Vitamin D in prostate cancer

Trump, Donald L.; Aragon‐Ching, Jeanny B.

doi:10.4103/aja.aja_14_18

Cited by 76 publications

(56 citation statements)

References 116 publications

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“…Although some consider the vitamin as an antioxidant, high-quality evidence from human studies raised controversy concerning its ability to ameliorate oxidative stress in vivo [ 139 ]. Nevertheless, the role of vitamin D compounds in the treatment and causation of cancer has been examined and postulated since the 1970s [ 140 ]. The anti-tumor effect of the vitamin involves cell cycle arrest, inhibition of tumor cell proliferation, growth and invasiveness, and inflammatory signaling [ 141 ].…”

Section: Antioxidants and Psa Kineticsmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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The quest for dietary patterns and supplements efficient in down-regulating prostate-specific antigen (PSA) concentrations among men with prostate cancer (PCa) or increased PCa risk has been long. Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea catechins, cernitin, vitamins (C, E, D) and multivitamins, medicinal mushrooms (Ganoderma lucidum), fruit extracts (saw palmetto, cranberries, pomegranate), walnuts and fatty acids, as well as combined supplementations of all, have been examined in randomized controlled trials (RCTs) in humans, on the primary, secondary, and tertiary PCa prevention level. Despite the plethora of trials and the variety of examined interventions, the evidence supporting the efficacy of most dietary factors appears inadequate to recommend their use.

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Section: Antioxidants and Psa Kineticsmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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“…Calcitriol binds intracellular vitamin D receptors (VDRs), which then heterodimerize with the retinoid X receptor (RXR) and co-activators. The complex then binds to promoter regions of vitamin D response elements, which modulate the expression of various genes for skeletal and nonskeletal homeostasis [3,4].…”

Section: Introductionmentioning

confidence: 99%

Cholecalciferol Inhibits Cell Growth and Induces Apoptosis in the CaSki Cell Line

et al. 2020

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Vitamin D has displayed anti-cancer actions in numerous in vitro studies. Here, we investigated the anti-cancer actions of cholecalciferol, a vitamin D precursor, on a metastatic cervical cancer cell line, namely, CaSki. Experimental cultures were incubated for 72 h and treated with cholecalciferol (10–1000 ng/mL). In the present study, cell count, viability, proliferation and cell cycle were analyzed by a crystal violet assay, trypan blue assay, Ki67 proliferation, and a cell cycle assay, respectively. Biomarkers of apoptosis, necrosis, and autophagic cell death were measured by the Caspase 3/7 and Annexin V/7-AAD Muse™ assays, a LC3-II assay, and a lactate dehydrogenase release assay, respectively. The ultrastructural features of cell death were assessed by transmission electron microscopy. A statistical analysis was performed using a one-way ANOVA and Bonferroni’s post-hoc analysis test, and p < 0.05 is considered statistically significant here. The results identify statistical decreases in cell count and viability at high-dose treatments (100 and 1000 ng/mL). In addition, significant increases in apoptotic biochemical markers and apoptotic ultrastructure are shown to be present at high-dose treatments. In conclusion, high-dose cholecalciferol treatments inhibit cell count and viability, which are both mediated by apoptotic induction in the CaSki cell line.

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“…Vitamin D is synthesized in the body through a complex series of steps beginning in the skin, under the influence of ultraviolet light, where a cholesterol precursor molecule (7-dehydrocholesterol) is transformed into the Vitamin D hormone precursor, cholecalciferol (also known as Vitamin D3). Vitamin D3 is subsequently hydroxylated in the liver by the 25-hydroxycholecalciferol and transformed in calcidiol or calcifediol (25(OH)D 3 or 25D 3 ), and this latter is subjected, in the kidney, to an hydroxylation, to yield the most active hormone form of these compounds, calcitriol (1,25-dihydroxycholecalciferol or 1,25(OH) 2 D 3 or 1,25D 3 ) [1]. The three main stages in Vitamin D metabolism, 25-hydroxylation, 1α-hydroxylation and 24-hydroxylation, are all performed by cytochrome P450 mixed-function oxidases (CYPs).…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Markers of Prostate Cancer Progression, Potentially Modulated by Vitamin D

et al. 2019

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Prostate cancer (PCa) is one of the most common cancers in men. The main risk factors associated with the disease include older age, family history of the disease, smoking, alcohol and race. Vitamin D is a pleiotropic hormone whose low levels are associated with several diseases and a risk of cancer. Here, we undertook microarray analysis in order to identify the genes involved in PCa. We analyzed three PCa microarray datasets, overlapped all genes significantly up-regulated, and subsequently intersected the common genes identified with the down-regulated genes transcriptome of LNCaP cells treated with 1α,25(OH)2D3, in order to identify the common genes involved in PCa and potentially modulated by Vitamin D. The analysis yielded 43 genes potentially involved in PCa and significantly modulated by Vitamin D. Noteworthy, our analysis showed that six genes (PRSS8, SOX4, SMYD2, MCCC2, CCNG2 and CD2AP) were significantly modulated. A Pearson correlation analysis showed that five genes out of six (SOX4 was independent), were statistically correlated with the gene expression levels of KLK3, and with the tumor percentage. From the outcome of our investigation, it is possible to conclude that the genes identified by our analysis are associated with the PCa and are potentially modulated by the Vitamin D.

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Vitamin D in prostate cancer

Cited by 76 publications

References 116 publications

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Cholecalciferol Inhibits Cell Growth and Induces Apoptosis in the CaSki Cell Line

Identification of Novel Markers of Prostate Cancer Progression, Potentially Modulated by Vitamin D

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