Vitamin D in health and disease: the global threat of vitamin D deficient rickets

Kieß, Wieland; Bae, Yoon Ju; Penke, Melanie; Geserick, Mandy; Kratzsch, Jürgen

doi:10.1515/jpem-2016-0054

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…1 In children, vitamin D is essential for skeletal health. 12 Deficiency in children has also been linked to increased risk of allergies and asthma, 13 and cardiovascular risk markers. 14 In obese children, low levels of vitamin D may play a role in the pathophysiology of impaired glucose tolerance.…”

Section: Introductionmentioning

confidence: 99%

Body Mass Index is a Strong Predictor of Vitamin D Deficiency in Multiethnic Obese Children

Kannan¹,

Visintainer²,

Ganguri³

et al. 2017

Obes Res Open J

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CitationKannan S, Visintainer P, Ganguri HB, Conroy R, Gudala M, Wittcopp C. The main objective of this study is to determine predictors of vitamin D deficiency in obese children. Methods: Children aged 5-14 years with body mass index z-score (BMIZ)>95% were enrolled. Data included height, weight, ethnicity, season, dietary intake, serum 25-hydroxy vitamin D test: (25(OH)D), parathyroid hormone, calcium, insulin, glucose, high sensitivity C-reactive protein (CRP), lipids, aspartate aminotransferase (AST), alanine transaminase (ALT) and waist circumference. BMIZ calculation in children was categorized into ≥2.5 (high) and <2.5 (low). Serum 25(OH)D levels were dichotomized as <20 ng/mL (deficient) or ≥20 ng/mL (sufficient). Results: Ninety-one children completed the study. Mean BMIZ was 31.3±6.3 kg/m 2 . Mean 25(OH)D level was 21.2±7.6 ng/mL. A base logistic regression model showed odds of a deficient 25(OH)D was more than 3-times higher in children with a high BMIZ (OR: 3.35, 95% CI: 1.07-10.43). African-American children were more likely than Caucasian children to have low 25(OH)D (OR: 6.68, 95% CI: 1.31-36.13). Children enrolled in seasons other than winter were less likely to have a low 25(OH)D. Adjustment for nutrients and serum cardiovascular disease risk markers did not significantly alter the relationship between low 25(OH)D and BMIZ. Conclusions: The risk for vitamin D deficiency increases in children with severe obesity (BMIZ≥2.5 SD) and does not significantly change by season, ethnicity, nutrient intake, or cardiovascular disease risk parameters.

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Section: Introductionmentioning

confidence: 99%

Body Mass Index is a Strong Predictor of Vitamin D Deficiency in Multiethnic Obese Children

Kannan¹,

Visintainer²,

Ganguri³

et al. 2017

Obes Res Open J

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Sustenance and Its Consequences

Palkovich

2024

Bioarchaeology and Social Theory

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Vitamin D deficiency in childhood: old lessons and current challenges

Antonucci

Locci

Clemente

et al. 2018

Journal of Pediatric Endocrinology and Metabolism

169

120

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Hypovitaminosis D in childhood is a re-emerging public health problem in developed countries. New life style habits, current "epidemics" of obesity in children and adolescents worldwide, and other preventable risk factors may play a role in favoring the occurrence of vitamin D deficiency. In addition to skeletal consequences, hypovitaminosis D has been found to be involved in the development of serious health extra-skeletal problems in childhood, including atopy and autoimmunity. The increasing concerns about the global health impact of vitamin D deficiency make further research necessary to fill the gaps of knowledge in this field, and particularly to establish universally accepted "normal" serum 25(OH)D levels in the pediatric population, and to improve strategies for the screening, prevention and treatment of hypovitaminosis D. This review discusses the key points of hypovitaminosis D in childhood in the light of new knowledge, and highlights the limitations of current strategies to control this condition.

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Vitamin D in health and disease: the global threat of vitamin D deficient rickets

Cited by 4 publications

References 14 publications

Body Mass Index is a Strong Predictor of Vitamin D Deficiency in Multiethnic Obese Children

Body Mass Index is a Strong Predictor of Vitamin D Deficiency in Multiethnic Obese Children

Sustenance and Its Consequences

Vitamin D deficiency in childhood: old lessons and current challenges

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