherence to the prescribed intervention, (6) healthcare use/attendance, (7) adverse events, and (8) death.Due to the limited data available, we were unable to directly compare and analyse interventions, and have instead reported the evidence qualitatively.Main resultsWe included 21 reviews with 381 included studies and 37,143 participants. Of these, 264 studies (19,642 participants) examined exercise versus no exercise/minimal intervention in adults with chronic pain and were used in the qualitative analysis.Pain conditions included rheumatoid arthritis, osteoarthritis, fibromyalgia, low back pain, intermittent claudication, dysmenorrhoea, mechanical neck disorder, spinal cord injury, postpolio syndrome, and patellofemoral pain. None of the reviews assessed 'chronic pain' or 'chronic widespread pain' as a general term or specific condition. Interventions included aerobic, strength, flexibility, range of motion, and core or balance training programmes, as well as yoga, Pilates, and tai chi.Reviews were well performed an...

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Vitamin D for the treatment of chronic painful conditions in adults

Cited by 28 publications

References 24 publications

Association of arthritis and vitamin D insufficiency with physical disability in Mexican older adults: findings from the Mexican Health and Aging Study

Association of arthritis and vitamin D insufficiency with physical disability in Mexican older adults: findings from the Mexican Health and Aging Study

Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study

Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews

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