Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity

Galușca, Dorina; Popoviciu, Mihaela Simona; Babeş, Elena Emilia; Madalina, Vidican; Zaha, Andreea Atena; Babeș, Vlad Victor; Jurcă, Alexandru Daniel; Zaha, Dana Carmen; Bodog, Florian Dorel

doi:10.3390/medicina58020194

Cited by 16 publications

(13 citation statements)

References 70 publications

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“…The present study suggests an inverse relationship between vitamin D levels and TSH in children with non-autoimmune hypothyroidism. This aligns with evidence demonstrating vitamin D supplementation's impact on TSH in autoimmune thyroid disease (18,19). Galusca et al's meta-analysis exempli es this, decreased TSH and thyroid antibodies upon supplementation (19).…”

Section: Discussionsupporting

confidence: 77%

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Vitamin D deficiency and TSH level, a relationship in nonautoimmune hypothyroidism pediatrics

MohammadTaheri,

Kazemi,

Ahmadi

et al. 2024

Preprint

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Background and purpose: Vitamin D has a crucial role in the organs' function and is essential for specific populations like pediatrics. Indeed, the thyroid function correlates with the Vitamin D level in the body, so the consequences of this depletion are very important. In non-autoimmune hypothyroidism, the Vitamin D level influences the thyroid function which could be tracked with thyroid stimulating hormone. Design and methods: In this cross-sectional study, among 2,503 children aged three to 18 who were referred to the pediatrics endocrinology and metabolic clinic in Zanjan city in 2022-2023, 102 children with non-autoimmune hypothyroidism who did not have a history of other diseases or the use of drugs affecting thyroid function in last three months were selected and entered this study. Data were analyzed by IBM SPSS 24 using binary logistic regression. Results: The mean (standard deviation) vitamin D level in the study population was 27.66 (13.17) ng/ml, with a deficiency prevalence of 63.7%. The odds of vitamin D deficiency significantly increased 70 percent with one unit (mIU)/liter (L) increasing in TSH (OR=1.70, CI 95%:1.19-2.43, P= 0.003. However, weight, height, sex, age, body mass index, and season had no statistically significant relationship. Conclusions: The level of vitamin D and TSH level have a positive correlation in non-autoimmune hypothyroidism pediatric patients. Indeed, the correcting vitamin D deficiently reduces the TSH level. So, we can use vitamin D supplements along with other treatments in treating hypothyroidism.

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Section: Discussionsupporting

confidence: 77%

“…This aligns with evidence demonstrating vitamin D supplementation's impact on TSH in autoimmune thyroid disease (18,19). Galusca et al's meta-analysis exempli es this, decreased TSH and thyroid antibodies upon supplementation (19). Similarly, Metwalley et al's study in children with autoimmune hypothyroidism yielded comparable results (18).…”

Section: Discussionsupporting

confidence: 72%

Vitamin D deficiency and TSH level, a relationship in nonautoimmune hypothyroidism pediatrics

MohammadTaheri,

Kazemi,

Ahmadi

et al. 2024

Preprint

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“…On the other hand, Vitamin D is connected to numerous CVDs, including infectious myocarditis, which is caused by aberrant immunological reactions as a result of vitamin D receptor inadequacy. 38,39 In the current study, we found that people with prediabetes have greater CVR scores than normal participants regardless of their (25(OH)D) levels, we also did not identify a significant link between HbA1c and (25(OH)D) levels in prediabetics or healthy participants.…”

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confidence: 72%

Cardiovascular Risk Among Saudi Adults with Prediabetes: A Sub-Cohort Analysis from the Heart Health Promotion (HHP) Study

Fayed¹,

Alzeidan²,

Esmaeil³

et al. 2022

IJGM

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Background: This study aimed to estimate the prevalence of prediabetes among Saudi adults and to evaluate their risk of developing cardiovascular diseases. Methods: This is a cohort of 2470 Saudi adults attending employee clinics in the university hospital. WHO-STEPs approach was used to collect sociodemographic (age, gender, and education), clinical (body mass index and blood pressure) and laboratory data (HbA1c, lipid profile and vitamin D concentration). Prediabetes was defined according to HbA1c level of 5.7-6.4%. Cardiovascular risk (CVR) scores were evaluated using the Framingham Risk Score. SPSS was used for data analysis to investigate the relation between different CVR and prediabetes. Results: Prediabetes affected 25.1% of the study population. Males had higher rates of prediabetes than females (27.5% versus 23.5%). The prevalence of prediabetes increased from 11.6% among young individuals (18-29 years) to 56.0% among participants 60 years and older. Prediabetes patients exhibited considerably higher levels of all cardiovascular risk factors and nearly half of them (49.3%) had at least two risk factors. The prevalence of intermediate CVR among prediabetics was 13.2% compared to just 2.9% among the normal group, and high CVR was defined in 3.7% among prediabetics compared to only 1.7% in the normal group. Having prediabetes increased the odds to develop higher CVR of 2.64 times compared to those without prediabetes (OR = 2.64, 95% CI = 1.51-4.64) and the level of vitamin D did not affect the odds of CVR. Conclusion: Prediabetes is quite prevalent among Saudi adults, and they are at a higher risk of cardiovascular diseases. Patients with prediabetes have higher cardiac risk scores when compared to normal participants across the whole spectrum of (25(OH)D) concentrations. Additionally, no significant correlation was observed between HbA1c and (25(OH)D) levels in prediabetics or normoglycemic subjects.

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“…The serum concentration of vitamin D showed a significantly lower value in Graves’ disease patients who were not in remission compared to those who were. Moreover, in a randomized prospective study, the thyroid volume and the degree of exophthalmos revealed a statistically significant correlation with vitamin D levels [ 105 , 106 ].…”

Section: Vitamin D Deficiency and Epigenetic Dysregulations In Autoim...mentioning

confidence: 99%

Vitamin D as a Nutri-Epigenetic Factor in Autoimmunity—A Review of Current Research and Reports on Vitamin D Deficiency in Autoimmune Diseases

2022

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Epigenetics is a series of alterations regulating gene expression without disrupting the DNA sequence of bases. These regulatory mechanisms can result in embryogenesis, cellular differentiation, X-chromosome inactivation, and DNA-protein interactions. The main epigenetic mechanisms considered to play a major role in both health and disease are DNA methylation, histone modifications, and profiling of non-coding RNA. When the fragile balance between these simultaneously occurring phenomena is disrupted, the risk of pathology increases. Thus, the factors that determine proper epigenetic modeling are defined and those with disruptive influence are sought. Several such factors with proven negative effects have already been described. Diet and nutritional substances have recently been one of the most interesting targets of exploration for epigenetic modeling in disease states, including autoimmunity. The preventive role of proper nutrition and maintaining sufficient vitamin D concentration in maternal blood during pregnancy, as well as in the early years of life, is emphasized. Opportunities are also being investigated for affecting the course of the disease by exploring nutriepigenetics. The authors aim to review the literature presenting vitamin D as one of the important nutrients potentially modeling the course of disease in selected autoimmune disorders.

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Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity

Cited by 16 publications

References 70 publications

Vitamin D deficiency and TSH level, a relationship in nonautoimmune hypothyroidism pediatrics

Vitamin D deficiency and TSH level, a relationship in nonautoimmune hypothyroidism pediatrics

Cardiovascular Risk Among Saudi Adults with Prediabetes: A Sub-Cohort Analysis from the Heart Health Promotion (HHP) Study

Vitamin D as a Nutri-Epigenetic Factor in Autoimmunity—A Review of Current Research and Reports on Vitamin D Deficiency in Autoimmune Diseases

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