Vitamin D in health and disease: Current perspectives

Zhang, Ran; Naughton, Declan P.

doi:10.1186/1475-2891-9-65

Cited by 296 publications

(256 citation statements)

References 154 publications

(134 reference statements)

Supporting

Mentioning

226

Contrasting

Unclassified

Order By: Relevance

“…Low level of vitamin D3 is associated with osteoporosis, rickets, cardiovascular disorder, some autoimmune disease, multiple sclerosis, diabetes mellitus and some cancers (9). It has been suggested that low level of vitamin D decreases the survival of general population and CKD and HD patients (10,11).…”

Section: Discussionmentioning

confidence: 99%

Relationship of circulating levels of 25(OH)D with parathyroid hormone in various stages of chronic kidney disease

Jalalzadeh¹,

Mousavinasab²,

Rostami³

2017

J Renal Inj Prev

View full text Add to dashboard Cite

In a study on 115 patients with stages 2 to 5 CKD and the age of more than 14 years old, we found vitamin D deficiency as the serum level of 25 (OH)D3 <30 ng/mL, is common in CKD patients. There was a positive correlation between the serum levels of 25(OH)D3 and levels of PTH. The findings indicated that administration of vitamin D3 in all CKD patients with vitamin D deficiency was effective in reducing the serum levels of PTH. Please cite this paper as: Introduction:Vitamin D deficiency is common in both general population and chronic kidney disease (CKD) patients. Objectives: The aim of this study was to compare 25(OH)D3 levels in stages 2 to 5 of CKD patients and to evaluate whether inactive vitamin D supplement could prevent increasing of serum PTH levels. Patients and Methods: A total of 58 stages 2-4 CKD and 57 stage 5 CKD hemodialysis (HD) patients who had 25(OH)D3 <30 ng/mL were considered. All cases were under appropriate treatment for preventing secondary hyperparathyroidism. At the beginning, serum levels of vitamin D3, intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), alkaline phosphate (ALP) and albumin were measured. Patients received 300 000 IU/IM vitamin D3 and after 2 months this dosage was repeated, if it was necessary. All biochemical markers were checked and the effect of vitamin D3 was evaluated. Results: At base line, serum levels of 25(OH)D3 and PTH in patients with stages 2 to 5 of CKD were; 14.85±7.8 ng/mL (stage 2), 70.8 ± 16.8 pg/mL (stage 2); 16.48 ± 7.8 ng/mL (stage 3), 69.6 ± 39.2 pg/mL (stage 3); 16.33 ± 8.1 ng/mL (stage 4), 123.74 ± 92.5 pg/mL (stage 4); and 13.86 ± 6.5 ng/mL (stage 5) and 567.23 ± 276.7 pg/mL (stage 5), respectively. Two months after injections, 25(OH)D3 and PTH were changed as follow; 28.62 ng/mL (P = 0.001) (stage 2), 59.38 pg/mL (P = 0.34) (stage 2); 37.79 ng/mL (P < 0.001) (stage 3), 62.41 pg/ml (P = 0.18) (stage 3); 31.14 ng/mL (P = 0.001) (stage 4), 91.02 ± 69.4 pg/mL (P = 0.003) (stage 4) and 48.48 ng/mL (P < 0.001) (stage 5) and also 282.77 pg/mL (P < 0.001) (stage 5), respectively. Conclusion: The result of this study showed the vitamin D3 levels increased in all stages after 2 months. Also, the findings indicated that administration of vitamin D3 in all patients of the study groups reduced serum PTH levels. However, the rate of reduction was higher in stages 4 and 5 of CKD as compared to stages 2 and 3 of CKD (P < 0.001).This result encourages us to prescribe supplement vitamin D3 if the level is less than 30 ng/mL.

show abstract

Section: Discussionmentioning

confidence: 99%

Relationship of circulating levels of 25(OH)D with parathyroid hormone in various stages of chronic kidney disease

Jalalzadeh¹,

Mousavinasab²,

Rostami³

2017

J Renal Inj Prev

View full text Add to dashboard Cite

show abstract

“…Others have demonstrated that diet has an important effect on vitamin D levels and this should not be overlooked. 8 However, since so many children do not have adequate vitamin D in their diets it should not be surprising that the prevalence of vitamin D insufficiency is high. 9,10 This finding, in combination with the recent increase in the recommended daily vitamin D intake for children suggests that far more of our patients than previously recognized require vitamin D supplementation.…”

Section: Discussionmentioning

confidence: 99%

A study of vitamin - D status in epileptic children in age group of 2-15 years

2016

View full text Add to dashboard Cite

“…The precursors of vitamin D are vitamins D 3 (cholecalciferol) and D 2 (ergocalciferol) [6]. Vitamin D 3 is formed by exposure to solar ultraviolet B (UVB) rays from its precursor, 7-dehydrocholesterol, present in the skin.…”

Section: Source and Homeostasismentioning

confidence: 99%

“…The 25(OH) D released by the liver is not the biologically active form of vitamin D, as that still needs a kidney hydroxylation to become an active compound. Action by the kidney turns 25(OH) D to 1,25 dihydroxyvitamin D (1,25(OH) 2 D) or calcitriol, the active form of vitamin D [6].…”

Section: Source and Homeostasismentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and respiratory infections

Fiol

Barberato‐Filho

Lopes

et al. 2015

J Infect Dev Ctries

View full text Add to dashboard Cite

Vitamin D or 1,25-hydroxyvitamin D (1,25(OH) 2 D) has a well-established role in calcium homeostasis. In recent years, the discovery of vitamin D-metabolizing enzymes and vitamin D receptor (VDR) in the lungs and various cells of the immune system has led to numerous studies conducted to evaluate its role in respiratory functions and, in particular, upper respiratory tract infections (URTIs). A PubMed literature search was done using vitamin D and respiratory infections as key words. Only clinical studies were considered. This study aimed to review recent clinical and epidemiological studies conducted in adults and children, and to evaluate the functional role of vitamin D in respiratory infections. The evaluated studies show an important immunomodulatory role of vitamin D, which reduces the incidence and risk of URTIs, both in children and in adults. Combating URTIs can be done prophylactically, associating the use of vaccines against Streptococcus pneumoniae with strengthening the immune system through supplementation with vitamin D. These actions can significantly contribute to reducing the number of URTIs, the use of antibiotics, and consequently, the rates of antimicrobial resistance.

show abstract

Vitamin D in health and disease: Current perspectives

Cited by 296 publications

References 154 publications

Relationship of circulating levels of 25(OH)D with parathyroid hormone in various stages of chronic kidney disease

Relationship of circulating levels of 25(OH)D with parathyroid hormone in various stages of chronic kidney disease

A study of vitamin - D status in epileptic children in age group of 2-15 years

Vitamin D and respiratory infections

Contact Info

Product

Resources

About