2020
DOI: 10.18388/abp.2020_2905
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Vitamin D in autoimmune bullous disease

Abstract: Numerous epidemiological studies have suggested a link between vitamin D deficiency and the development of various autoimmune diseases, including diabetes mellitus type 1, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis or systemic lupus erythematosus. More recently, such a link has been also proposed for autoimmune bullous diseases (AIBD). This is a relatively rare and potentially life-threatening, organ-specific group of inflammatory skin diseases characterized by the presence of tissue-… Show more

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Cited by 5 publications
(4 citation statements)
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“…The hormonally active, UVB-induced vitamin D metabolite, 1,25-dihydroxyvitamin D 3 (calcitriol), participates in regulation of immune responses through binding to the vitamin D receptor expressed in multiple cells of the immune system [ 8 ]. There are several lines of evidence indicating vitamin D involvement in AIBD.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The hormonally active, UVB-induced vitamin D metabolite, 1,25-dihydroxyvitamin D 3 (calcitriol), participates in regulation of immune responses through binding to the vitamin D receptor expressed in multiple cells of the immune system [ 8 ]. There are several lines of evidence indicating vitamin D involvement in AIBD.…”
Section: Discussionmentioning
confidence: 99%
“…Similar to what has been previously described in ANA-positive healthy individuals [ 6 , 7 ], we hypothesized that an abnormal status of immunomodulatory vitamin D could play a role in anti-BP180-NC16A reactivity in healthy people. In fact, hypovitaminosis D has been reported to be more common in AIBD patients than in the general population [ 8 , 9 ], but nothing is known about vitamin D and BP autoantibodies in healthy populations. In addition, we aimed to evaluate the cytokine profile of anti-BP180-NC16A IgG-reactive versus anti-BP180-NC16A IgG-negative healthy blood donors, considering that an altered cytokine expression is found in BP patients [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, there is strong evidence indicating an elevated prevalence of VDD among older age subjects [ 27 , 28 ], persons with darker skin pigmentation [ 44 ], obesity, and metabolic syndrome [ 27 , 45 ]. High VDD was demonstrated in patients with metabolic bone disorders [ 46 ], autoimmune diseases [ 47 , 48 , 49 ], including rheumatic disorders [ 50 , 51 , 52 , 53 ], inflammatory bowel diseases [ 54 , 55 ], infectious diseases [ 56 , 57 ], endocrine system disorders (type I diabetes mellitus, thyroid diseases, etc.) [ 58 , 59 , 60 ], cardiovascular [ 61 , 62 , 63 ], nervous system disorders [ 64 , 65 , 66 ], kidney diseases [ 67 ], chronic obstructive pulmonary disease [ 68 ], and tumors [ 69 ].…”
Section: Consensus Recommendationsmentioning
confidence: 99%
“…Проте накопичено достатньо даних щодо збільшення частки ДВД в осіб старших вікових груп [1,32,35], осіб з надмірною масою тіла та метаболічним синдромом [1,32,58], темною пігментацією шкіри [59]. Крім того, продемонстровано збільшення ДВД у хворих з метаболічними захворюваннями кісткової тканини [60], осіб з інфекційною [61,62] та автоімунною патологією [63,64,65], зокрема запальними захворюваннями кишечника [66,67], ревматичною патологією [68][69][70][71] тощо, захворюваннями ендокринної системи, зокрема цукровим діабетом [72,73], гіпогонадизмом [74], патологією щитоподібної залози [75,76] тощо, захворюваннями серцево-судинної [77][78][79][80], нервової системи [81][82][83], нирок [84], онкологічними захворюваннями [85], тривалим прийомом лікарських засобів з негативним впливом на метаболізм вітаміну D [86,87], а також зв'язок зі збільшеним рівнем смертності з різних причин [88][89][90][91]. Тому визначення сироваткового рівня 25(OH)D у цієї категорії осіб може бути корисним для ефективної профілактики й лікування ДВД [15,22,…”
Section: скринінг дефіциту вітаміну D у дорослихunclassified