Vitamin D insufficiency and cognitive impairment in Asians: a multi‐ethnic population‐based study and meta‐analysis

Abstract

Vitamin D insufficiency is associated with a greater likelihood of and more severe cognitive impairment in Asian populations.

Prevalence and Determinants of Suboptimal Vitamin D Levels in a Multiethnic Asian Population

“…There have also been data showing vitamin D deficiency to be associated with cardiovascular disease [7], cancer [7], diabetes [8], cognitive impairment [9], and all-cause mortality [10], although evidence for these non-skeletal conditions remain inconclusive [11]. These detrimental effects are not limited to persons with deficient vitamin D levels, as a systematic review found that merely having an insufficient 25(OH)D concentration (21–29 ng/mL [12]) predisposed women to breast cancer, and poorer survival rates in those diagnosed with lymphoma [13].…”

Effects of vitamin D3supplementation on cognition and blood lipids: a 12-month randomised, double-blind, placebo-controlled trial

“…Vitamin D can play an important role in brain health and function, and exert various neuroprotective effects in brain areas essential for cognition 6. Being severely deficient in vitamin D is associated with a more than twofold increased risk of developing dementia 7.…”

Relationship between cumulative ultraviolet exposure and cognitive function in a rural elderly Chinese population

“…Studies have found that vitamin D receptors are widespread in both neurons and glial cells. [3][4][5] Animal experiments based on mice have also demonstrated that vitamin D deficiency leads to mild cognitive impairment. 2 Therefore, vitamin D may be related to cognition.…”