Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk

Somoza-Moncada, María Montserrat; Turrubiates-Hernández, Francisco Javier; Muñoz‐Valle, José Francisco; Gutiérrez-Brito, Jesús Alberto; Díaz-Pérez, Saúl Alberto; Aguayo-Arelis, Adriana; Hernández‐Bello, Jorge

doi:10.3390/nu15071765

Cited by 12 publications

(5 citation statements)

References 128 publications

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“…The association between depression and vitamin D deficiency has long been an attractive topic for researchers worldwide. Clinical studies have shown that these two widespread pathological conditions go hand in hand [23], yet little is known about their common molecular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency

Sala-Cirtog,

Sirbu

2024

IJMS

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Depression and vitamin D deficiency are often co-occurring pathologies, the common pathogenetic ground of which includes an augmented inflammatory response. However, the molecular details of this relationship remain unclear. Here, we used a bioinformatic approach to analyze GEO transcriptome datasets of major depressive disorder (MDD) and vitamin D deficiency (VDD) to identify the hub genes within the regulatory networks of commonly differentially expressed genes (DEGs). The MDD-VDD shared regulatory network contains 100 DEGs (71 upregulated and 29 downregulated), with six hub genes (PECAM1, TLR2, PTGS2, LRRK2, HCK, and IL18) all significantly upregulated, of which PTGS2 (also known as COX2) shows the highest inference score and reference count. The subsequent analysis of the miRNA-transcription factors network identified COX2, miR-146a-5p, and miR-181c-5p as key co-regulatory actors in the MDD-VDD shared molecular pathogenic mechanisms. Subsequent analysis of published MDD and VDD transcriptome data confirmed the importance of the identified hub genes, further validating our bioinformatic analytical pipeline. Our study demonstrated that PTGS2 was highly upregulated in both depressive patients and patients with low vitamin D plasma levels. Therefore, regulators targeting PTGS2, like miR-146a-5p and miR181c-5p, may have great potential in controlling both diseases simultaneously, accentuating their role in future research.

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Section: Discussionmentioning

confidence: 99%

“…An indoor lifestyle has raised vitamin D deficiency (VDD) to a global public health status, impacting a billion people worldwide [23]. Mostly known for its role in bone health, the fat-soluble "sunshine" vitamin [24] can also act as a neuroactive steroid with anti-inflammatory and antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency

Sala-Cirtog,

Sirbu

2024

IJMS

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“…A meta-analysis showed that vitamin D level determination and vitamin D supplementation are affordable and safe. Thus, both actions could be good routine clinical practices in patients with mental illnesses such as depression, suicidal thoughts, and anxiety, as vitamin D enhances serotonin synthesis [ 25 ]. A cost-effective analysis of the national program of vitamin D supplementation among Iranian adolescents aged 11–18 years showed that vitamin D supplementation was effective in reducing adolescent depressive symptoms, as determined through cost savings and increases in QALYs compared to those who received no intervention, strongly suggesting that vitamin D supplementation may be a cost-effective strategy for decreasing depression symptoms in adolescents with a 100% probability [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Does Vitamin D3 Supplementation Improve Depression Scores among Rural Adolescents? A Randomized Controlled Trial

Satyanarayana,

Suryanarayana,

Yesupatham

et al. 2024

Nutrients

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Background: Contemporary evidence has been established demonstrating that stunted vitamin D levels are associated with depression, poor mood, and other mental disorders. Individuals with normal vitamin D levels have a much lower probability of developing depression. Improving vitamin D levels by supplementation has shown betterment in depressive patients among different age groups. The objective of this study was to assess the effect of vitamin D supplementation on depression scores among rural adolescents. Material and methods: This study was a cluster randomized controlled trial carried out for a period of 3 years among adolescents from rural Kolar. The sample size was calculated based on previous research and was determined to be 150 for each group. The intervention arm received 2250 IU of vitamin D, and the control arm received a lower dose of 250 IU of vitamin D for 9 weeks. To assess sociodemographic status, a pretested, semi-structured questionnaire was used, and, to assess depression, the Beck Depression Inventory (BDI-II) was used. A baseline assessment was carried out for vitamin D status and depression status, followed by a post-intervention assessment. From the start of the trial, the participants were contacted every week by the pediatric team to investigate any side effects. Results: Out of 235 school students in the vitamin D supplementation arm, 129 (54.9%) belonged to the 15 years age group, 124 (52.8%) were boys, and 187 (79.6%) belonged to a nuclear family. Out of 216 school students in the calcium supplementation arm, 143 (66.2%) belonged to the 15 years age group, 116 (53.7%) were girls, and 136 (63%) belonged to a nuclear family. By comparing Beck depression scores before and after the intervention, it was found that the vitamin D intervention arm showed a statistically significant reduction in Beck depression scores. Conclusions: The present study showed that vitamin D supplementation reduced depression scores, showing some evidence that nutritional interventions for mental health issues such as depression are an excellent option. Vitamin D supplementation in schools can have numerous beneficiary effects on health while mutually benefiting mental health.

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“…Omega-3 fatty acids, DHA, and EPA, with antioxidant and anti-inflammatory properties, have shown benefits in depression management [ 89 ]. Vitamin D modulates proinflammatory cytokines, such as IL-6 and TNF-α, linked with systemic inflammation in depression and suicidal tendencies [ 90 ]. Given the emerging role of inflammation in depression [ 91 ], several inflammatory biomarkers have the ability to diagnose elevated suicidal risk in MDD, and specific anti-inflammatory agents exhibit the potential to mitigate suicidal behaviors and reduce suicidal ideation.…”

Section: Discussionmentioning

confidence: 99%

Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review

Kim,

Shin,

Chang

2023

IJMS

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Major depressive disorder (MDD) is a highly prevalent psychiatric condition affecting an estimated 280 million individuals globally. Despite the occurrence of suicidal behaviors across various psychiatric conditions, MDD is distinctly associated with the highest risk of suicide attempts and death within this population. In this study, we focused on MDD to identify potential inflammatory biomarkers associated with suicidal risk, given the relationship between depressive states and suicidal ideation. Articles published before June 2023 were searched in PubMed, Embase, Web of Science, and the Cochrane Library to identify all relevant studies reporting blood inflammatory biomarkers in patients with MDD with suicide-related behaviors. Of 571 articles, 24 were included in this study. Overall, 43 significant biomarkers associated with MDD and suicide-related behaviors were identified. Our study provided compelling evidence of significant alterations in peripheral inflammatory factors in MDD patients with suicide-related behaviors, demonstrating the potential roles of interleukin (IL)-1β, IL-6, C-reactive protein, C-C motif chemokine ligand 2, and tumor necrosis factor-α as biomarkers. These findings underscore the intricate relationship between the inflammatory processes of these biomarkers and their interactions in MDD with suicidal risk.

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Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk

Cited by 12 publications

References 128 publications

Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency

Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency

Does Vitamin D3 Supplementation Improve Depression Scores among Rural Adolescents? A Randomized Controlled Trial

Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review

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