Vitamin D hormone: A multitude of actions potentially influencing the physical function decline in older persons

Cesari, Matteo; Incalzi, Raffaele Antonelli; Zamboni, Valentina; Pahor, Marco

doi:10.1111/j.1447-0594.2010.00668.x

Cited by 78 publications

(46 citation statements)

References 116 publications

(204 reference statements)

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“…An extensive literature exists on the association between vitamin D deficiency and sarcopenia (reviewed by Cesari et al 2011), but proof of causality and pathogenetic mechanisms are still controversial (Stockton et al 2011). Nevertheless, a recent study reported that vitamin D supplementation to severely deficient persons produced marked improvements in fatigue that were accompanied, and perhaps mediated by augmented mitochondrial function, as measured in vivo by 31 P-NMR spectroscopy (Sinha et al 2013).…”

Section: Impact Of Age-related Conditions On Muscle Mitochondrial mentioning

confidence: 99%

Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

Marzetti

Calvani

Cesari

et al. 2013

The International Journal of Biochemistry & Cell Biology

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336

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Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on the pathophysiology of this syndrome. The pathogenesis of sarcopenia is multifaceted and encompasses lifestyle habits, systemic factors (e.g., chronic inflammation and hormonal alterations), local environment perturbations (e.g., vascular dysfunction), and intramuscular specific processes. In this scenario, derangements in skeletal myocyte mitochondrial function are recognized as major factors contributing to the age-dependent muscle degeneration. In this review, we summarize prominent findings and controversial issues on the contribution of specific mitochondrial processes – including oxidative stress, quality control mechanisms and apoptotic signaling – on the development of sarcopenia. Extramuscular alterations accompanying the aging process with a potential impact on myocyte mitochondrial function are also discussed. We conclude with presenting methodological and safety considerations for the design of clinical trials targeting mitochondrial dysfunction to treat sarcopenia. Special emphasis is placed on the importance of monitoring the effects of an intervention on muscle mitochondrial function and identifying the optimal target population for the trial.

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Section: Impact Of Age-related Conditions On Muscle Mitochondrial mentioning

confidence: 99%

Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

Marzetti

Calvani

Cesari

et al. 2013

The International Journal of Biochemistry & Cell Biology

Self Cite

484

336

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“…For example, selected nutrient deficits might underlie the relationship between kidney function and frailty. Indeed, vitamin D deficiency, which is highly prevalent among elders, may predispose to osteoporosis and related complications, such as vertebral fractures (Cesari et al 2011). Interestingly, it has been recently demonstrated that vitamin D supplementation improved muscle strength, functional ability, and balance in patients with reduced eGFR and vitamin D deficit undergoing conservative or peritoneal dialysis treatment (Taskapan et al 2011).…”

Section: Impact Of Egfr On Predictive Accuracy Of Frailtymentioning

confidence: 99%

Glomerular filtration rate in the elderly and in the oldest old: correlation with frailty and mortality

Montesanto

Rango

Berardelli

et al. 2014

AGE

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The equations for estimating kidney function have become very popular in the last decade. However, the clinical and prognostic meaning of these measures may be very different in older populations. Two cohorts of people aged 65-89 years (older sample) and 90 or more (oldest old sample) were used to investigate the prognostic significance of estimated glomerular filtration rate (eGFR). Additionally, we also investigated whether combining frailty and eGFR may improve the accuracy of frailty in predicting mortality. We found that lower eGFR values were significantly more frequent among frail subjects in both groups. eGFR < 30 was associated with increased risk for all-cause mortality either in subjects aged 65-89 years (HR = 3.71, 95% CI = 1.23-11.2) or in those aged 90 or more (HR = 1.53, 95% CI = 1.05-2.23). In the latter group, a not significant trend for increasing mortality was also observed among people with eGFR > 60 (HR = 1.28, 95% CI = 0.72-2.26). In addition, the oldest old subjects with eGFR > 60 and eGFR < 30 had the lowest hand-grip strength and ADL values. Combining eGFR and frailty status significantly improved the accuracy of frailty in predicting mortality only in the older sample. In conclusion, a U-shaped relationship exists between eGFR and mortality in the oldest old, but not in older individuals. Our findings suggest that eGFR needs to be adjusted for muscle mass/physical performance when estimating kidney function in people aged 90 or more. Nevertheless, in subjects aged 65-89 years, eGFR may improve the accuracy of frailty status in predicting prognosis, thus suggesting that eGFR may represent an additional dimension of frailty syndrome.

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“…Indeed, vitamin D deficiency, which is highly prevalent among elders, may predispose to osteoporosis and related complications, such as vertebral fractures 55 and, then, postural instability. Furthermore, vitamin D deficit preferentially weakens hip and thigh muscles, which are primarily involved in dynamic balance.…”

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confidence: 99%

Relationship Between Renal Function and Physical Performance in Elderly Hospitalized Patients

Lattanzio

Corsonello

Abbatecola

et al. 2012

Rejuvenation Research

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Chronic kidney disease (CKD) is increasingly recognized as a cause of worsening physical functioning in older patients. The Short Physical Performance Battery (SPPB) is highly reliable in older populations, but no data on older hospitalized patients with different degrees of kidney function are available. We aimed at testing the association between estimated glomerular filtration rate (eGFR) and SPPB, either global score (range 0-12) or its individual components (muscle strength, balance, and walking speed, each ranging from 0 to 4), in a sample of older hospitalized patients. Our series consisted of 486 patients aged 65 or more consecutively enrolled in 11 acute care medical wards participating to a multicenter observational study. eGFR was obtained by the Chronic Kidney Disease Epidemiological Collaboration (CKD-EPI) equation. Physical performance was objectively measured by the SPPB. The relationship between eGFR and SPPB was investigated by multiple linear regression analysis. Physically impaired patients (SPPB total score < 5) were older, had lower serum albumin and MiniMental State Examination (MMSE) scores as well as higher overall co-morbidity, prevalence of stroke, cancer, and anemia compared to those with intermediate (SPPB = 5-8) and good physical performance (SPPB = 9-12). Fully adjusted multivariate models showed that eGFR (modeled as 10 mL/min per 1.73 m 2 intervals) was independently associated with the SPPB total score (B = 0.49; 95% confidence interval [CI] = 0.18-0.66; p = 0.003), balance (B = 0.30; 95% CI = 0.10-0.49; p = 0.005), and muscle strength (B = 0.06; 95% CI = 0.01-0.10; p = 0.043), but not with walking speed (B = -0.04; 95% CI = -0.09-0.11; p = 0.107). In conclusion, reduced renal function is associated with poorer physical performance in older hospitalized patients. SPPB is worthy of testing to monitor changes in physical performance in elderly CKD patients.

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Vitamin D hormone: A multitude of actions potentially influencing the physical function decline in older persons

Cited by 78 publications

References 116 publications

Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

Glomerular filtration rate in the elderly and in the oldest old: correlation with frailty and mortality

Relationship Between Renal Function and Physical Performance in Elderly Hospitalized Patients

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