Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation

Burjiah, Alfi; adi, Ashon; Widjiati, Widjiati

doi:10.5455/ovj.2022.v12.i6.23

Cited by 8 publications

(13 citation statements)

References 36 publications

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“…A total of 40 ICR mice (gender, female; age, 5 wk old; HFK Bio-Technology, Beijing, China) were randomly divided into the following four groups ( n = 10): the control group; the OHSS group; the OHSS + 16 IU VD3 group; and the OHSS + 24 IU VD3 group. To establish an OHSS mouse model, ovarian induction and VD3 administration were carried out as previously described by Jiang et al and Burjiah et al ( 2022 ) respectively. Mice in the control group were first subcutaneously injected with 10 IU pregnant mare serum gonadotrophin (PMSG).…”

Section: Methodsmentioning

confidence: 99%

Vitamin D3 reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3

Zhang,

Chen,

et al. 2024

In Vitro Cell.Dev.Biol.-Animal

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It has been reported that the effective inhibition of vascular endothelial growth factor (VEGF) can prevent the progression of ovarian hyperstimulation syndrome (OHSS). The present study aimed to investigate the mechanism underlying the effect of vitamin D3 (VD3) on OHSS in mouse models and granulosa cells. The effects of VD3 administration (16 and 24 IU) on ovarian permeability were determined using Evans blue. In addition, ovarian pathology, corpus luteum count, inflammatory responses, and hormone and VEGFA levels were assessed using pathological sections and ELISA. Molecular docking predicted that pentraxin 3 (PTX3) could be a potential target of VD3, and therefore, the effects of human chorionic gonadotropin (hCG) and VD3 as well as PTX3 overexpression on the production and secretion of VEGFA in granulosa cells were also investigated using western blotting and immunofluorescence. Twenty-four IU VD3 significantly reversed the increase in ovarian weight and permeability in mice with OHSS. Additionally, VD3 diminished congestion and the number of corpus luteum in the ovaries and reduced the secretion levels of inflammatory factors and those of estrogen and progesterone. Notably, VD3 downregulated VEGFA and CD31 in ovarian tissues, while the expression levels of PTX3 varied among different groups. Furthermore, VD3 restored the hCG-induced enhanced VEGFA and PTX3 expression levels in granulosa cells, whereas PTX3 overexpression abrogated the VD3-mediated inhibition of VEGFA production and secretion. The present study demonstrated that VD3 could inhibit the release of VEGFA through PTX3, thus supporting the beneficial effects of VD3 administration on ameliorating OHSS symptoms.

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Section: Methodsmentioning

confidence: 99%

Vitamin D3 reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3

Zhang,

Chen,

et al. 2024

In Vitro Cell.Dev.Biol.-Animal

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“…Consistent with this study, the finding of another study revealed regression of endometrial implants as a result of vitamin D treatment in a rat model of endometriosis [ 195 ]. Vitamin D was found to prevent the development of endometriosis in mice by controlling interleukin-17 levels [ 196 ].…”

Section: The Role Of Vitamin D In the Pathogenesis Of Endometriosismentioning

confidence: 99%

Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis

Farhangnia,

Noormohammadi,

Delbandi

2024

Reprod Health

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Vitamin D is a fat-soluble steroid hormone that was initially known only for regulating calcium and phosphorus levels and maintaining bone health. However, it was later discovered that many organs express vitamin D metabolizing enzymes and have a ligand for vitamin D, which regulates the expression of an extensive assortment of genes. As a result, vitamin D is indispensable for the proper function of organs, and its deficiency is believed to be a critical factor in symptoms and disorders such as cardiovascular diseases, autoimmune diseases, and cancers. The significance of vitamin D in reproductive tissues was recognized later, and studies have revealed its crucial role in male and female fertility, as well as proper reproductive function during pregnancy. Vitamin D deficiency has been identified as a risk factor for infertility, gonadal cancers, pregnancy complications, polycystic ovary syndrome, and endometriosis. However, data investigating the association between vitamin D levels and reproductive disorders, including endometriosis, have encountered inconsistencies. Therefore, the present study aims to review existing research on the effect of vitamin D on proper reproductive function, and the role of deficiency in reproductive diseases and specifically focuses on endometriosis.

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“…Several of the conducted animal studies found vitamin D to reduce the size or volume of endometriotic lesions [ 44 , 45 , 46 ].…”

Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

“…Furthermore, it has been noticed that vitamin D has the potential to interact with proinflammatory cytokines and other molecules intermediating in inflammatory processes. Thus, under the influence of vitamin D, the production of interleukin-17 (IL-17) [ 44 ] and IL-6 decreases [ 47 , 50 ]. Additionally, the experimental study conducted by Miyashita et al found that ectopic endometrial stromal cells (EESCs) incubated with 1,25-(OH) 2 D 3 were characterized with significantly lower amounts of IL-8, cyclooxygenase-2 (COX-2) mRNA, and prostaglandin E2 (PGE2) [ 48 ].…”

Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

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How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

Abramiuk,

Mertowska,

Frankowska

et al. 2024

Nutrients

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Endometriosis is a chronic, hormone-dependent disease characterized by the presence of endometrial tissue in ectopic locations. Since the treatment options for this disease are still limited, and the cure rate is unsatisfactory, the search for ways to treat symptoms and modify the course of the disease is of key importance in improving the quality of life of patients with endometriosis. So far, the literature has shown that nutrition can influence endometriosis through hormonal modification and altering the inflammatory or oxidative response. Since the importance of nutrition in this disease is still a subject of scientific research, we aimed to summarize the current knowledge on the role of dietary modifications in endometriosis. Our review showed that nutrients with anti-inflammatory and antioxidant properties, including most vitamins and several trace elements, may influence the pathogenesis of endometriosis and can be considered as the nutrients preventing the development of endometriosis. However, despite the many discoveries described in this review, further interdisciplinary research on this topic seems to be extremely important, as in the future, it may result in the development of personalized therapies supporting the treatment of endometriosis.

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Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation

Cited by 8 publications

References 36 publications

Vitamin D3 reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3

Vitamin D3 reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3

Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

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