Vitamin D in systemic lupus erythematosus

Abstract

Multiple systemic lupus erythematosus cohorts have low vitamin D levels. The physiologic and clinical consequences of vitamin D deficiency in systemic lupus erythematosus are not entirely known. Prospective studies of vitamin D in systemic lupus erythematosus are limited, but most cross-sectional studies show an inverse relationship between levels of vitamin D and disease activity. This suggests that repletion of vitamin D may have benefits beyond bone health for patients with systemic lupus erythematosus.

Low bone mass in juvenile onset sclerosis systemic: the possible role for 25-hydroxyvitamin D insufficiency

“…Of interest, vitamin D has also immunomodulatory properties with a potential benefit for autoimmune disease [6]. In fact, a high prevalence of vitamin D deficiency has been reported in rheumatologic outpatients [7][8][9][10][11][12][13], including autoimmune diseases such as systemic lupus erythematosus [8][9][10][11][12] and arthritis rheumatoid [9,10,13,14]. Recently, high frequency of low levels of vitamin D and secondary hyperparathyroidism was described in Mediterranean SSc patients partially explained by traditional dress habits and low exposure to sun [15].…”

Vitamin D status and its modulatory effect on interferon gamma and interleukin-10 production by peripheral blood mononuclear cells in culture

“…Vitamin D deficiency has been linked to several autoimmune diseases including systemic lupus erythematosus [8], multiple sclerosis [9], rheumatoid arthritis [10], diabetes mellitus [11] and inflammatory bowel disease [12]. The prevalence of vitamin D deficiency in autoimmune diseases together with the antiinflammatory effect of vitamin D suggest the beneficial effect of vitamin D supplements in vitamin D deficient individuals with autoimmune diseases.…”

Relationship Between Serum 25 Hydroxy Vitamin D Levels and Disease Activity in Patients with Rheumatoid Arthritis

“…Kamen ve ark. [17] tarafından yapılan bir derlemede sistemik lupus eritematozus hastalarında düşük serum D vitamini düzeylerinin artmış hastalık aktivitesi ile ilişkisini gösteren çalışmalar bildirilmiştir. Başka bir inflamatuvar romatizmal hastalık olan Behçet hastalığında da serum D vitamini düzeyleri ile hastalık aktivitesi arasında negatif yönde anlamlı ilişki tespit edilmiştir [18] .…”