Vitamin D in liver cancer: novel insights and future perspectives

Markotić, Antonio; Kelava, Tomislav; Markotić, Helena; Silovski, Hrvoje; Mrzljak, Anna

doi:10.3325/cmj.2022.63.187

Cited by 3 publications

(4 citation statements)

References 67 publications

(76 reference statements)

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“…This might be related to vitamin D properties, including anti-proliferative, anti-angiogenic, proapoptotic, and prodifferentiative effects [ 30 ]. However, the main impact of vitamin D in hepatocellular carcinoma seems to be the inhibition of cell proliferation [ 31 ]. In a German prospective cohort study, a severe vitamin D deficiency was associated with advanced stages of hepatocellular carcinoma and a higher mortality risk.…”

Section: Discussionmentioning

confidence: 99%

“…This association was independent of the MELD score and alpha-fetoprotein levels [ 20 ]. Although the results of observational studies regarding the association between vitamin D status and liver cancer development are promising, they are still inadequate [ 31 ]. In a retrospective study of cholangiocarcinoma patients, vitamin D intake was associated with shorter disease-free survival in patients who underwent surgery [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…In patients with Crohn’s disease, the frequency of vitamin D deficiency was estimated to be as high as 70% [ 30 ]. PSC occurrence was an independent predictor of vitamin D deficiency (≤50 nmol/L) in patients with Crohn’s disease and ileal pouch–anal anastomosis (odds ratio: 7.56; 95% CI: 2.39–24.08; p = 0.001) [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis

et al. 2023

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Vitamin D deficiency has been linked with adverse events in various liver diseases. The present study aimed to recognize the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary sclerosing cholangitis (PSC). Patients with a diagnosis of PSC (n = 354), followed by the autoimmune liver disease clinic at the University of Alberta, were included. Patients with vitamin D levels < 25 nmol/L were defined as severely deficient. Univariate and multivariate analyses were conducted using the Cox proportional hazards regression models. The mean vitamin D level was 59 ± 2 nmol/L, and 63 patients (18%) had a severe vitamin D deficiency. Patients with a severe vitamin D deficiency were 2.5 times more likely to experience hepatobiliary malignancies (HR 2.55, 95% CI, 1.02–6.40, p = 0.046). A severe vitamin D deficiency at diagnosis (HR 1.82, 95% CI, 1.05–3.15, p = 0.03) and persistent deficiencies over time (HR 2.26, 95% CI, 1.17–4.37, p = 0.02) were independently associated with a higher risk of poor clinical liver outcomes. A severe vitamin D deficiency at diagnosis and persistent deficiency at longitudinal assessments were associated with liver-related mortality or the need for liver transplantation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis

et al. 2023

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“…The association between the serum level of vitamin D and the risk of various cancers has been investigated several times in the past. Colorectal cancer (176), breast cancer (177), skin cancer (178), prostate cancer (179), liver cancer (180), and head and neck cancers (181) are some of the examples. According to Ma et al's study, high blood levels of vitamin D was correlated with a 33% reduction in the risk of colorectal cancer (182).…”

Section: Cancermentioning

confidence: 99%

Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review

Ghaseminejad-Raeini,

Ghaderi,

Sharafi

et al. 2023

Front. Immunol.

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For many years, vitamin D has been acknowledged for its role in maintaining calcium and phosphate balance. However, in recent years, research has assessed its immunomodulatory role and come up with conflicting conclusions. Because the vitamin D receptor is expressed in a variety of immune cell types, study into the precise role of this molecule in diseases, notably autoimmune disorders, has been made possible. The physiologically activated version of vitamin D also promotes a tolerogenic immunological condition in addition to modulating innate and acquired immune cell responses. According to a number of recent studies, this important micronutrient plays a complex role in numerous biochemical pathways in the immune system and disorders that are associated with them. Research in this field is still relatively new, and some studies claim that patients with severe autoimmune illnesses frequently have vitamin D deficiencies or insufficiencies. This review seeks to clarify the most recent research on vitamin D’s immune system-related roles, including the pathophysiology of major disorders.

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Vitamin D receptor gene polymorphisms, bioavailable 25-hydroxyvitamin D, and hepatocellular carcinoma survival

Shu,

Zhang,

Dong

et al. 2024

JNCI: Journal of the National Cancer Institute

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Background Little is known about the role of vitamin D receptor polymorphisms and their interaction with vitamin D status in hepatocellular carcinoma (HCC) prognosis. Methods We evaluated the association of TaqI, BsmI, Cdx-2, and ApaI polymorphisms, individually and in combination, with liver cancer-specific (LCSS) and overall survival (OS) among 967 patients with newly diagnosed HCC. Subsequently, we examined whether these polymorphisms modified the association between serum bioavailable 25-hydroxyvitamin D (25OHD) concentrations and survival. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results During a median follow-up of 1017 days, 393 deaths occurred, with 360 attributed to HCC. Having TaqI G allele (HRper allele = 1.30, 95% CI = 1.08 to 1.57) or BsmI T allele (HRper allele = 1.41, 95% CI = 1.01 to 1.99) was associated with worse LCSS. Carrying increasing numbers of protective alleles was associated with superior LCSS (HR6-8 vs 0-3 = 0.52, 95% CI = 0.34 to 0.80). The inverse association of bioavailable 25OHD with LCSS was only significant in patients with TaqI AA (HRQuartile 4 vs Quartile 1 = 0.63, 95% CI = 0.44 to 0.92), BsmI CC (HRQuartile 4 vs Quartile 1 = 0.62, 95% CI = 0.44 to 0.88), and 6 to 8 protective alleles (HRQuartile 4 vs Quartile 1 = 0.45, 95% CI = 0.23 to 0.87). Similar associations were observed for OS. Conclusions Patients carrying wild-type TaqI, BsmI, or more protective alleles had improved survival and might benefit from optimizing bioavailable 25OHD status.

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Vitamin D in liver cancer: novel insights and future perspectives

Cited by 3 publications

References 67 publications

Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis

Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis

Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review

Vitamin D receptor gene polymorphisms, bioavailable 25-hydroxyvitamin D, and hepatocellular carcinoma survival

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