Vitamin D in the Parkinson Associated Risk Syndrome (PARS) study

Fullard, Michelle; Xie, Sharon X.; Marek, Kenneth; Stern, Matthew B.; Jennings, Danna; Siderowf, Andrew; Willis, Allison W.

doi:10.1002/mds.27127

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…A recent study by Fullard et al evaluated vitamin D levels in a population at risk for developing PD, derived from The Parkinson Associated Risk Syndrome (PARS) study cohort. In particular, they found that vitamin D levels did not differ in the high-risk group when compared with age- and sex-matched controls, suggesting that sustained vitamin D insufficiency is not common before a diagnosis of PD [ 142 ]. This is in line with another recent study of Larsson et al, which used Mendelian randomization approach to minimize confounding effects and prevent bias because of reverse causation.…”

Section: Parkinson’s Disease and Vitamin Dmentioning

confidence: 99%

Vitamin D and Neurological Diseases: An Endocrine View

Somma

Scarano

Barrea³

et al. 2017

IJMS

191

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Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the “non-calcemic” actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. In parallel, growing evidence has recognized that a multimodal association links vitamin D system to brain development, functions and diseases. With vitamin D deficiency reaching epidemic proportions worldwide, there is now concern that optimal levels of vitamin D in the bloodstream are also necessary to preserve the neurological development and protect the adult brain. The aim of this review is to highlight the relationship between vitamin D and neurological diseases.

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Section: Parkinson’s Disease and Vitamin Dmentioning

confidence: 99%

Vitamin D and Neurological Diseases: An Endocrine View

Somma

Scarano

Barrea³

et al. 2017

IJMS

191

View full text Add to dashboard Cite

show abstract

“…Accordingly, inadequate vitamin D status may play a significant role in PD, resulting in a progressive loss of DA neurons in the human brain [46]. However, experimental data from the Asymptomatic Parkinson Associated Vitamin D Intake Risk Syndrome cohort were not consistent with the hypothesis that chronically inadequate levels of vitamin D threaten the integrity of the DA system, leading to the pathogenesis of PD [47]. The conundrum of the connection between serum vitamin D levels and PD therefore remains unsolved.…”

Section: Introductionmentioning

confidence: 99%

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Tan

et al. 2020

Transl Neurodegener

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In recent years, many studies have investigated the correlations between Parkinson's disease (PD) and vitamin D status, but the conclusion remains elusive. The present review focuses on the associations between PD and serum vitamin D levels by reviewing studies on the associations of PD with serum vitamin D levels and vitamin D receptor (VDR) gene polymorphisms from PubMed, Web of Science, Cochrane Library, and Embase databases. We found that PD patients have lower vitamin D levels than healthy controls and that the vitamin D concentrations are negatively correlated with PD risk and severity. Furthermore, higher vitamin D concentrations are linked to better cognitive function and mood in PD patients. Findings on the relationship between VDR gene polymorphisms and the risk of PD are inconsistent, but the FokI (C/T) polymorphism is significantly linked with PD. The occurrence of FokI (C/T) gene polymorphism may influence the risk, severity, and cognitive ability of PD patients, while also possibly influencing the effect of Vitamin D 3 supplementation in PD patients. In view of the neuroprotective effects of vitamin D and the close association between vitamin D and dopaminergic neurotransmission, interventional prospective studies on vitamin D supplementation in PD patients should be conducted in the future.

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“…On the other hand, a study carried out by Fullard and colleagues [30] assessed the vitamin D serum level in a population at risk for developing PD. They did not find any statistically significant difference between the high-risk group and the age-and sex-matched control group, suggesting that vitamin D deficiency is not considered a risk for developing PD.…”

Section: Discussionmentioning

confidence: 99%

Could vitamin D deficiency have an impact on motor and cognitive function in Parkinson’s disease?

Soliman

Oraby

Hussein

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Background: Multiple epidemiological data showed a significant higher prevalence of hypovitaminosis D in patients with Parkinson's disease (PD). Objectives: To assess the serum vitamin D level in patients with Parkinson's disease and to investigate the possible relationship between the serum vitamin D level and both motor and cognitive symptoms in Parkinson's disease Materials and methods: A case-control study was conducted on 25 patients who fulfilled the criteria for diagnosis of idiopathic Parkinson's disease based on the British Brain Bank criteria, and 25 healthy volunteers. Selected PD patients were submitted for assessment of cognitive function using the PD-Cognitive Rating Scale (PD-CRS) and assessment of motor function using the Unified Parkinson's Disease Rating Scale (UPDRS). Serum 25 hydroxy vitamin D level was measured for all the included patients and controls. Results: PD patients were found to have a significantly lower level of serum vitamin D than controls (P value = 0.001). There was a statistically significant negative correlation between the serum vitamin D level and the scores of motor, mentation, activities of daily living, medication complication, other complications, and the total score of UPDRS (P value = 0.01, < 0.001, 0.012, 0.017, 0.039, and 0.002 respectively). There was a statistically significant positive correlation between the serum vitamin D level and the scores of attention, working memory, immediate recall, delayed recall, naming, visuoperceptual abilities, visuoconstructional abilities, alternating verbal fluency, action verbal fluency, and the total score of PD-CRS (P value < 0.001 in all parameters). Conclusion: Vitamin D deficiency is evident in PD patient, and such deficiency significantly affected both motor and cognitive symptoms.

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Vitamin D in the Parkinson Associated Risk Syndrome (PARS) study

Cited by 17 publications

References 18 publications

Vitamin D and Neurological Diseases: An Endocrine View

Vitamin D and Neurological Diseases: An Endocrine View

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Could vitamin D deficiency have an impact on motor and cognitive function in Parkinson’s disease?

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