Vitamin D in Space

Khoshvaghti, Amir

doi:10.5772/intechopen.82314

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Due to the timely interaction of the doctors involved in the experiments and the research groups in charge, with the investigation of metabolic changes, the vitamin D deficiency in 10 volunteers was detected and subsequently corrected. The problem of the vitamin D deficiency is still acute onboard the International space station, for this substance affects many body processes, including the development of osteoporosis [25].…”

Section: Discussionmentioning

confidence: 99%

Medical Support for Space Missions: The Case of the SIRIUS Project

et al. 2023

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Medical support is one of the essential safety conditions for isolation or confinement experiments, as it enables the timely arrangement of actions to preserve the health of crew members and volunteers. Such analog experiments allow the testing of prospective medical technologies and methods for health support in long-term space missions and on-planet stations. In the current paper, we report the results of the medical control within the medical support system of the two model isolation experiments of the SIRIUS series, lasting for 4 and 8 months, respectively. The results indicate the prevalence of headache complaints, skin inflammatory reactions, and sleep disturbance during the longer confinement experiment. In addition, signs of vitamin D deficiency were revealed in 10 of the 12 objects. The data exchange with the scientific branch of the experiments provides for the in-time detection of early symptoms of disease, using samples of blood, urine, saliva, epithelia, etc. However, the issues of medical data confidence and, subsequently, of the crew members’ compliance with the medical staff, become pointed. In general, the work demonstrates the expediency of the investigations, including the data collection and analysis of the medical control indicators in further experiments, for the optimization of the medical support of both the analogous research projects and the development of the recommendations for the medical support of small autonomous groups, such as manned space missions.

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Section: Discussionmentioning

confidence: 99%

Medical Support for Space Missions: The Case of the SIRIUS Project

et al. 2023

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Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults?

Cannavò¹,

Carandina

Corbi

et al. 2022

Life

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Microgravity exposure causes several physiological and psychosocial alterations that challenge astronauts’ health during space flight. Notably, many of these changes are mostly related to physical inactivity influencing different functional systems and organ biology, in particular the musculoskeletal system, dramatically resulting in aging-like phenotypes, such as those occurring in older persons on Earth. In this sense, sarcopenia, a syndrome characterized by the loss in muscle mass and strength due to skeletal muscle unloading, is undoubtedly one of the most critical aging-like adverse effects of microgravity and a prevalent problem in the geriatric population, still awaiting effective countermeasures. Therefore, there is an urgent demand to identify clinically relevant biological markers and to underline molecular mechanisms behind these effects that are still poorly understood. From this perspective, a lesson from Geroscience may help tailor interventions to counteract the adverse effects of microgravity. For instance, decades of studies in the field have demonstrated that in the older people, the clinical picture of sarcopenia remarkably overlaps (from a clinical and biological point of view) with that of frailty, primarily when referred to the physical function domain. Based on this premise, here we provide a deeper understanding of the biological mechanisms of sarcopenia and frailty, which in aging are often considered together, and how these converge with those observed in astronauts after space flight.

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Vitamin D in Space

Cited by 2 publications

References 67 publications

Medical Support for Space Missions: The Case of the SIRIUS Project

Medical Support for Space Missions: The Case of the SIRIUS Project

Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults?

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